Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke

Autor: Duricki, DA, Hutson, TH, Kathe, C, Soleman, S, Gonzalez-Carter, D, Petruska, JC, Shine, HD, Chen, Q, Wood, TC, Bernanos, M, Cash, D, Williams, SCR, Gage, FH, Moon, LDF

Publikováno v: Duricki, D A, Hutson, T H, Kathe, C, Soleman, S, Gonzalez-Carter, D, Petruska, J C, Shine, H D, Chen, Q, Wood, T C, Bernanos, M, Cash, D, Williams, S C R, Gage, F H & Moon, L D F 2016, ' Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke ', Brain : a journal of neurology, vol. 139, no. 1, pp. 259-275 . https://doi.org/10.1093/brain/awv341

There is an urgent need for a therapy that reverses disability after stroke when initiated in a time frame suitable for the majority of new victims. We show here that intramuscular delivery of neurotrophin-3 (NT3, encoded by NTF3) can induce sensorim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::652277a9d2dce7778a6445f24f1c721f
https://kclpure.kcl.ac.uk/ws/files/54781158/259.full.pdf

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Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT1A agonist in rat models of ischaemic stroke

Autor: Modo Michel M, McCreary Andrew, Bernanos Michel, Lowe Andrew S, Beech John S, Ashioti Maria, Williams Steve CR

Publikováno v: BMC Neuroscience, Vol 10, Iss 1, p 82 (2009)

Abstract Background 5HT1A agonists have previously been shown to promote recovery in animal models of stroke using ex vivo outcome measures which have raised the hopes for a potential clinical implementation. The purpose of this study was to evaluate

Externí odkaz: https://doaj.org/article/6d08c5db430548fc83e46e868efa5b91

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