Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo.

Autor: Vecchio LM; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Sullivan P; Autonomic Medicine Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological, Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Dunn AR; The Jackson Laboratory. Bar Harbor, Maine, USA., Bermejo MK; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Fu R; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA., Masoud ST; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Gregersen E; Danish Research Institute of Translational Neuroscience - DANDRITE, Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus C., Denmark., Urs NM; Department of Pharmacology and Therapeutics, University of Florida, Gainsville, FL, USA., Nazari R; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Jensen PH; Danish Research Institute of Translational Neuroscience - DANDRITE, Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus C., Denmark., Ramsey A; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Goldstein DS; Autonomic Medicine Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological, Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Miller GW; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Medical Centre, New York, NY, USA., Salahpour A; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Publikováno v: Journal of neurochemistry [J Neurochem] 2021 Aug; Vol. 158 (4), pp. 960-979. Date of Electronic Publication: 2021 Jun 12.

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.

Autor: Masoud ST; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle - Rm 4302, Toronto, ON M5S 1A8, Canada. Electronic address: shababa.masoud@mail.utoronto.ca., Vecchio LM; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle - Rm 4302, Toronto, ON M5S 1A8, Canada. Electronic address: laura.vecchio@mail.utoronto.ca., Bergeron Y; Department of Medical Biology, Université du Québec à Trois-Rivières, QC G9A 5H7 Canada. Electronic address: yan.bergeron@uqtr.ca., Hossain MM; Environmental and Occupational Health Sciences Institute, Rutgers, 170 Frelinghuysen Road, EOHSI 340, Piscataway, NJ 08854, USA. Electronic address: mhossain@eohsi.rutgers.edu., Nguyen LT; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle - Rm 4302, Toronto, ON M5S 1A8, Canada. Electronic address: Lien.nguyen@mail.utoronto.ca., Bermejo MK; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle - Rm 4302, Toronto, ON M5S 1A8, Canada. Electronic address: kristel.bermejo@mail.utoronto.ca., Kile B; Department of Chemistry, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: bkile04@gmail.com., Sotnikova TD; Neuroscience and Brain Technologies, Italian Institute of Technology, Via Morego 30, Genova 16163, Italy; Faculty of Biology and Soil Science, St. Petersburg State University, St. Petersburg 199034, Russia. Electronic address: tatiana.sotnikova@iit.it., Siesser WB; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: billsiesser@gmail.com., Gainetdinov RR; Neuroscience and Brain Technologies, Italian Institute of Technology, Via Morego 30, Genova 16163, Italy; Faculty of Biology and Soil Science, St. Petersburg State University, St. Petersburg 199034, Russia; Skolkovo Institute of Science and Technology, Skolkovo, 143025 Moscow Region, Russia. Electronic address: Raul.Gainetdinov@iit.it., Wightman RM; Department of Chemistry, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: rmw@unc.edu., Caron MG; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: marc.caron@duke.edu., Richardson JR; Environmental and Occupational Health Sciences Institute, Rutgers, 170 Frelinghuysen Road, EOHSI 340, Piscataway, NJ 08854, USA. Electronic address: jricha3@eohsi.rutgers.edu., Miller GW; Department of Environmental Health, Emory University, Atlanta, GA 30322, USA; Department of Pharmacology, Emory University, Atlanta, GA 30322, USA; Department of Neurology, Emory University, Atlanta, GA 30322, USA. Electronic address: gwmille@emory.edu., Ramsey AJ; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle - Rm 4302, Toronto, ON M5S 1A8, Canada. Electronic address: a.ramsey@utoronto.ca., Cyr M; Department of Medical Biology, Université du Québec à Trois-Rivières, QC G9A 5H7 Canada. Electronic address: Michel.Cyr@uqtr.ca., Salahpour A; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle - Rm 4302, Toronto, ON M5S 1A8, Canada. Electronic address: ali.salahpour@utoronto.ca.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2015 Feb; Vol. 74, pp. 66-75. Date of Electronic Publication: 2014 Oct 30.

N-terminal tagging of the dopamine transporter impairs protein expression and trafficking in vivo.

Autor: Vecchio LM; Department of Pharmacology, University of Toronto: Medical Sciences Building, Room 4302, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address: laura.vecchio@mail.utoronto.ca., Bermejo MK; Department of Pharmacology, University of Toronto: Medical Sciences Building, Room 4302, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address: kristel.bermejo@mail.utoronto.ca., Beerepoot P; Department of Pharmacology, University of Toronto: Medical Sciences Building, Room 4302, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address: pieter.beerepoot@mail.utoronto.ca., Ramsey AJ; Department of Pharmacology, University of Toronto: Medical Sciences Building, Room 4302, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address: a.ramsey@utoronto.ca., Salahpour A; Department of Pharmacology, University of Toronto: Medical Sciences Building, Room 4302, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address: ali.salahpour@utoronto.ca.

Publikováno v: Molecular and cellular neurosciences [Mol Cell Neurosci] 2014 Jul; Vol. 61, pp. 123-32. Date of Electronic Publication: 2014 Jun 02.