Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Bernadette Marie McArdle"'
Autor:
Gordon J. King, Bernadette Marie McArdle, Stewart L. Fisher, Ronald J. Quinn, Leanne Towerzey, Priscila de Almeida Leone, John N. A. Hooper, Gunther Kern, Anthony R. Carroll
Publikováno v:
Organic Letters. 10:2585-2588
Bioassay-guided fractionation of the methanol extract of the Australian sponge Neopetrosia exigua led to the isolation of exiguaquinol (2), a new pentacyclic hydroquinone that inhibited Helicobacter pylori glutamate racemase (MurI) with an IC(50) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298fb7101e49ea56f64a1ed547ecd513
https://doi.org/10.1021/ol800898z
https://doi.org/10.1021/ol800898z
Autor:
Sandra Duffy, Ronald J. Quinn, Terese Alnefelt, Desley Jane Pitcher, Jennifer Mitchell, Vicky M. Avery, Bernadette Marie McArdle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6521-6524
Fourteen natural products, known to inhibit other proteins of the Zincin-like fold class, were screened for inhibition of the Zincin-like fold metalloprotease thermolysin using mass spectrometry. Fourier Transform Mass Spectrometry was successful in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d90566de4fa4e08ab70ea44c43022c
https://doi.org/10.1016/j.bmcl.2007.09.084
https://doi.org/10.1016/j.bmcl.2007.09.084
Identification of Protein Fold Topology Shared between Different Folds Inhibited by Natural Products
Publikováno v:
ChemBioChem. 8:788-798
Natural products have withstood the test of time as therapeutics, but new lead-generation strategies have focussed away from natural products. A new approach that uses natural-product recognition to drive an understanding of biological space might pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c21ac9aba36f60c4a84fb64bfe7deb9
https://doi.org/10.1002/cbic.200700035
https://doi.org/10.1002/cbic.200700035
Publikováno v:
Journal of Natural Products. 69:14-17
The relationship between a natural product's biosynthetic enzyme and its therapeutic target is unknown. The concept of protein fold topologies, as a determining factor in recognition, has been developed through molecular modeling techniques. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d222f2b46f0825d6d1089b4aa30552a6
https://doi.org/10.1021/np050229y
https://doi.org/10.1021/np050229y
Autor:
Anthony R. Carroll, Leanne Towerzey, Priscila de Almeida Leone, Ronald J. Quinn, Gordon J. King, Bernadette Marie McArdle, John N. A. Hooper, Gunther Kern, Steward Fisher
Publikováno v:
ChemInform. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0521ef5e29082c57f8d36ac88ef6385c
https://doi.org/10.1002/chin.200843201
https://doi.org/10.1002/chin.200843201
Publikováno v:
Subcellular Biochemistry ISBN: 9780387095943
Until recently, structural information about coronins was scarce and the earlier identification of five WD40 repeats gave rise to a structural prediction of a five-bladed β propeller for the N-terminal domain of these proteins. More detailed analyse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2123b7299f2aae6677e4e9ca22150d91
https://doi.org/10.1007/978-0-387-09595-0_6
https://doi.org/10.1007/978-0-387-09595-0_6
