Osteoporosis and ageing affects the migration of stem cells and this is ameliorated by transfection with CXCR4

Autor: Anita Sanghani-Kerai, P. Kalia, L. Di Silvio, Gordon Blunn, Melanie J. Coathup, S. Samazideh, Bernadine Idowu

Publikováno v: Bone & Joint Research
Sanghani-Kerai, A, Coathup, M, Samazideh, S, Kalia, P, Silvio, L D, Idowu, B & Blunn, G W 2017, ' Osteoporosis and ageing affects the migration of stem cells and this is ameliorated by transfection with CXCR4 ', Bone & Joint Research, vol. 6, no. 6, pp. 358-365 . https://doi.org/10.1302/2046-3758.66.BJR-2016-0259.R1

Objectives Cellular movement and relocalisation are important for many physiologic properties. Local mesenchymal stem cells (MSCs) from injured tissues and circulating MSCs aid in fracture healing. Cytokines and chemokines such as Stromal cell-derive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6106b4d636bb0a0f044c342a7ac7a9de
http://europepmc.org/articles/PMC5492335

Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway

Autor: null Presneau, Stephen R. Cannon, Adrienne M. Flanagan, Panagiotis D. Gikas, Roberto Tirabosco, Ivan Gout, Asem Shalaby, Timothy C. Diss, Bernadine Idowu

Publikováno v: British Journal of Cancer

Chordomas are radio- and chemo-resistant tumours and metastasise in as many as 40% of patients. The aim of this study was to identify potential molecular targets for the treatment of chordoma. In view of the reported association of chordoma and tuber

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac86c79cb1dbecbae2af9bb235c4c8ce
https://doi.org/10.1038/sj.bjc.6605019

Neurofibromatosis presenting with a cherubism phenotype

Autor: B. G. F. Heggelman, C. J. M. van der Sijs-Bos, P. J. Slootweg, C. I. van Capelle, P. H. G. Hogeman, Bernadine Idowu, A. R. M. Wittkampf, Adrienne M. Flanagan

Publikováno v: European Journal of Pediatrics, 166, 905-9
European Journal of Pediatrics, 166, 9, pp. 905-9

Item does not contain fulltext We report on a child who presented clinical manifestations of both neurofibromatosis type 1 (NF1) and cherubism. With genetic testing, we found a mutation in the NF-1 gene, confirming the neurocutaneous disorder. Histol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1b475188f91da8f12bc4bc3a606af3
https://doi.org/10.1007/s00431-006-0334-6

In vitro osteoinductive potential of porous monetite for bone tissue engineering

Autor: Lucy Di Silvio, Bernadine Idowu, Sanjukta Deb, Giuseppe Cama

Publikováno v: Journal of Tissue Engineering
Journal of Tissue Engineering, Vol 5 (2014)

Tissue engineering–based bone grafts are emerging as a viable alternative treatment modality to repair and regenerate tissues damaged as a result of disease or injury. The choice of the biomaterial component is a critical determinant of the success

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a1537e7537cedba69f4006e890464a
https://pubmed.ncbi.nlm.nih.gov/24904727

[Untitled]

Autor: Martin M. Knight, David A. Lee, Dan L. Bader, Bernadine Idowu

Publikováno v: Histochemical Journal. 32:165-174

This study reports the cytoskeletal organisation within chondrocytes, isolated from the superficial and deep zones of articular cartilage and seeded into agarose constructs. At day 0, marked organisation of actin microfilaments was not observed in ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a3b6a3e390e733008571e31c7d096ef
https://doi.org/10.1023/a:1004095207330