Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bernadeta Dadonaite"'
Autor:
David J Bacsik, Bernadeta Dadonaite, Andrew Butler, Allison J Greaney, Nicholas S Heaton, Jesse D Bloom
Publikováno v:
eLife, Vol 12 (2023)
The ultimate success of a viral infection at the cellular level is determined by the number of progeny virions produced. However, most single-cell studies of infection quantify the expression of viral transcripts and proteins, rather than the amount
Externí odkaz:
https://doaj.org/article/9127c1486737475b8b8868e7d39955cd
Autor:
Ariana Ghez Farrell, Bernadeta Dadonaite, Allison J. Greaney, Rachel Eguia, Andrea N. Loes, Nicholas M. Franko, Jennifer Logue, Juan Manuel Carreño, Anass Abbad, Helen Y. Chu, Kenneth A. Matreyek, Jesse D. Bloom
Publikováno v:
Viruses, Vol 14, Iss 9, p 2061 (2022)
Neutralization assays are experimental surrogates for the effectiveness of infection- or vaccine-elicited polyclonal antibodies and therapeutic monoclonal antibodies targeting SARS-CoV-2. However, the measured neutralization can depend on the details
Externí odkaz:
https://doaj.org/article/486b860d8768441aa8e76c6a82830caf
Autor:
Tyler N. Starr, Allison J. Greaney, William W. Hannon, Andrea N. Loes, Kevin Hauser, Josh R. Dillen, Elena Ferri, Ariana Ghez Farrell, Bernadeta Dadonaite, Matthew McCallum, Kenneth A. Matreyek, Davide Corti, David Veesler, Gyorgy Snell, Jesse D. Bloom
Publikováno v:
Science. 377:420-424
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved variants with substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin-converting enzyme 2 (ACE2) receptor and recognition by antibodies
Autor:
Lihong Liu, Ryan G. Casner, Yicheng Guo, Qian Wang, Sho Iketani, Jasper Fuk-Woo Chan, Jian Yu, Bernadeta Dadonaite, Manoj S. Nair, Hiroshi Mohri, Eswar R. Reddem, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kwok-Yung Yuen, Zizhang Sheng, Yaoxing Huang, Jesse D. Bloom, Lawrence Shapiro, David D. Ho
Publikováno v:
bioRxiv
SUMMARYSARS-CoV-2 continues to evolve and evade most existing neutralizing antibodies, including all clinically authorized antibodies. We have isolated and characterized two human monoclonal antibodies, 12-16 and 12-19, which exhibited neutralizing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8dcb7a3556cd7c28fe78eb9ee02c16
https://europepmc.org/articles/PMC10120718/
https://europepmc.org/articles/PMC10120718/
Autor:
Caelan E. Radford, Philipp Schommers, Lutz Gieselmann, Katharine H. D. Crawford, Bernadeta Dadonaite, Timothy C. Yu, Adam S. Dingens, Julie Overbaugh, Florian Klein, Jesse D. Bloom
Publikováno v:
bioRxiv
Understanding the specificities of human serum antibodies that broadly neutralize HIV can inform prevention and treatment strategies. Here we describe a deep mutational scanning system that can measure the effects of combinations of mutations to HIV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0478771c3ce8ea4658bb2834d04090
https://europepmc.org/articles/PMC10055425/
https://europepmc.org/articles/PMC10055425/
Autor:
Jamie Guenthoer, Michelle Lilly, Tyler N. Starr, Bernadeta Dadonaite, Klaus N. Lovendahl, Jacob T. Croft, Caitlin I. Stoddard, Vrasha Chohan, Shilei Ding, Felicitas Ruiz, Mackenzie S. Kopp, Andrés Finzi, Jesse D. Bloom, Helen Y. Chu, Kelly K. Lee, Julie Overbaugh
Publikováno v:
bioRxiv
The antiviral benefit of antibodies can be compromised by viral escape especially for rapidly evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to counter newly emerging, diverse strains. Discovery of such antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae94c3d8b7897df9cf301224e370d000
https://doi.org/10.1101/2022.12.15.520606
https://doi.org/10.1101/2022.12.15.520606
Autor:
Thomas A. Desautels, Kathryn T. Arrildt, Adam T. Zemla, Edmond Y. Lau, Fangqiang Zhu, Dante Ricci, Stephanie Cronin, Seth J. Zost, Elad Binshtein, Suzanne M. Scheaffer, Bernadeta Dadonaite, Brenden K. Petersen, Taylor B. Engdahl, Elaine Chen, Laura S. Handal, Lynn Hall, John W. Goforth, Denis Vashchenko, Sam Nguyen, Dina R. Weilhammer, Jacky Kai-Yin Lo, Bonnee Rubinfeld, Edwin A. Saada, Tracy Weisenberger, Tek-Hyung Lee, Bradley Whitener, James B. Case, Alexander Ladd, Mary S. Silva, Rebecca M. Haluska, Emilia A. Grzesiak, Christopher G. Earnhart, Svetlana Hopkins, Thomas W. Bates, Larissa B. Thackray, Brent W. Segelke, Antonietta Maria Lillo, Shivshankar Sundaram, Jesse Bloom, Michael S. Diamond, James E. Crowe, Robert H. Carnahan, Daniel M. Faissol
Publikováno v:
bioRxiv : the preprint server for biology.
The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs1–3, but also revealed how quickly viral escape can curtail effective options4, 5. With the emergence of the SARS-CoV-2 Omicron variant in
Autor:
Bernadeta Dadonaite, Katharine H D Crawford, Caelan E Radford, Ariana G Farrell, Timothy C Yu, William W Hannon, Panpan Zhou, Raiees Andrabi, Dennis R Burton, Lihong Liu, David D. Ho, Richard A. Neher, Jesse D Bloom
Publikováno v:
bioRxiv
A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and functional effects of emerging mutations in the viral spike protein. Here we describe a new deep mutational scanning platform based on non-replicative pseudotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b9ff3a1fcade6fdf7b7b300eb18831
https://europepmc.org/articles/PMC9580381/
https://europepmc.org/articles/PMC9580381/
Autor:
Bernadeta Dadonaite, Katharine H.D. Crawford, Caelan E. Radford, Ariana G. Farrell, Timothy C. Yu, William W. Hannon, Panpan Zhou, Raiees Andrabi, Dennis R. Burton, Lihong Liu, David D. Ho, Helen Y. Chu, Richard A. Neher, Jesse D. Bloom
Publikováno v:
Cell. 186:1263-1278.e20
Autor:
Jan Rehwinkel, Rachel E. Rigby, Jenny Klintman, Kim De Keersmaecker, Anna Schuh, Andrei Chabes, Anne Bridgeman, Peter Hillmen, Bernadeta Dadonaite, Tamara Davenne, Sushma Sharma, Chiara Cursi
Summary The anti-leukaemia agent forodesine causes cytotoxic overload of intracellular deoxyguanosine triphosphate (dGTP) but is efficacious only in a subset of patients. We report that SAMHD1, a phosphohydrolase degrading deoxyribonucleoside triphos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273fdc4fc542fe240b0e400802e47003
https://doi.org/10.1101/2020.02.17.951517
https://doi.org/10.1101/2020.02.17.951517