Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Bernadette Hickey"'
Autor:
Déborah Merda, Arnaud Felten, Noémie Vingadassalon, Sarah Denayer, Yacine Titouche, Lucia Decastelli, Bernadette Hickey, Christos Kourtis, Hristo Daskalov, Michel-Yves Mistou, Jacques-Antoine Hennekinne
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Food contamination by staphylococcal enterotoxins (SEs) is responsible for many food poisoning outbreaks (FPOs) each year, and they represent the third leading cause of FPOs in Europe. SEs constitute a protein family with 27 proteins. However, enzyme
Externí odkaz:
https://doaj.org/article/96cc09d140a64c44a0fff687429c34ee
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 10 (2017)
Background: Plecanatide, with the exception of a single amino acid replacement, is identical to human uroguanylin and is approved in the United States for adults with chronic idiopathic constipation (CIC). This double-blind, placebo-controlled, phase
Externí odkaz:
https://doaj.org/article/13d128ce35eb4e6f9b8dcd50d1742408
Autor:
Arnaud Felten, Yacine Titouche, Sarah Denayer, Christos Kourtis, Michel-Yves Mistou, Jacques-Antoine Hennekinne, Noémie Vingadassalon, Déborah Merda, Hristo Daskalov, Bernadette Hickey, Lucia Decastelli
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 11 (2020)
Frontiers in Microbiology, Vol 11 (2020)
Food contamination by staphylococcal enterotoxins (SEs) is responsible for many food poisoning outbreaks (FPOs) each year, and they represent the third leading cause of FPOs in Europe. SEs constitute a protein family with 27 proteins. However, enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136c2cc667605e88e4197a3ea2727bfb
https://doi.org/10.3389/fmicb.2020.01483
https://doi.org/10.3389/fmicb.2020.01483
Publikováno v:
Therapeutic Advances in Gastroenterology
Therapeutic Advances in Gastroenterology, Vol 10 (2017)
Therapeutic Advances in Gastroenterology, Vol 10 (2017)
Background: Plecanatide, with the exception of a single amino acid replacement, is identical to human uroguanylin and is approved in the United States for adults with chronic idiopathic constipation (CIC). This double-blind, placebo-controlled, phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7144e4968958958951d455b2dc5b00
https://pubmed.ncbi.nlm.nih.gov/29147135
https://pubmed.ncbi.nlm.nih.gov/29147135
Autor:
Charlene Wu, Shaila S. Shabbir, Pat M. Woollard, Alan D. Borthwick, Simon Peace, Fabrizio Nerozzi, David E. Davies, Timothy D. Westfall, John Liddle, Wendy R. Irving, Deirdre Mary Bernadette Hickey, Joanne Philp, Christopher Charles Frederick Hamlett, Derek Pollard, Mark Pullen, David P. Brooks, Gerald P. McCafferty, Richard M. Edwards, Andrew M. Mason, Steve L. Sollis, Michael Allen, Anne M. Exall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:90-94
Optimisation of a series of oxazole diketopiperazines has led to the discovery of a very potent and selective oxytocin antagonist GSK221149A. GSK221149A has been shown to inhibit oxytocin-induced uterine contractions in the anaesthetised rat.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7169b86c2410cd3ad98037d3bf0d45c4
https://doi.org/10.1016/j.bmcl.2007.11.008
https://doi.org/10.1016/j.bmcl.2007.11.008
Autor:
Stephen C. McKeown, Thomas R. Littleton, Andrew J. Peat, Steve P. Watson, Aaron S. Goetz, Deirdre Mary Bernadette Hickey, David F. Corbett, Celia P. Briscoe, Eric C. Bigham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1584-1589
The discovery, synthesis and structure-activity relationship (SAR) of novel carboxylic acid agonists for GPR40 are described. Aryl propionic acid 1, identified from a high throughput screen, was selected for chemical exploration. Compound 2 was ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1710461fe4ffcfb7fb679fdb991df2ad
https://doi.org/10.1016/j.bmcl.2006.12.084
https://doi.org/10.1016/j.bmcl.2006.12.084
Publikováno v:
American Journal of Gastroenterology. 111:S248-S249
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d8f1ce2877ce8d6b9b91d97d91d26b7
https://doi.org/10.14309/00000434-201610001-00544
https://doi.org/10.14309/00000434-201610001-00544
Autor:
Bernadette Hickey, John David Lentz, Patrick Griffin, Laura Barrow, Maria Nualart, Philip B. Miner, Ramon Berenguer
Publikováno v:
Gastroenterology. 150:S497-S498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d8d66e7aa0ec9d6276813a53a9bbe77
https://doi.org/10.1016/s0016-5085(16)31713-9
https://doi.org/10.1016/s0016-5085(16)31713-9
Autor:
V.Ann Lewis, Ian Stansfield, Kevin J. Milliner, Ivan Leo Pinto, Jackie C. Bloomer, Steven J. Stanway, Stephen A. Smith, Josie A. Blackie, Colin J. Theobald, Beverley Hammond, Hung Yuan Cheng, Colin A. Leach, Maxine A. Taylor, Robert J. Ife, Richard L. Elliott, Deirdre Mary Bernadette Hickey, Murray J. B. Brown, Caroline M. Whittaker, Kitty Moores, Colin H. Macphee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2603-2606
The introduction of a functionalised amido substituent into a series of 1-(biphenylmethylacetamido)-pyrimidones has given a series of inhibitors of recombinant lipoprotein-associated phospholipase A(2) with sub-nanomolar potency and very encouraging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::543d3185255171f3d1d06440ebbf8160
https://doi.org/10.1016/s0960-894x(02)00473-0
https://doi.org/10.1016/s0960-894x(02)00473-0
Autor:
Patrick M. Woollard, Anne M. Exall, Deirdre Mary Bernadette Hickey, Fabrizio Nerozzi, Ian Edward David Smith, John Liddle, Dave E. Davies, Simon Peace, Timothy D. Westfall, Mark Pullen, Michael Allen, Alan D. Borthwick, Andrew M. Mason, Dinesh Stanislaus, Steve L. Sollis, Christopher Charles Frederick Hamlett, Derek Pollard
Publikováno v:
Journal of medicinal chemistry. 55(2)
A six-stage stereoselective synthesis of indanyl-7-(3'-pyridyl)-(3R,6R,7R)-2,5-diketopiperazines oxytocin antagonists from indene is described. SAR studies involving mono- and disubstitution in the 3'-pyridyl ring and variation of the 3-isobutyl grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0105f246aa79833007ec247c9dd297
https://pubmed.ncbi.nlm.nih.gov/22239250
https://pubmed.ncbi.nlm.nih.gov/22239250