The angiotensin (1–7) glycopeptide PNA5 improves cognition in a chronic progressive mouse model of Parkinson's disease through modulation of neuroinflammation

Autor: Bernard, Kelsey, Mota, Jesus A., Wene, Paige, Corenblum, Mandi J., Saez, Juben L., Bartlett, Mitchell J., Heien, M. Leandro, Doyle, Kristian P., Polt, Robin, Hay, Meredith, Madhavan, Lalitha, Falk, Torsten

Publikováno v: In Experimental Neurology November 2024 381

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Design and Synthesis of Brain Penetrant Glycopeptide Analogues of PACAP With Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism.

Autor: Apostol CR; Department of Chemistry and Biochemistry, BIO5, The University of Arizona, Tucson, AZ, United States., Bernard K; Graduate Interdisciplinary Program in Physiological Sciences, The University of Arizona, Tucson, AZ, United States., Tanguturi P; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ, United States., Molnar G; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ, United States., Bartlett MJ; Department of Neurology, College of Medicine, The University of Arizona, Tucson, AZ, United States., Szabò L; Department of Chemistry and Biochemistry, BIO5, The University of Arizona, Tucson, AZ, United States., Liu C; Department of Chemistry and Biochemistry, BIO5, The University of Arizona, Tucson, AZ, United States., Ortiz JB; Barrow Neurological Institute at Phoenix Children's Hospital, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States.; Phoenix Veteran Affairs Health Care System, Phoenix, AZ, United States., Saber M; Barrow Neurological Institute at Phoenix Children's Hospital, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States., Giordano KR; Barrow Neurological Institute at Phoenix Children's Hospital, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States.; Phoenix Veteran Affairs Health Care System, Phoenix, AZ, United States., Green TRF; Department of Child Health, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States., Melvin J; Department of Child Health, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States.; Department of Biological Sciences, University of Bath, Bath, United Kingdom., Morrison HW; College of Nursing, University of Arizona, Tucson, AZ, United States., Madhavan L; Graduate Interdisciplinary Program in Physiological Sciences, The University of Arizona, Tucson, AZ, United States.; Department of Neurology, College of Medicine, The University of Arizona, Tucson, AZ, United States., Rowe RK; Barrow Neurological Institute at Phoenix Children's Hospital, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States.; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States., Streicher JM; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ, United States., Heien ML; Department of Chemistry and Biochemistry, BIO5, The University of Arizona, Tucson, AZ, United States., Falk T; Graduate Interdisciplinary Program in Physiological Sciences, The University of Arizona, Tucson, AZ, United States.; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ, United States.; Department of Neurology, College of Medicine, The University of Arizona, Tucson, AZ, United States., Polt R; Department of Chemistry and Biochemistry, BIO5, The University of Arizona, Tucson, AZ, United States.

Publikováno v: Frontiers in drug discovery [Front Drug Discov (Lausanne)] 2022 Jan; Vol. 1. Date of Electronic Publication: 2022 Jan 14.