Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bernadette Bertin"'
Autor:
Catherine Burnouf, Malika Ouaged, Bernadette Bertin, C. Bertrand, Marie-Pierre Pruniaux, Vincent Lagente, Marie-Noelle Rocher, Anita Bouget, Christine Julien-Larose, Christelle Leportier, Annette M. Doherty, François Moreau, Jean-Pierre Dubuit, Brigitte Martin
Publikováno v:
Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2010, 24 (1), pp.73-82. ⟨10.1111/j.1472-8206.2009.00725.x⟩
Fundamental & Clinical Pharmacology
Fundamental & Clinical Pharmacology, 2010, 24 (1), pp.73-82. ⟨10.1111/j.1472-8206.2009.00725.x⟩
Fundamental and Clinical Pharmacology, Wiley, 2010, 24 (1), pp.73-82. ⟨10.1111/j.1472-8206.2009.00725.x⟩
Fundamental & Clinical Pharmacology
Fundamental & Clinical Pharmacology, 2010, 24 (1), pp.73-82. ⟨10.1111/j.1472-8206.2009.00725.x⟩
International audience; The anti-inflammatory effects of CI-1044 and of the other selective PDE4 inhibitors rolipram and cilomilast were investigated in Brown-Norway (BN) rats, against lipopolysaccharide-induced tumor necrosis factor alpha (TNFalpha)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2e2c572a175cb5ec0fa97d6afbfabd
https://doi.org/10.1111/j.1472-8206.2009.00725.x
https://doi.org/10.1111/j.1472-8206.2009.00725.x
Autor:
Bernadette Bertin, Anita Tertre, Nga Pham, Françoise Berlioz-Seux, Moulay Idrissi, Patrick Bernardelli, Arnaud Descours, Edwige Lorthiois, Mei Li, Pierre Ducrot, Chrystelle Oliveira, Magali Coupe, François Moreau, Eric Chevalier, Fabrice Vergne, Emmanuelle Proust, Patrick Berna, Abdel-Kader Mafroud
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4627-4631
The optimization of 5,8-disubstituted spirocyclohexane-quinazolinones into potent, selective, soluble PDE7 inhibitors with acceptable in vivo pharmacokinetic parameters is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b645e96fe4aad63c13696befaf5e5e
https://doi.org/10.1016/j.bmcl.2004.07.010
https://doi.org/10.1016/j.bmcl.2004.07.010
Autor:
Magali Coupe, Bernadette Bertin, Arnaud Descours, François Moreau, Patrick Bernardelli, Edwige Lorthiois, Patricia Soulard, Patrick Berna, Roger Wrigglesworth, Anita Tertre, Abdel-Kader Mafroud, Lamia Heuze, Emmanuelle Proust, Chrystelle Oliveira, Fabrice Vergne, Moulay Idrissi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4623-4626
The synthesis and SAR studies of spiroquinazolinones as novel PDE7 inhibitors are discussed. The best compounds from the series displayed nanomolar inhibitory affinity and were selective versus other PDE isoenzymes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe38a476d80dbc5773e675bdb38f8ed6
https://doi.org/10.1016/j.bmcl.2004.07.011
https://doi.org/10.1016/j.bmcl.2004.07.011
Autor:
Frédéric Féru, Yves Pascal, Marie-Pierre Pruniaux, Malika Ouagued, Charles R Andrianjara, Adrian Payne, Bernadette Bertin, Nadine Avenel, Sophie Lardon, Eric Auclair, Alain Calvet, Corinne M. Szilagyi, Indres Moodley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:35-38
A novel series of benzodiazepine derivatives have been discovered as inhibitors of PDE4 enzymes. We have found that our compounds are selective versus other PDE enzymes, and that the activity can be modulated by specific structural modifications. One
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58fdcefa8ef83d08b4e3c6c657ccd29
https://doi.org/10.1016/s0960-894x(99)00573-9
https://doi.org/10.1016/s0960-894x(99)00573-9
Autor:
Bernadette Bertin, Patrick Bernardelli, Moulay Idrissi, Edwige Lorthiois, Nga Pham, Patrick Berna, Roger Wrigglesworth, Magali Coupe, Frederique Royer, Jennifer K. Schellhaas, Emmanuelle Proust, Mark R. Barvian, Anita Tertre, Fabrice Vergne, François Moreau, Abdel-Kader Mafroud, Patricia Soulard, Chrystelle Oliveira
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(18)
The synthesis and SAR studies of a series of structurally novel small molecule inhibitors of PDE7 are discussed. The best compounds from the series displayed low nanomolar inhibitory activity and are selective versus PDE4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f859f278c373d4d7ecfc9939391bb07
https://pubmed.ncbi.nlm.nih.gov/15324874
https://pubmed.ncbi.nlm.nih.gov/15324874
Autor:
Eric Auclair, Veronique Fasquelle, Annette M. Doherty, Kam Chan, Stéphane Milano, Emmanuelle Lallier, Bernadette Bertin, Malika Ouagued, Marie-Noelle Rocher, Catherine Burnouf, Christèle Bigot, Brigitte Martin, Roger Wrigglesworth, Marie-Pierre Pruniaux, Richard B. Gilbertsen, Frederic Feru, Jocelyne Puaud, Nadine Avenel, Jacquie Maignel, Yves Pascal, Adel Kebsi, Calvet Alain Pierre, Henry Jacobelli, Christophe Terrasse, Corinne Durand
Publikováno v:
Journal of medicinal chemistry. 43(25)
The synthesis, structure-activity relationships, and biological properties of a novel series of potent and selective phosphodiesterase type 4 (PDE4) inhibitors are described. These new aminodiazepinoindoles displayed in vitro PDE4 activity with submi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e0a99010577cf538d277f8e060d10e
https://pubmed.ncbi.nlm.nih.gov/11123995
https://pubmed.ncbi.nlm.nih.gov/11123995
