Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Bernadine G. C. Lu"'
Autor:
Xinyu Wu, Margareta Go, Julie V. Nguyen, Nathan W. Kuchel, Bernadine G. C. Lu, Kathleen Zeglinski, Kym N. Lowes, Dale J. Calleja, Jeffrey P. Mitchell, Guillaume Lessene, David Komander, Matthew E. Call, Melissa J. Call
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Papain-like protease (PLpro) is an attractive drug target for SARS-CoV-2 because it is essential for viral replication, cleaving viral poly-proteins pp1a and pp1ab, and has de-ubiquitylation and de-ISGylation activities, affecting innate imm
Externí odkaz:
https://doaj.org/article/f2aa5295a8ff4f9095605b082b38d19a
Autor:
Dale J. Calleja, Nathan Kuchel, Bernadine G. C. Lu, Richard W. Birkinshaw, Theresa Klemm, Marcel Doerflinger, James P. Cooney, Liana Mackiewicz, Amanda E. Au, Yu Q. Yap, Timothy R Blackmore, Kasiram Katneni, Elly Crighton, Janet Newman, Kate E. Jarman, Melissa J. Call, Bernhard C. Lechtenberg, Peter E. Czabotar, Marc Pellegrini, Susan A. Charman, Kym N. Lowes, Jeffrey P. Mitchell, Ueli Nachbur, Guillaume Lessene, David Komander
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalization and death of patients infected with SARS-CoV-2. The papain-like protease (PLpro) domain is part of the SARS-CoV-2 non
Externí odkaz:
https://doaj.org/article/78066ca793204c13adcbf61221072dfc
Publikováno v:
Methods in enzymology. 501
The serpin molecule has evolved an unusual mechanism of inhibition, involving an exposed reactive center loop (RCL) and conformational change to covalently trap a target protease. Successful inhibition of the protease is dependent on the rate of serp