Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Bernadette Byrne"'
Autor:
Cristina Cecchetti, Nicola J. Scull, Thotegowdanapalya C. Mohan, Yilmaz Alguel, Alexandra M. C. Jones, Alexander D. Cameron, Bernadette Byrne
Publikováno v:
FEBS Open Bio, Vol 11, Iss 6, Pp 1685-1694 (2021)
Integral membrane transporters play essential roles in the movement of substrates across biological membranes. One approach to produce transporters suitable for structural studies is to introduce mutations that reduce conformational flexibility and i
Externí odkaz:
https://doaj.org/article/56715d7483584625bc9688d1c06d7294
Autor:
Savvas Saouros, Thotegowdanapalya C. Mohan, Cristina Cecchetti, Silke Lehmann, Joseph D. Barrit, Nicola J. Scull, Paul Simpson, Yilmaz Alguel, Alexander D. Cameron, Alexandra M. E. Jones, Bernadette Byrne
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Boron has essential roles in plant growth and development. BOR proteins are key in the active uptake and distribution of boron, and regulation of intracellular boron concentrations. However, their mechanism of action remains poorly studied.
Externí odkaz:
https://doaj.org/article/c2c8b0b5c6a9433dae0794ffd203cba5
Autor:
Cristina Cecchetti, Jannik Strauss, Claudia Stohrer, Claire Naylor, Edward Pryor, Jeanette Hobbs, Simon Tanley, Adrian Goldman, Bernadette Byrne
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254118 (2021)
Membrane proteins have a range of crucial biological functions and are the target of about 60% of all prescribed drugs. For most studies, they need to be extracted out of the lipid-bilayer, e.g. by detergent solubilisation, leading to the loss of nat
Externí odkaz:
https://doaj.org/article/22e197f755e54af484c0e5dea3a85437
Autor:
Hazrat Hussain, Jonas S. Mortensen, Yang Du, Claudia Santillan, Orquidea Ribeiro, Juyeon Go, Parameswaran Hariharan, Claus J. Loland, Lan Guan, Brian K. Kobilka, Bernadette Byrne, Pil Seok Chae
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract High-resolution membrane protein structures are essential for understanding the molecular basis of diverse biological events and important in drug development. Detergents are usually used to extract these bio-macromolecules from the membrane
Externí odkaz:
https://doaj.org/article/087002c5c6c2415c9ebf4a39ab6e0c4d
Autor:
Yilmaz Alguel, Sotiris Amillis, James Leung, George Lambrinidis, Stefano Capaldi, Nicola J. Scull, Gregory Craven, So Iwata, Alan Armstrong, Emmanuel Mikros, George Diallinas, Alexander D. Cameron, Bernadette Byrne
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
UapA is a uric acid/xanthine H+symporter from a filamentous fungus. Here, the authors solve the crystal structure of the transporter in complex with xanthine revealing it to be a dimer, and this homodimerisation is proposed to be important for functi
Externí odkaz:
https://doaj.org/article/b41fb7a665c043f9b09f439ddeb1be16
Autor:
Emil Carlsson, Joanne E Thwaite, Dominic C Jenner, Abigail M Spear, Helen Flick-Smith, Helen S Atkins, Bernadette Byrne, Jeak Ling Ding
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158575 (2016)
Toll-like receptors (TLRs) recognise invading pathogens and mediate downstream immune signalling via Toll/IL-1 receptor (TIR) domains. TIR domain proteins (Tdps) have been identified in multiple pathogenic bacteria and have recently been implicated a
Externí odkaz:
https://doaj.org/article/8f660a7c204144b4a51f1b89da4b7647
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e89613 (2014)
One successful approach to obtaining high-resolution crystal structures of G-protein coupled receptors is the introduction of thermostabilising mutations within the receptor. This technique allows the generation of receptor constructs stabilised into
Externí odkaz:
https://doaj.org/article/667109646177458f8e4c0edaa6f26233
Autor:
Lubna Ghani, Xiang Zhang, Chastine F. Munk, Parameswaran Hariharan, Baoliang Lan, Hong Sik Yun, Bernadette Byrne, Lan Guan, Claus J. Loland, Xiangyu Liu, Pil Seok Chae
Publikováno v:
Bioconjugate Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::418eed307d169995df0ed0b9ef7c426c
https://doi.org/10.1021/acs.bioconjchem.3c00042
https://doi.org/10.1021/acs.bioconjchem.3c00042
Autor:
James W. Beattie, Alena Istrate, Annabelle Lu, Cameron Marshall, Ruth C. Rowland-Jones, Monika Farys, Sergei G. Kazarian, Bernadette Byrne
Monoclonal antibodies (mAbs) are used extensively as biotherapeutics for chronic and acute conditions. Production of mAbs is lengthy and expensive, with protein A affinity capture the most costly step, due both to the nature of the resin and its mark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3bd5ffd2992c327a7a7507fbacb737c
http://hdl.handle.net/10044/1/100530
http://hdl.handle.net/10044/1/100530
Autor:
Hyun Sung Lee, Manabendra Das, Florian Mahler, Waqar Ahmed, Haoqing Wang, Jonas S. Mortensen, Parameswaran Hariharan, Lubna Ghani, Bernadette Byrne, Lan Guan, Claus J. Loland, Sandro Keller, Pil Seok Chae
Publikováno v:
Chemistry, an Asian journal.
Detergents have been major contributors to membrane-protein structural study for decades. However, membrane proteins solubilized in conventional detergents tend to aggregate or denature over time. Stability of large eukaryotic membrane proteins with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b011ce09f3c4e2a42edaf8a8d7baa4
https://pubmed.ncbi.nlm.nih.gov/36253323
https://pubmed.ncbi.nlm.nih.gov/36253323