Výsledky vyhledávání - "Bernard, Geudelin"

Mortality and adverse events with brand and generic clopidogrel in the US Food and Drug Administration Adverse Event Reporting System

Autor: Bernard Geudelin, Thomas A. Marciniak, Nikita Lomakin, Trygve S. Hall, Moo Hyun Kim, Stefan Agewall, Dan Atar, Victor L. Serebruany

Publikováno v: European heart journal. Cardiovascular pharmacotherapy. 5(4)

Aims Clopidogrel is commonly used even after expiring patents. The brand clopidogrel (BC) was dealt by single company, while numerous manufacturers produce generic clopidogrel (GC). There are no convincing data to compare the safety of different form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa99b37c05884df9e99a2c800216595f
https://pubmed.ncbi.nlm.nih.gov/30192939

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Aganirsen Antisense Oligonucleotide Eye Drops Inhibit Keratitis-Induced Corneal Neovascularization and Reduce Need for Transplantation

Publikováno v: Ophthalmology. 121(9):1683-1692

Objective Eye drops of aganirsen, an antisense oligonucleotide preventing insulin receptor substrate-1 expression, inhibited corneal neovascularization in a previous dose-finding phase II study. We aimed to confirm these results in a phase III study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920620f1aa12f576a85ca343ddac7023

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GS-101 Antisense Oligonucleotide Eye Drops Inhibit Corneal Neovascularization

Autor: Vincent Borderie, Klaus-Peter Steuhl, Felix Bock, Friedrich E. Kruse, Beatrice Früh, Berthold Seitz, Folkert K. Horn, Michael A. Thiel, Bernard Geudelin, Frank Wilhelm, Daniel Meller, Claus Cursiefen, Angela Hahn, Isabelle Descohand

Publikováno v: Ophthalmology. 116:1630-1637

Purpose Pathologic corneal neovascularization not only reduces corneal transparency and visual acuity, but also is one of the most significant preoperative and postoperative risk factors for graft rejection after corneal transplantation. The aim of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::700451877745208cd56233d2898d1925
https://doi.org/10.1016/j.ophtha.2009.04.016

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Tolerability and safety of GS-101 eye drops, an antisense oligonucleotide to insulin receptor substrate-1: a ‘first in man’ Phase I investigation

Autor: Eric Thorin, Bernard Geudelin, David Goldblum, Hermann Kain, Christoph Beglinger

Publikováno v: British Journal of Clinical Pharmacology

AIMS: GS-101 (GeneSignal, Epalinges, Switzerland) is an antisense oligonucleotide that inhibits the expression of the scaffold protein insulin receptor substrate-1 (IRS-1). Inhibition of IRS-1 results in the prevention of neovascular growth and was s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265aa2c134d8ccae2ab7608c01804e85
https://doi.org/10.1111/j.1365-2125.2009.03450.x

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Effect of Intravenous FX06 as an Adjunct to Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction

Autor: Peter Buser, Peter Riis Hansen, Tim Süselbeck, Marcos Marin-Galiano, Jiirg Schwitter, Bernard Geudelin, Christian Butter, Lars Grip, Peter Clemmensen, Peter Petzelbauer, Kurt Huber, Jarosław D. Kasprzak, Benno J. Rensing, Dan Atar

Publikováno v: Journal of the American College of Cardiology. 53:720-729

OBJECTIVES: The purpose of this study was to investigate whether FX06 would limit infarct size when given as an adjunct to percutaneous coronary intervention. BACKGROUND: FX06, a naturally occurring peptide derived from human fibrin, has been shown t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf3416ac1d4c13ac67b79d05641d7a1
https://doi.org/10.1016/j.jacc.2008.12.017

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Rationale and Design of the ‘F.I.R.E.’ Study

Autor: Rainer Henning, Carmen Theek, Kurt Huber, Stephen L. Kopecky, Jürg Schwitter, Bernard Geudelin, Dan Atar, Katherine Brandl, Hans-Jürgen Rupprecht

Publikováno v: Cardiology. 108:117-123

Immediate reopening of acutely occluded coronary arteries via primary percutaneous coronary intervention (PCI) is the treatment of choice to salvage the ischemic myocardium in the setting of ST-segment elevation myocardial infarction (STEMI). However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44aa970ec23a635db9dca3d292161756
https://doi.org/10.1159/000095982

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Impact of time to therapy and presence of collaterals on the efficacy of FX06 in acute ST elevation myocardial infarction: a substudy of the F.I.R.E., the Efficacy of FX06 in the prevention of myocardial reperfusion injury trial

Autor: Jürg Schwitter, Bernard Geudelin, Peter Petzelbauer, Peter Buser, Jonas Hallén, Dan Atar

Publikováno v: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 5(8)

To determine whether the efficacy of FX06 was dependent upon the timing of reperfusion therapy or the presence of collaterals in the Efficacy of FX06 in the prevention of myocardial reperfusion injury (F.I.R.E.) trial.Two hundred and thirty-four (234

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f165a3535da33c623d65d9d7bcb3c916
https://pubmed.ncbi.nlm.nih.gov/20542780

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Relation of cardiac troponin I measurements at 24 and 48 hours to magnetic resonance-determined infarct size in patients with ST-elevation myocardial infarction

Autor: Morten W. Fagerland, Dan Atar, Peter Buser, Allan S. Jaffe, Bernard Geudelin, Peter Petzelbauer, Jürg Schwitter, Jonas Hallén

Publikováno v: The American journal of cardiology. 104(11)

Levels of circulating cardiac troponin I (cTnI) or T are correlated to extent of myocardial destruction after an acute myocardial infarction. Few studies analyzing this relation have employed a second-generation cTnI assay or cardiac magnetic resonan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddb06ba5741cf322b387a0a4d10757f
https://pubmed.ncbi.nlm.nih.gov/19932777

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