Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Bernard, Leroy"'
Comprehensive assessment of TP53 loss of function using multiple combinatorial mutagenesis libraries
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract The diagnosis of somatic and germline TP53 mutations in human tumors or in individuals prone to various types of cancer has now reached the clinic. To increase the accuracy of the prediction of TP53 variant pathogenicity, we gathered functio
Externí odkaz:
https://doaj.org/article/0b0146cc59364ff9b0de255c6286014d
Autor:
Thierry Soussi, Pierre Hainaut, Peter E.M. Taschner, Joseph F. Fraumeni, Thorsten Zenz, Robert Zeillinger, Patricia N. Tonin, Louise C. Strong, Sharon A. Savage, Davide Rossi, Patricia Ashton-Prolla, Sarka Pospisilova, Kim E. Nichols, Jeffrey N. Myers, Ute M. Moll, David Malkin, Phuong L. Mai, Jacqueline Lehmann-Che, Richard Iggo, Eva Hellstrom-Lindberg, Anita Langerød, Gianluca Gaidano, Pierre Fenaux, Wafik S. El-Deiry, Lawrence A. Donehower, Nicole Concin, Antony Braithwaite, Gareth L. Bond, Fanny Baran-Marszak, Mandy L. Ballinger, Bernard Leroy
Accurate assessment of TP53 gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li–Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and therapy. Genomic data from m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287bd11319667648ab1c91bba0bb64f3
https://doi.org/10.1158/0008-5472.c.6509369
https://doi.org/10.1158/0008-5472.c.6509369
Autor:
Quentin Lenglet, Karine Lacroix, Tristan Pascart, Sahara Graf, Adeline Versavel, Roman Chiquet, Marie Moukagni, Guillaume Bouquet, Vincent Ducoulombier, Amelie Devaux, Alexandre Kone, Bernard Leroy, Eric Houvenagel, Stéphane Verdun, Gauthier Calais, Robert Jeanson, Antoine Lefebvre, Marie Ledein, Adeline Grimbert, Benoit Coviaux, Fabienne Martellier, Didier Duthoit
Publikováno v:
Pain Management Nursing. 21:572-578
Background Anxiety is common in hospitalized patients and can worsen pain or lead to unsuccessful pain relief. Aims The purpose of this study was to evaluate the usefulness of measuring anxiety with a visual analog scale (VAS) in the hospitalized pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99914973dd4485b89dbc9d961510b3d1
https://doi.org/10.1016/j.pmn.2020.03.004
https://doi.org/10.1016/j.pmn.2020.03.004
Publikováno v:
Briefings in Bioinformatics. 23
Correctly identifying the true driver mutations in a patient’s tumor is a major challenge in precision oncology. Most efforts address frequent mutations, leaving medium- and low-frequency variants mostly unaddressed. For TP53, this identification i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a669e74879a52044eb6872de545ba5
https://doi.org/10.1093/bib/bbab524
https://doi.org/10.1093/bib/bbab524
Autor:
Bernard, Leroy, Mandy L, Ballinger, Fanny, Baran-Marszak, Gareth L, Bond, Antony, Braithwaite, Nicole, Concin, Lawrence A, Donehower, Wafik S, El-Deiry, Pierre, Fenaux, Gianluca, Gaidano, Anita, Langerød, Eva, Hellstrom-Lindberg, Richard, Iggo, Jacqueline, Lehmann-Che, Phuong L, Mai, David, Malkin, Ute M, Moll, Jeffrey N, Myers, Kim E, Nichols, Sarka, Pospisilova, Patricia, Ashton-Prolla, Davide, Rossi, Sharon A, Savage, Louise C, Strong, Patricia N, Tonin, Robert, Zeillinger, Thorsten, Zenz, Joseph F, Fraumeni, Peter E M, Taschner, Pierre, Hainaut, Thierry, Soussi
Publikováno v:
Cancer Res
Accurate assessment of TP53 gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li-Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance and therapy. Genomic data from more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e12ed2d712fefd28caf178120e37195b
https://pubmed.ncbi.nlm.nih.gov/28254861
https://pubmed.ncbi.nlm.nih.gov/28254861
Autor:
Bernard-Leroy
Publikováno v:
Revue Philosophique de la France et de l'Étranger, 1910 Jan 01. 69, 65-69.
Externí odkaz:
https://www.jstor.org/stable/41080612
Autor:
Eleonóra Kiss, István E. Markó, Mélanie Marchant, Nuno Maulide, Christophe Hermans, Bernard Leroy, Guillaume Berthon-Gelloz, Nicolas Heureux, Sebastien Hermant, Pierre Wasnaire
Publikováno v:
Tetrahedron Letters. 46:79-83
The preparation of the novel trans-1,2-bis-stannylcyclopropane 4 is described. Its applications in Kosugi-Migita-Stille cross-coupling and in tin-lithium exchange reactions are presented and discussed. (C) 2004 Elsevier Ltd. All rights reserved.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bd85e3207749e7d2d8d330884289f8
https://doi.org/10.1016/j.tetlet.2004.11.036
https://doi.org/10.1016/j.tetlet.2004.11.036
Autor:
Jean-Paul Declercq, Christophe Dubost, Bernard Tinant, Bernard Leroy, Justin Bryans, István E. Markó
Publikováno v:
Tetrahedron. 60:7693-7704
Enantiomerically pure syn-anti and syn-syn configured triol units are efficiently synthesized by the SnCl4 mediated allylation of chiral alpha-benzyloxyaldehydes with the uniquely functionalised allylstannane 9. Remarkably, the stereochemistry of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40683b9698de15ae0bbbfec5be41ea0
https://doi.org/10.1016/j.tet.2004.06.084
https://doi.org/10.1016/j.tet.2004.06.084
Autor:
Bernard Leroy, István E. Markó, Arnaud Gautier, Ali Ates, Yannick Quesnel, Jean-Christophe Vanherck, Jean-Marc Plancher
Publikováno v:
Tetrahedron. 59:8989-8999
Cerium(IV) ammonium nitrate (CAN) is a powerful, though mild, reagent for the efficient and selective removal of a range of ketals and acetals. This novel deprotection method requires only catalytic amounts of CAN and tolerates a variety of functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f141342b6c8553c03d6d94b9e64c2f8
https://doi.org/10.1016/j.tet.2003.03.002
https://doi.org/10.1016/j.tet.2003.03.002
Autor:
Daniel J. Bayston, Raphael Dumeunier, István E. Markó, Jean-Marc Plancher, Cedric Leclercq, Abdelaziz Mekhalfia, Bernard Leroy
Publikováno v:
Synthesis. 2002:958-972
The ene-reaction between a variety of aldehydes and allylsilane 22 generates highly functionalised homoallylic alcohols 23. These adducts undergo a subsequent Intramolecular Sakurai Cyclisation (IMSC), affording in good yields polysubstituted tetrahy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b1d91149dce521ec6188de727db10f2
https://doi.org/10.1055/s-2002-28506
https://doi.org/10.1055/s-2002-28506