Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Berkley Gryder"'
Autor:
Deblina Banerjee, Sukriti Bagchi, Zhihui Liu, Hsien-Chao Chou, Man Xu, Ming Sun, Sara Aloisi, Zalman Vaksman, Sharon J. Diskin, Mark Zimmerman, Javed Khan, Berkley Gryder, Carol J. Thiele
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Temporal regulation of super-enhancer (SE) driven transcription factors (TFs) underlies normal developmental programs. Neuroblastoma (NB) arises from an inability of sympathoadrenal progenitors to exit a self-renewal program and terminally d
Externí odkaz:
https://doaj.org/article/e046b0fa15084801bf258b679fd00713
Autor:
Royce W. Zhou, Jia Xu, Tiphaine C. Martin, Alexis L. Zachem, John He, Sait Ozturk, Deniz Demircioglu, Ankita Bansal, Andrew P. Trotta, Bruno Giotti, Berkley Gryder, Yao Shen, Xuewei Wu, Saul Carcamo, Kaitlyn Bosch, Benjamin Hopkins, Alexander Tsankov, Randolph Steinhagen, Drew R. Jones, John Asara, Jerry E. Chipuk, Rachel Brody, Steven Itzkowitz, Iok In Christine Chio, Dan Hasson, Emily Bernstein, Ramon E. Parsons
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The changes in super-enhancer (SE) landscape of cancers are mainly attributed to cell-intrinsic genomic alterations. Here, the authors perform epigenomic profiling on primary colorectal cancers (CRCs) and their matched normal tissues and show that lo
Externí odkaz:
https://doaj.org/article/160f539e4f1344ce8856c7dd4c65e157
Autor:
Royce W. Zhou, Jia Xu, Tiphaine C. Martin, Alexis L. Zachem, John He, Sait Ozturk, Deniz Demircioglu, Ankita Bansal, Andrew P. Trotta, Bruno Giotti, Berkley Gryder, Yao Shen, Xuewei Wu, Saul Carcamo, Kaitlyn Bosch, Benjamin Hopkins, Alexander Tsankov, Randolph Steinhagen, Drew R. Jones, John Asara, Jerry E. Chipuk, Rachel Brody, Steven Itzkowitz, Iok In Christine Chio, Dan Hasson, Emily Bernstein, Ramon E. Parsons
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/9c2c6cb8439a47878da63f05bb8f178d
Autor:
Xiao Ling Li, Murugan Subramanian, Matthew F. Jones, Ritu Chaudhary, Deepak K. Singh, Xinying Zong, Berkley Gryder, Sivasish Sindri, Min Mo, Aaron Schetter, Xinyu Wen, Swetha Parvathaneni, Dickran Kazandjian, Lisa M. Jenkins, Wei Tang, Fathi Elloumi, Jennifer L. Martindale, Maite Huarte, Yuelin Zhu, Ana I. Robles, Susan M. Frier, Frank Rigo, Maggie Cam, Stefan Ambs, Sudha Sharma, Curtis C. Harris, Mary Dasso, Kannanganattu V. Prasanth, Ashish Lal
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2408-2423 (2017)
Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation results in elevated p53 levels to induce cell cycle arrest, apoptosis, and tumor suppression. Here, we report the suppression of basal p53 levels by a nuclear
Externí odkaz:
https://doaj.org/article/44875ca0858a47c68888951b9611cf2c
Autor:
Ina Chen, Lesley Mathews-Greiner, Dandan Li, Abisola Abisoye-Ogunniyan, Satyajit Ray, Yansong Bian, Vivek Shukla, Xiaohu Zhang, Raj Guha, Craig Thomas, Berkley Gryder, Athina Zacharia, Joal D. Beane, Sarangan Ravichandran, Marc Ferrer, Udo Rudloff
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-16 (2017)
Abstract Background Patients with hereditary diffuse gastric cancer (HDGC), a cancer predisposition syndrome associated with germline mutations of the CDH1 (E-cadherin) gene, have few effective treatment options. Despite marked differences in natural
Externí odkaz:
https://doaj.org/article/d6dcaf17bdb84036b90130567203e47c
Autor:
Elad Jacoby, Sang M. Nguyen, Thomas J. Fountaine, Kathryn Welp, Berkley Gryder, Haiying Qin, Yinmeng Yang, Christopher D. Chien, Alix E. Seif, Haiyan Lei, Young K. Song, Javed Khan, Daniel W. Lee, Crystal L. Mackall, Rebecca A. Gardner, Michael C. Jensen, Jack F. Shern, Terry J. Fry
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
CAR-T targeting CD19 have been successfully used in a variety of B-cell malignancies but patients may eventually relapse. Here, the authors show that CD19 CAR-T resistance in pre-B cell ALL can be due to the induction of a myeloid lineage switch thro
Externí odkaz:
https://doaj.org/article/97b2ab47d3724d76ba75fa902257a2ba
Autor:
Ritu Chaudhary, Berkley Gryder, Wendy S Woods, Murugan Subramanian, Matthew F Jones, Xiao Ling Li, Lisa M Jenkins, Svetlana A Shabalina, Min Mo, Mary Dasso, Yuan Yang, Lalage M Wakefield, Yuelin Zhu, Susan M Frier, Branden S Moriarity, Kannanganattu V Prasanth, Pablo Perez-Pinera, Ashish Lal
Publikováno v:
eLife, Vol 6 (2017)
Thousands of long noncoding RNAs (lncRNAs) have been discovered, yet the function of the vast majority remains unclear. Here, we show that a p53-regulated lncRNA which we named PINCR (p53-induced noncoding RNA), is induced ~100-fold after DNA damage
Externí odkaz:
https://doaj.org/article/0e4efcf121494f7b9aa2a822c1a3169e
Autor:
Inês M Tenente, Madeline N Hayes, Myron S Ignatius, Karin McCarthy, Marielle Yohe, Sivasish Sindiri, Berkley Gryder, Mariana L Oliveira, Ashwin Ramakrishnan, Qin Tang, Eleanor Y Chen, G Petur Nielsen, Javed Khan, David M Langenau
Publikováno v:
eLife, Vol 6 (2017)
Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely reflects the target cell o
Externí odkaz:
https://doaj.org/article/cdb12781b75a4561a7a9ff10ad882bb8
Autor:
Devin Neu, Stevephen Hung, Cynthia F. Bartels, Zachary J. Faber, Katreya Lovrenert, W. Dean Pontius, Laura Morgan, Maharshi Chakraborty, Will Liao, Diana Chin, Ellen S. Hong, Jeremy Gray, Victor Moreno, Matthew Kalady, Ulrike Peters, Berkley Gryder, Richard C. Sallari, Peter C. Scacheri
Transposable elements become increasingly active in both cancerous and aging cells, driven by loss of DNA methylation as cells divide. Here we leverage the epigenomes of colon cancers with matched adjacent tissue, in addition to non-cancerous normals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2b7b28d2b35a1559efaa7c0ad5fa31b
https://doi.org/10.1101/2023.05.17.541189
https://doi.org/10.1101/2023.05.17.541189
Autor:
Javed Khan, Jimmy C. Lin, Rosandra N. Kaplan, Melinda S. Merchant, Brigitte C. Widemann, Toby N. Trahair, James C. League-Pascual, Kip R. Hartman, Markku Miettinen, Thomas C. Badgett, Xinyu Wen, Nityashree Shivaprasad, Kathleen A. Calzone, Shile Zhang, Berkley Gryder, Marielle E. Yohe, Young K. Song, Jun S. Wei, Jack F. Shern, Sivasish Sindiri, Rajesh Patidar, Andrew S. Brohl, Wendy Chang
Using transcriptome data for expression profiling of tumors. Heatmap of transcriptome data allowing for expression profiling and clustering of diagnoses based on the 2000 most highly differentially expressed genes in comparison to the other cohort sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33de5395179da068bf9200ed85636a88
https://doi.org/10.1158/1078-0432.22455474.v1
https://doi.org/10.1158/1078-0432.22455474.v1