Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.

Autor: Smith N; Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA., Dasgupta M; Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA., Wych DC; Computer, Computational, and Statistical Sciences Division, Los Alamos National Laboratory, Los Alamos, NM 875405, USA.; Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Dolamore C; Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA., Sierra RG; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA., Lisova S; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA., Marchany-Rivera D; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA., Cohen AE; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA., Boutet S; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA., Hunter MS; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA., Kupitz C; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA., Poitevin F; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA., Moss FR 3rd; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA., Mittan-Moreau DW; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Brewster AS; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Sauter NK; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Young ID; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Wolff AM; Department of Chemistry and Biochemistry, University of California, Merced, CA 95340, USA., Tiwari VK; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA., Kumar N; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA., Berkowitz DB; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA., Hadt RG; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Thompson MC; Department of Chemistry and Biochemistry, University of California, Merced, CA 95340, USA., Follmer AH; Department of Chemistry, University of California-Irvine, Irvine, CA 92697, USA., Wall ME; Computer, Computational, and Statistical Sciences Division, Los Alamos National Laboratory, Los Alamos, NM 875405, USA., Wilson MA; Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.

Publikováno v: Science advances [Sci Adv] 2024 Mar 29; Vol. 10 (13), pp. eadk7201. Date of Electronic Publication: 2024 Mar 27.

Information-Rich, Dual-Function ¹³ C/ ² H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme "Partitioning Fingerprint" and Reveals Disparate Chemotypes for hSR Inhibition.

Autor: Ramos de Dios SM; Department of Chemistry, University of Nebraska, Lincoln, Lincoln, Nebraska 68588, United States., Hass JL; Department of Chemistry, University of Nebraska, Lincoln, Lincoln, Nebraska 68588, United States., Graham DL; Department of Chemistry, University of Nebraska, Lincoln, Lincoln, Nebraska 68588, United States., Kumar N; Department of Chemistry, University of Nebraska, Lincoln, Lincoln, Nebraska 68588, United States., Antony AE; Department of Chemistry, University of Nebraska, Lincoln, Lincoln, Nebraska 68588, United States., Morton MD; Department of Chemistry, University of Nebraska, Lincoln, Lincoln, Nebraska 68588, United States., Berkowitz DB; Department of Chemistry, University of Nebraska, Lincoln, Lincoln, Nebraska 68588, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 Feb 08; Vol. 145 (5), pp. 3158-3174. Date of Electronic Publication: 2023 Jan 25.

Biomacromolecule-Assisted Screening for Reaction Discovery and Catalyst Optimization.

Autor: Ramos De Dios SM; Biogen, Durham, North Carolina 27709, United States., Tiwari VK; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States., McCune CD; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States., Dhokale RA; Higuchi Biosciences Center, University of Kansas, Lawrence, Kansas 66047, United States., Berkowitz DB; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.

Publikováno v: Chemical reviews [Chem Rev] 2022 Aug 24; Vol. 122 (16), pp. 13800-13880. Date of Electronic Publication: 2022 Jul 29.

Genomic variants associated with type 2 diabetes mellitus among Filipinos.

Autor: C. Cutiongco-de la Paz, Eva Maria^1,2 (AUTHOR) eccutiongcodelapaz@up.edu.ph, Nevado Jr., Jose B.¹ (AUTHOR), Paz-Pacheco, Elizabeth T.³ (AUTHOR), Jasul Jr., Gabriel V.³ (AUTHOR), Aman, Aimee Yvonne Criselle L.¹ (AUTHOR), Francisco, Mark David G.³ (AUTHOR)

Publikováno v: PLoS ONE. 11/19/2024, Vol. 19 Issue 11, p1-17. 17p.

Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome.

Autor: Moore R; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, USA., Puniya BL; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, USA., Powers R; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, USA., Guda C; Department of Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE, USA., Bayles KW; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA., Berkowitz DB; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, USA., Helikar T; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, USA. thelikar2@unl.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Mar 10; Vol. 11 (1), pp. 5585. Date of Electronic Publication: 2021 Mar 10.