Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Berna Özçelik"'
1
Akademický článek
Inhibition of Monoamine Oxidases by Pyridazinobenzylpiperidine Derivatives
Autor: Jong Min Oh, Yaren Nur Zenni, Zeynep Özdemir, Sunil Kumar, Semanur Kılıç, Mevlüt Akdağ, Azime Berna Özçelik, Hoon Kim, Bijo Mathew
Publikováno v: Molecules, Vol 29, Iss 13, p 3097 (2024)
Monoamine oxidase inhibitors (MAOIs) have been crucial in the search for anti-neurodegenerative medications and continued to be a vital source of molecular and mechanistic diversity. Therefore, the search for selective MAOIs is one of the main areas
Externí odkaz: https://doaj.org/article/00b9f4a63e2746febdf61997361e9558
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2
Akademický článek
Synthesis and biological evaluation of new 3(2H)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells
Autor: Zeynep Özdemir, Semra Utku, Bijo Mathew, Simone Carradori, Giustino Orlando, Simonetta Di Simone, Mehmet Abdullah Alagöz, Azime Berna Özçelik, Mehtap Uysal, Claudio Ferrante
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1100-1109 (2020)
Novel 3(2H)-pyridazinone derivatives were designed, synthesised in satisfactory yields and evaluated in different experimental assays to assess their preliminary toxicity in vivo and anti-proliferative effects against HCT116 cell lines in vitro. Arte
Externí odkaz: https://doaj.org/article/77aec80aff0d46378d800e0973455166
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3
Akademický článek
Evaluation of genotoxic effects of 3-methyl-5-(4-carboxycyclohexylmethyl)-tetrahydro-2H-1,3,5-thiadiazine-2-thione on human peripheral lymphocytes
Autor: Ece Avuloğlu-Yılmaz, Deniz Yüzbaşıoğlu, Azime Berna Özçelik, Seyhan Ersan, Fatma Ünal
Publikováno v: Pharmaceutical Biology, Vol 55, Iss 1, Pp 1228-1233 (2017)
Context: Tranexamic acid is commonly used for curing abnormal bleeding in a variety of diseases. In a previous study, 12 different tetrahydro-2H-1,3,5-thiadiazine derivatives were synthesized from the amine group of tranexamic acid. Their antifibrino
Externí odkaz: https://doaj.org/article/6240af07704d45bc800639790c1ef803
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7
Inhibition of Cholinesterases by Benzothiazolone Derivatives
Autor: Mehmet Abdullah Alagöz, Seong-Min Kim, Jong Min Oh, Gülnur Arslan, Zeynep Özdemir, Suat Sari, Azime Berna Özçelik, Tijen Önkol, Daniela Trisciuzzi, Orazio Nicolotti, Hoon Kim, Bijo Mathew
Publikováno v: Processes; Volume 10; Issue 9; Pages: 1872
Thirteen benzothiazolone derivatives (M1–M13) were synthesized and evaluated for their inhibitory activity against cholinesterases (ChEs) and monoamine oxidases (MAOs). All the compounds inhibited ChEs more effectively than MAOs. In addition, most
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5359a2e05e97c3fda4bed6dd272136c
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8
Synthesis of ( p‐ tolyl)‐3(2 H )pyridazinone Derivatives as Novel Acetylcholinesterase Inhibitors
Autor: İrem Bozbey Merde, Gülce Taşkor Önel, Burçin Türkmenoğlu, Şule Gürsoy, Esra Dilek, Azime Berna Özçelik, Mehtap Uysal
Publikováno v: ChemistrySelect. 7
In this study, a series of N-substituted-(p-tolyl)pyridazin-3(2H)-one derivatives were synthesized and evaluated for their AChE inhibitory activity. The chemical structures of novel compounds 5(a-m) were confirmed by H-1-NMR, C-13-NMR, IR and HRMS an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a868ee43c60e51161cc8611584d8bf
https://doi.org/10.1002/slct.202201606
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9
Design, synthesis, and aldose reductase inhibitory effect of some novel carboxylic acid derivatives bearing 2-substituted-6-aryloxo-pyridazinone moiety
Autor: Mevlüt Akdağ, Azime Berna Özçelik, Yeliz Demir, Şükrü Beydemir
© 2022 Elsevier B.V.The polyol pathway is a two-step metabolic pathway in which glucose is reduced to sorbitol and then converted to fructose. The first and rate limiting enzyme of this pathway, aldose reductase (ALR2), is a drug target for treating
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86f359ea8660b588516bd2d7701369a
https://avesis.gazi.edu.tr/publication/details/e65b71f2-eb7c-438c-bc39-85af47bd36af/oai
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10
A POTENTIAL TARGET FOR DEVOLOPING BROAD SPECTRUM ANTICANCERS: HEXOKINASE-II
Autor: Mevlüt AKDAĞ, Azime Berna ÖZÇELİK
Publikováno v: Volume: 46, Issue: 1 182-192
Journal of Faculty of Pharmacy of Ankara University
Amaç: Kanser hücrelerinin glikoza duydukları ihtiyaç sonucu solunumla ilgili metabolik yolaklarını yeniden düzenlemesi, kanser hücrelerini normal hücrelerden ayıran önemli değişimlerden biridir ve bu değişim ilk olarak 1920’li yılla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdece42038202569a6df279483090001
https://dergipark.org.tr/tr/pub/jfpanu/issue/68300/978805
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