Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Bernard, Kaptein"'
Autor:
Sjoerd W. van Dongen, Iaroslav Baglai, Michel Leeman, Richard M. Kellogg, Bernard Kaptein, Willem L. Noorduin
Publikováno v:
Chemical Communications. 59:3838-3841
Using a Soxhlet-apparatus, we demonstrate that a conglomerate-forming clopidogrel precursor undergoing solution phase racemization can be deracemized through cyclic solvent removal and re-addition.
Autor:
Sjoerd W. van Dongen, Imane Ahlal, Michel Leeman, Bernard Kaptein, Richard M. Kellogg, Iaroslav Baglai, Willem L. Noorduin
Publikováno v:
Journal of the American Chemical Society.
Amplification of enantiomeric excesses (ee) is routinely observed during chiral crystallization of conglomerate crystals for which the enantiomers undergo racemization in solution. Although routes comprising a combination of crystal growth and dissol
Autor:
Richard M. Kellogg, Sjoerd W. van Dongen, Iaroslav Baglai, Willem L. Noorduin, Bernard Kaptein, Michel Leeman
Publikováno v:
Israel journal of chemistry, 61(9-10), 645-649. Wiley-Blackwell
All biological systems are composed of molecules of a single chirality. Although many different scenarios can lead to chiral symmetry breaking, the transmission of the absolute configuration of one compound to another one remains challenging. We here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a63417acab4043f4a042207195484eb
https://dare.uva.nl/personal/pure/en/publications/counteracting-enantiospecific-behavior-of-tailormade-additives-during-chiral-symmetry-breaking-growth-inhibition-versus-solidsolution-formation(645e18d7-e7e0-4c12-a2cb-62a995654987).html
https://dare.uva.nl/personal/pure/en/publications/counteracting-enantiospecific-behavior-of-tailormade-additives-during-chiral-symmetry-breaking-growth-inhibition-versus-solidsolution-formation(645e18d7-e7e0-4c12-a2cb-62a995654987).html
Autor:
Michel Leeman, Iaroslav Baglai, Joop H. ter Horst, Willem L. Noorduin, Giulio Valenti, Bernard Kaptein, Richard M. Kellogg, Paul Tinnemans
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie, International Edition, 60(10), 5279-5282. John Wiley and Sons Ltd
Angewandte Chemie. International Edition, 60, 5279-5282
Angewandte Chemie. International Edition, 60, 10, pp. 5279-5282
Angewandte Chemie, 133(10), 5339-5342. John Wiley and Sons Ltd
Angewandte Chemie, International Edition, 60(10), 5279-5282. John Wiley and Sons Ltd
Angewandte Chemie. International Edition, 60, 5279-5282
Angewandte Chemie. International Edition, 60, 10, pp. 5279-5282
Angewandte Chemie, 133(10), 5339-5342. John Wiley and Sons Ltd
An efficient deracemization method for conversion of the racemate to the desirable (R)-enantiomer of Praziquantel has been developed by coupling incompatible racemization and crystallization processes. By a library approach, a derivative that crystal
Publikováno v:
Chemical communications (Cambridge, England). 55(48)
Herein we introduce a “chiral switch” – a sequence of operations that alternate between equilibrium and non-equilibrium conditions to switch the absolute configuration of a chiral center. The generality and practical potential of the technique
Autor:
Hans E. Schoemaker, Wilhelmus H.J. Boesten, Quirinus B. Broxterman, Eric C. Roos, Bernard Kaptein, Will J.J. van den Tweel, Johan Kamphuis, Emmo M. Meijer, Floris P.J.T. Rutjes
Publikováno v:
CHIMIA, Vol 51, Iss 6 (1997)
Aminopeptidase- and amidase-based methods for the production of enantiomerically pure amino acids, intermediates for pharmaceuticals and agrochemicals, are discussed. Furthermore, enzymatic syntheses of the dipeptide sweetener aspartame and semisynth
Externí odkaz:
https://doaj.org/article/c682ce31a4784b23a95dda9ab6badbe1
Publikováno v:
Chemical Communications, 52, 81, pp. 12048-12051
Chemical Communications, 52, 12048-12051
Chemical Communications, 52, 12048-12051
Viedma ripening allows the conversion of a solid state racemate into a single enantiomer. Using the gradual conversion of a metastable racemic compound into the conglomerate, the speed of deracemization for two amino acid derivatives could be conside
Autor:
Rakeshwar Bandichhor, Apurba Bhattacharya, Andrew Cosbie, Louis Diorazio, Peter Dunn, Kenneth Fraunhoffer, Fabrice Gallou, John Hayler, Matthew Hickey, Bill Hinkley, Luke Humphreys, Bernard Kaptein, Lynette Oh, Paul Richardson, Scott Roberts, Timothy White, Stijn Wuyts, Jingjun Yin
Publikováno v:
Organic Process Research & Development. 19:1924-1935
Autor:
Willem L. Noorduin, Iaroslav Baglai, Klaus Wurst, Bernard Kaptein, Richard M. Kellogg, Michel Leeman
Publikováno v:
Chemical communications (Cambridge, England). 54(77)
The Strecker reaction is broadly used for the preparation of α-amino acids. However, control of enantioselectivity remains challenging. We here couple the Strecker reaction to Viedma ripening for the absolute asymmetric synthesis of highly stericall
Autor:
Suju Mathew, Matthew R. Hickey, Lynnette Oh, Luke D. Humphreys, Paul G. Richardson, David Hughes, Peter J. Dunn, Timothy D. White, John D. Hayler, Stijn Wuyts, Bernard Kaptein, Fabrice Gallou, Bill Hinkley, Apurba Bhattacharya, Kenneth J. Fraunhoffer, Rakeshwar Bandichhor, Louis J. Diorazio
Publikováno v:
Organic Process Research & Development. 18:863-874