Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Bernard, Hanseeuw"'
Autor:
Emilien Boyer, Louise Deltenre, Marion Dourte, Lise Colmant, Esther Paître, Kristel Sleegers, Nuria Suelves, Bernard Hanseeuw, Pascal Kienlen-Campard
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Amyloid-β (Aβ) and tau are brain hallmarks of Alzheimer’s disease (AD), also present in blood as soluble biomarkers or encapsulated in extracellular vesicles (EVs). Our goal was to assess how soluble plasma biomarkers of AD pa
Externí odkaz:
https://doaj.org/article/e06a306f8fb548a7be1621092c910e71
Autor:
Mandy M.J. Wittens, Stijn Denissen, Diana M. Sima, Erik Fransen, Ellis Niemantsverdriet, Christine Bastin, Florence Benoit, Bruno Bergmans, Jean-Christophe Bier, Peter Paul de Deyn, Olivier Deryck, Bernard Hanseeuw, Adrian Ivanoiu, Gaëtane Picard, Annemie Ribbens, Eric Salmon, Kurt Segers, Anne Sieben, Hanne Struyfs, Evert Thiery, Jos Tournoy, Anne-Marie van Binst, Jan Versijpt, Dirk Smeets, Maria Bjerke, Guy Nagels, Sebastiaan Engelborghs
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Objectives This study aimed to evaluate the potential clinical value of a new brain age prediction model as a single interpretable variable representing the condition of our brain. Among many clinical use cases, brain age could be a novel ou
Externí odkaz:
https://doaj.org/article/31dd8603773e4eab883fb41094f7a697
Autor:
Zsolt Huszár, Marie Anne Engh, Márk Pavlekovics, Tomoya Sato, Yalea Steenkamp, Bernard Hanseeuw, Tamás Terebessy, Zsolt Molnár, Péter Hegyi, Gábor Csukly
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Measurement of beta-amyloid (Aβ) and phosphorylated tau (p-tau) levels offers the potential for early detection of neurocognitive impairment. Still, the probability of developing a clinical syndrome in the presence of these prote
Externí odkaz:
https://doaj.org/article/8ca4a5e5f360465b9d26946c659a4ae9
Autor:
Ilse Bader, Ilona Bader, Isadora Lopes Alves, David Vállez García, Bruno Vellas, Bruno Dubois, Mercè Boada, Marta Marquié, Daniele Altomare, Philip Scheltens, Rik Vandenberghe, Bernard Hanseeuw, Michael Schöll, Giovanni B. Frisoni, Frank Jessen, Agneta Nordberg, Miia Kivipelto, Craig W. Ritchie, Oriol Grau-Rivera, José Luis Molinuevo, Lisa Ford, Andrew Stephens, Rossella Gismondi, Juan Domingo Gispert, Gill Farrar, Frederik Barkhof, Pieter Jelle Visser, Lyduine E. Collij, on behalf of the AMYPAD consortium
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background The mismatch between the limited availability versus the high demand of participants who are in the pre-dementia phase of Alzheimer’s disease (AD) is a bottleneck for clinical studies in AD. Nevertheless, potential enrollment ba
Externí odkaz:
https://doaj.org/article/53ca117657b04d869c1e2fc37d173899
Autor:
Geoffroy Gagliardi, Elena Rodriguez-Vieitez, Victor Montal, Jorge Sepulcre, Ibai Diez, Cristina Lois, Bernard Hanseeuw, Aaron P. Schultz, Michael J. Properzi, Kathryn V. Papp, Gad A. Marshall, Juan Fortea, Keith A. Johnson, Reisa A. Sperling, Patrizia Vannini
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-10 (2023)
Abstract Introduction Non-invasive diffusion-weighted imaging (DWI) to assess brain microstructural changes via cortical mean diffusivity (cMD) has been shown to be cross-sectionally associated with tau in cognitively normal older adults, suggesting
Externí odkaz:
https://doaj.org/article/2f92c1fc8cc3460e9460c06eaf041613
Autor:
Mélina Régy, Aline Dugravot, Séverine Sabia, Elodie Bouaziz-Amar, Claire Paquet, Bernard Hanseeuw, Archana Singh-Manoux, Julien Dumurgier
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-11 (2023)
Abstract Background Alzheimer’s disease (AD) is the 5th leading cause of death in people 65 years and older. The ATN classification reflects a biological definition of AD pathology with markers of Aβ deposition (A), pathologic tau (T), and neurode
Externí odkaz:
https://doaj.org/article/7aa860f4a1e64498a732358a004133dc
Autor:
Lyduine E. Collij, Gill Farrar, David Valléz García, Ilona Bader, Mahnaz Shekari, Luigi Lorenzini, Hugh Pemberton, Daniele Altomare, Sandra Pla, Mery Loor, Pawel Markiewicz, Maqsood Yaqub, Christopher Buckley, Giovanni B. Frisoni, Agneta Nordberg, Pierre Payoux, Andrew Stephens, Rossella Gismondi, Pieter Jelle Visser, Lisa Ford, Mark Schmidt, Cindy Birck, Jean Georges, Anja Mett, Zuzana Walker, Mercé Boada, Alexander Drzezga, Rik Vandenberghe, Bernard Hanseeuw, Frank Jessen, Michael Schöll, Craig Ritchie, Isadora Lopes Alves, Juan Domingo Gispert, Frederik Barkhof
Publikováno v:
Frontiers in Neurology, Vol 13 (2023)
BackgroundAmyloid-β (Aβ) accumulation is considered the earliest pathological change in Alzheimer's disease (AD). The Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD) consortium is a collaborative European framework across European Federatio
Externí odkaz:
https://doaj.org/article/e7fa1233238f47be9c405a3b15ff6cf3
Autor:
Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi, Ilse Dewachter
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-21 (2021)
Abstract Alzheimer's disease (AD) is characterized by a sequential progression of amyloid plaques (A), neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While microglia are considered key contributors to AD pathogenes
Externí odkaz:
https://doaj.org/article/852fe2a6f7d24a1d8306a8d889edd584
Autor:
Geoffroy Gagliardi, Madeline Kuppe, Cristina Lois, Bernard Hanseeuw, Patrizia Vannini, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract Introduction Impaired self-awareness of memory function, a.k.a. anosognosia, is a common symptom in Alzheimer’s disease (AD); however, its pathological correlates remain unclear. Here, we investigated the impact of amyloid and tau on memor
Externí odkaz:
https://doaj.org/article/ef6b376dd87d41fca42bab9e594fadc3
Autor:
Mélina Régy, Aline Dugravot, Séverine Sabia, Aurore Fayosse, Jean-Francois Mangin, Marie Chupin, Clara Fischer, Vincent Bouteloup, Carole Dufouil, Geneviève Chêne, Claire Paquet, Bernard Hanseeuw, Archana Singh-Manoux, Julien Dumurgier
Publikováno v:
NeuroImage, Vol 250, Iss , Pp 118966- (2022)
Data on 2,045 non-demented individuals with memory complaints were drawn from the Memento cohort study to examine the association between Apolipoprotein E ε4 allele (APOE4) and regional brain gray matter volumes. Linear regression was used to examin
Externí odkaz:
https://doaj.org/article/0a49044bae604158840d746e5e6d9153