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AMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism.

Autor: Brombacher EC; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands., Patente TA; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands., van der Ham AJ; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands., Moll TJA; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands., Otto F; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands., Verheijen FWM; Department Biomolecular Health Sciences, Utrecht University, Utrecht, Netherlands., Zaal EA; Department Biomolecular Health Sciences, Utrecht University, Utrecht, Netherlands., de Ru AH; Center for Proteomics and Metabolomics, Leiden University Medical Center , Leiden, Netherlands., Tjokrodirijo RTN; Center for Proteomics and Metabolomics, Leiden University Medical Center , Leiden, Netherlands., Berkers CR; Department Biomolecular Health Sciences, Utrecht University, Utrecht, Netherlands., van Veelen PA; Center for Proteomics and Metabolomics, Leiden University Medical Center , Leiden, Netherlands., Guigas B; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands., Everts B; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands.

Publikováno v: The Journal of cell biology [J Cell Biol] 2024 Oct 07; Vol. 223 (10). Date of Electronic Publication: 2024 Aug 08.

Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis.

Autor: de Kivit S; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands. Electronic address: s.de_kivit@lumc.nl., Mensink M; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Kostidis S; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Derks RJE; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Zaal EA; Division of Cell Biology, Metabolism, and Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, the Netherlands., Heijink M; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Verleng LJ; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., de Vries E; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Schrama E; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Blomberg N; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Berkers CR; Division of Cell Biology, Metabolism, and Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, the Netherlands., Giera M; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Borst J; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands. Electronic address: j.g.borst@lumc.nl.

Publikováno v: Cell reports [Cell Rep] 2024 Sep 24; Vol. 43 (9), pp. 114681. Date of Electronic Publication: 2024 Aug 23.

Oleic acid enhances proliferation and calcium mobilization of CD3/CD28 activated CD4 ⁺ T cells through incorporation into membrane lipids.

Autor: von Hegedus JH; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., de Jong AJ; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Hoekstra AT; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands., Spronsen E; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Zhu W; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Cabukusta B; Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands., Kwekkeboom JC; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Heijink M; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands., Bos E; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Berkers CR; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands., Giera MA; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands., Toes REM; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Ioan-Facsinay A; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: European journal of immunology [Eur J Immunol] 2024 Sep; Vol. 54 (9), pp. e2350685. Date of Electronic Publication: 2024 Jun 18.

P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance.

Autor: Jiang X; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg, Germany.; Department of Thoracic Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, China., Baig AH; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg, Germany., Palazzo G; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg, Germany.; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany., Del Pizzo R; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg, Germany.; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany., Bortecen T; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany.; Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Groessl S; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany.; Division of Cell Signaling and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany., Zaal EA; Division of Cell Biology, Metabolism and Cancer, Department Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, CL, Utrecht, The Netherlands., Amaya Ramirez CC; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg, Germany., Kowar A; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg, Germany.; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany., Aviles-Huerta D; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg, Germany.; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany., Berkers CR; Division of Cell Biology, Metabolism and Cancer, Department Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, CL, Utrecht, The Netherlands., Palm W; Division of Cell Signaling and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany., Tschaharganeh D; Cell Plasticity and Epigenetic Remodeling, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Krijgsveld J; Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Faculty, University of Heidelberg, Heidelberg, Germany., Loayza-Puch F; Translational Control and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg, Germany. f.loayza-puch@dkfz-heidelberg.de.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 28; Vol. 15 (1), pp. 7458. Date of Electronic Publication: 2024 Aug 28.