Study of metalation of thioredoxin by gold(I) therapeutic compounds using combined liquid chromatography/capillary electrophoresis with inductively coupled plasma/electrospray MS/MS detection.

Autor: Bernabeu De Maria, Mikel, Matczuk, Magdalena, Tesauro, Diego, Saviano, Michele, Sikorski, Jacek, Chiappetta, Giovanni, Godin, Simon, Szpunar, Joanna, Lobinski, Ryszard, Ronga, Luisa

Publikováno v: Analytical & Bioanalytical Chemistry; May2024, Vol. 416 Issue 11, p2819-2833, 15p

N-Heterocyclic Carbene (NHC) Gold(I) complexes targeting the Thioredoxin System: a mass spectrometry study

Autor: Diego Tesauro, Mikel Bernabeu De Maria, Giovanni Chiappetta, Michele Saviano, Ryszard Lobinski, Luisa Ronga

Thioredoxin (Trx) and Thioredoxin Reductase (TrxR) enzymes are essential constituents of the Trx system involved in the cellular redox regulation network. This mitochondrial apparatus, in recent years, has been recognized as an important modulator of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::61438694e5cee18e471da46fbf42d61d
https://hdl.handle.net/11588/908513

Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9- Bis [(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux.

Autor: Guillon J; Faculty of Pharmacy, University of Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, F-33000 Bordeaux, France., Cohen A; Faculty of Pharmacy, University of Aix-Marseille, IRD, AP-HM, SSA, VITROME, F-13005 Marseille, France., Boudot C; Faculty of Pharmacy, Institute of Neuroepidemiology and Tropical Neurology, University of Limoges, INSERM U1094, F-87025 Limoges, France., Monic S; Faculty of Pharmacy, University of Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, F-33000 Bordeaux, France., Savrimoutou S; Faculty of Pharmacy, University of Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, F-33000 Bordeaux, France., Moreau S; Faculty of Pharmacy, University of Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, F-33000 Bordeaux, France., Albenque-Rubio S; Faculty of Pharmacy, University of Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, F-33000 Bordeaux, France., Lafon-Schmaltz C; Faculty of Pharmacy, University of Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, F-33000 Bordeaux, France., Dassonville-Klimpt A; Faculty of Pharmacy, Agents Infectieux, Résistance et Chimiothérapie (AGIR), UR 4294, UFR de Pharmacie, University of Picardie Jules Verne, F-80037Amiens, France., Mergny JL; Laboratoire d'Optique et Biosciences, Institut Polytechnique de Paris, Ecole Polytechnique, CNRS, INSERM, F- 91128 Palaiseau, France., Ronga L; Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM, F-64012 Pau, France., Bernabeu de Maria M; Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM, F-64012 Pau, France., Lamarche J; Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM, F-64012 Pau, France., Lago CD; University of Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, IECB, F-33600 Pessac, France., Largy E; University of Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, IECB, F-33600 Pessac, France., Gabelica V; University of Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, IECB, F-33600 Pessac, France., Moukha S; Centre de Recherche Cardio-thoracique de Bordeaux (CRCTB), UMR U1045 INSERM, PTIB-Hôpital Xavier Arnozan, F-33600 Pessac, France.; INRAE Bordeaux Aquitaine, F- 33140 Villenave-d'Ornon, France., Dozolme P; Centre de Recherche Cardio-thoracique de Bordeaux (CRCTB), UMR U1045 INSERM, PTIB-Hôpital Xavier Arnozan, F-33600 Pessac, France.; INRAE Bordeaux Aquitaine, F- 33140 Villenave-d'Ornon, France., Agnamey P; Faculty of Pharmacy, Agents Infectieux, Résistance et Chimiothérapie (AGIR), UR 4294, UFR de Pharmacie, University of Picardie Jules Verne, F-80037Amiens, France., Azas N; Faculty of Pharmacy, University of Aix-Marseille, IRD, AP-HM, SSA, VITROME, F-13005 Marseille, France., Mullié C; Faculty of Pharmacy, Agents Infectieux, Résistance et Chimiothérapie (AGIR), UR 4294, UFR de Pharmacie, University of Picardie Jules Verne, F-80037Amiens, France., Courtioux B; Faculty of Pharmacy, Institute of Neuroepidemiology and Tropical Neurology, University of Limoges, INSERM U1094, F-87025 Limoges, France., Sonnet P; Faculty of Pharmacy, Agents Infectieux, Résistance et Chimiothérapie (AGIR), UR 4294, UFR de Pharmacie, University of Picardie Jules Verne, F-80037Amiens, France.

Publikováno v: Pathogens (Basel, Switzerland) [Pathogens] 2022 Nov 13; Vol. 11 (11). Date of Electronic Publication: 2022 Nov 13.