The Mitochondrial Import Complex MIM Functions as Main Translocase for α-Helical Outer Membrane Proteins

Autor: Kim Nguyen Doan, Alexander Grevel, Christoph U. Mårtensson, Lars Ellenrieder, Nicolas Thornton, Lena-Sophie Wenz, Łukasz Opaliński, Bernard Guiard, Nikolaus Pfanner, Thomas Becker

Publikováno v: Cell Reports, Vol 31, Iss 4, Pp - (2020)

Summary: The mitochondrial outer membrane contains integral proteins with α-helical membrane anchors or a transmembrane β-barrel. The translocase of the outer membrane (TOM) cooperates with the sorting and assembly machinery (SAM) in the import of

Externí odkaz: https://doaj.org/article/372cd7f158e048d6b4e2bc4a61552a3a

Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

Autor: Alexander Benjamin Schendzielorz, Piotr Bragoszewski, Nataliia Naumenko, Ridhima Gomkale, Christian Schulz, Bernard Guiard, Agnieszka Chacinska, Peter Rehling

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane. Here authors show that the import motor J-protein Pam18 controls lateral protei

Externí odkaz: https://doaj.org/article/5579f2342b364cb2902c5d7d5fcf3a26

Role of the small protein Mco6 in the mitochondrial sorting and assembly machinery

Autor: Jon V. Busto, Hannah Mathar, Conny Steiert, Eva F. Schneider, Sebastian P. Straub, Lars Ellenrieder, Jiyao Song, Sebastian B. Stiller, Philipp Lübbert, Bernard Guiard, Fabian den Brave, Uwe Schulte, Bernd Fakler, Thomas Becker, Nils Wiedemann

SUMMARYThe majority of mitochondrial precursor proteins are imported through the Tom40 β-barrel channel of the translocase of the outer membrane (TOM). The sorting and assembly machinery (SAM) is essential for β-barrel membrane protein insertion in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69a2ae70e0b950c1bbab7cca212dee99
https://doi.org/10.1101/2023.02.03.527057

Functional study of the Hap4-like genes suggests that the key regulators of carbon metabolism HAP4 and oxidative stress response YAP1 in yeast diverged from a common ancestor.

Autor: Nataliya Petryk, You-Fang Zhou, Kateryna Sybirna, Marie-Hélène Mucchielli, Bernard Guiard, Wei-Guo Bao, Oleh V Stasyk, Olena G Stasyk, Olena S Krasovska, Karine Budin, Nancie Reymond, Sandrine Imbeaud, Sophie Coudouel, Hervé Delacroix, Andriy Sibirny, Monique Bolotin-Fukuhara

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e112263 (2014)

The transcriptional regulator HAP4, induced by respiratory substrates, is involved in the balance between fermentation and respiration in S. cerevisiae. We identified putative orthologues of the Hap4 protein in all ascomycetes, based only on a conser

Externí odkaz: https://doaj.org/article/45b2907153a54bd8ac3c68fdc058afcd

Transmembrane Coordination of Preprotein Recognition and Motor Coupling by the Mitochondrial Presequence Receptor Tim50

Autor: Raffaele Ieva, Martin van der Laan, Bernard Guiard, Anne Caumont-Sarcos, Cyril Moulin, Lucyle Poinot

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2020, 30, pp.3092-3104.e4. ⟨10.1016/j.celrep.2020.02.031⟩
Cell Reports, Vol 30, Iss 9, Pp 3092-3104.e4 (2020)

Summary: Mitochondrial preproteins contain amino-terminal presequences directing them to the presequence translocase of the mitochondrial inner membrane (TIM23 complex). Depending on additional downstream import signals, TIM23 either inserts preprote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824353e5cc982728908a8fd3b6047660
https://pubmed.ncbi.nlm.nih.gov/32130909