Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Berma M. Kinsey"'
Autor:
Muthu Ramakrishnan, Fernando Alves De Melo, Berma M Kinsey, John E Ladbury, Thomas R Kosten, Frank M Orson
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40518 (2012)
Despite progress in cocaine immunotherapy, the kinetic and thermodynamic properties of antibodies which bind to cocaine and its metabolites are not well understood. It is also not clear how the interactions between them differ in a complex matrix suc
Externí odkaz:
https://doaj.org/article/6380eac9b7fb4218b97709fa761f598e
Autor:
Yan Wu, Ernest D. Lykissa, Zhen Huang, Patrick W. O'Malley, Frank M. Orson, Therese A. Kosten, Kevin J. Winoske, Reetakshi Arora, Berma M. Kinsey, Thomas R. Kosten, Naga Naidu, Joseph A. Cox, Xiaoyun Y. Shen, Colin N. Haile
Publikováno v:
The American Journal on Addictions. 24:748-755
Background and Objectives We previously reported that an anti-methamphetamine (MA) vaccine attenuated drug-conditioned effects in mice, but it used a carrier protein and adjuvant not available for clinical use. Here we produced a vaccine with the sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e13378866317bad8f16fc0af5c7d8e6
https://doi.org/10.1111/ajad.12307
https://doi.org/10.1111/ajad.12307
Publikováno v:
The American Journal on Addictions. 23:604-607
Background and Objectives Immunotherapy for drug addiction is being investigated in several laboratories but most studies are conducted in animals of one sex. Yet, women show heightened immune responses and are more likely to develop autoimmune disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ab2a385525af0105a84434f24560353
https://doi.org/10.1111/j.1521-0391.2014.12152.x
https://doi.org/10.1111/j.1521-0391.2014.12152.x
Autor:
Berma M. Kinsey
Publikováno v:
Therapeutic Advances in Vaccines. 2:106-117
Drug addiction is a serious problem worldwide. One therapy being investigated is vaccines against drugs of abuse. The antibodies elicited against the drug can take up the drug and prevent it from reaching the reward centers in the brain. Few such vac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502a571d2e6eab9aa0911ca1a30f8b22
https://doi.org/10.1177/2051013614537818
https://doi.org/10.1177/2051013614537818
Autor:
Rana A. K. Singh, Stephen Brimijoin, Rongfu Wang, Thomas R. Kosten, Helen Yicheng Wang, Berma M. Kinsey, Frank M. Orson, Muthu Ramakrishnan
Publikováno v:
Expert Opinion on Biological Therapy. 14:1271-1283
Addiction to cocaine is a major problem around the world, but especially in developed countries where the combination of wealth and user demand has created terrible social problems. Although only some users become truly addicted, those who are often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a9eee4968176774bbf1eec21dbc42d
https://doi.org/10.1517/14712598.2014.920319
https://doi.org/10.1517/14712598.2014.920319
Publikováno v:
British Journal of Clinical Pharmacology. 77:368-374
While the worldwide prevalence of cocaine use remains significant, medications, or small molecule approaches, to treat drug addictions have met with limited success. Anti-addiction vaccines, on the other hand, have demonstrated great potential for tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1436bd70fd32f1294f1c30599ced3199
https://doi.org/10.1111/bcp.12115
https://doi.org/10.1111/bcp.12115
Autor:
Xiaoyun Y. Shen, Therese A. Kosten, Thomas R. Kosten, Berma M. Kinsey, Frank M. Orson, Angel Y. Lopez
Publikováno v:
Drug and Alcohol Dependence. 129:41-48
Background Vaccines have treatment potential for methamphetamine (MA) addiction. We tested whether a conjugate vaccine against MA (succinyl-methamphetamine-keyhole limpet hemocyanin carrier protein; SMA-KLH) would generate MA antibodies and alter MA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66a99799d12d3284f99d1330ac7308a
https://doi.org/10.1016/j.drugalcdep.2012.09.007
https://doi.org/10.1016/j.drugalcdep.2012.09.007
Autor:
Yang Gao, Liyi Geng, Xiaoyun Shen, Berma M. Kinsey, Thomas R. Kosten, Stephen Brimijoin, Frank M. Orson
Publikováno v:
Chemico-Biological Interactions. 203:208-211
In developing an vivo drug-interception therapy to treat cocaine abuse and hinder relapse into drug seeking provoked by re-encounter with cocaine, two promising agents are: (1) a cocaine hydrolase enzyme (CocH) derived from human butyrylcholinesteras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e8e8c379c07ef3a295c63c57948ab1
https://doi.org/10.1016/j.cbi.2012.08.006
https://doi.org/10.1016/j.cbi.2012.08.006
Publikováno v:
Biologics to Treat Substance Use Disorders ISBN: 9783319231495
Small molecules are unable to stimulate the immune system by themselves, and so require conjugation to a larger structure, i.e., a carrier molecule (often a protein) to enable effective engagement of immune cell receptors that can initiate adaptive i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8ffc0d5342d844b1a9303fd328ef22e
https://doi.org/10.1007/978-3-319-23150-1_16
https://doi.org/10.1007/978-3-319-23150-1_16
Publikováno v:
Chemico-Biological Interactions. 187:421-424
Cocaine access to brain tissue and associated cocaine-induced behaviors are substantially reduced in rats and mice by significant plasma levels of an enzyme that rapidly metabolizes the drug. Similar results have been obtained in rodents and humans w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f842bc20bb40eb10a3346eb09cef5f79
https://doi.org/10.1016/j.cbi.2010.02.036
https://doi.org/10.1016/j.cbi.2010.02.036