A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity.

Autor: Pamies D; Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore, USA., Barreras P; Department of Neurology, Johns Hopkins University, Baltimore, USA.; Division of Neuroimmunology, Johns Hopkins University, Baltimore, USA., Block K; Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore, USA., Makri G; Department of Neurology, Johns Hopkins University, Baltimore, USA.; Institute for Cell Engineering, Johns Hopkins University, Baltimore, USA., Kumar A; Department of Neurology, Johns Hopkins University, Baltimore, USA.; Division of Neuroimmunology, Johns Hopkins University, Baltimore, USA., Wiersma D; Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore, USA., Smirnova L; Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore, USA., Zang C; Department of Neurology, Johns Hopkins University, Baltimore, USA.; Institute for Cell Engineering, Johns Hopkins University, Baltimore, USA., Bressler J; Hugo Moser Institute at the Kennedy Krieger, Johns Hopkins University, Baltimore, USA., Christian KM; Department of Neurology, Johns Hopkins University, Baltimore, USA.; Institute for Cell Engineering, Johns Hopkins University, Baltimore, USA., Harris G; Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore, USA., Ming GL; Department of Neurology, Johns Hopkins University, Baltimore, USA.; Institute for Cell Engineering, Johns Hopkins University, Baltimore, USA.; The Solomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, USA., Berlinicke CJ; Wilmer Eye Institute, Johns Hopkins University, Baltimore, USA., Kyro K; US Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, USA., Song H; Department of Neurology, Johns Hopkins University, Baltimore, USA.; Institute for Cell Engineering, Johns Hopkins University, Baltimore, USA.; The Solomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, USA., Pardo CA; Department of Neurology, Johns Hopkins University, Baltimore, USA.; Division of Neuroimmunology, Johns Hopkins University, Baltimore, USA., Hartung T; Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore, USA.; University of Konstanz, Konstanz, Germany., Hogberg HT; Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore, USA.

Publikováno v: ALTEX [ALTEX] 2017; Vol. 34 (3), pp. 362-376. Date of Electronic Publication: 2016 Nov 24.

Microphysiological systems: What it takes for community adoption.

Autor: Hargrove-Grimes, Passley, Low, Lucie A, Tagle, Danilo A

Publikováno v: Experimental Biology & Medicine; 6/15/2021, Vol. 246 Issue 12, p1435-1446, 12p

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone.

Autor: Harris, Georgina, Eschment, Melanie, Orozco, Sebastian Perez, McCaffery, J. Michael, Maclennan, Richard, Severin, Daniel, Leist, Marcel, Kleensang, Andre, Pamies, David, Maertens, Alexandra, Hogberg, Helena T., Freeman, Dana, Kirkwood, Alfredo, Hartung, Thomas, Smirnova, Lena

Publikováno v: Archives of Toxicology; Aug2018, Vol. 92 Issue 8, p2587-2606, 20p, 8 Graphs