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Akademický článek

Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation.

Autor: Berke JM; Infectious Diseases Discovery, Infectious Diseases and Vaccines, Janssen Research and Development, Turnhoutseweg, Beerse, Belgium., Tan Y; Infectious Diseases Discovery, Janssen Research and Development, Jinchuang Mansion, Pudong, Shanghai, China., Sauviller S; Infectious Diseases Discovery, Infectious Diseases and Vaccines, Janssen Research and Development, Turnhoutseweg, Beerse, Belgium., Wu D-t; Infectious Diseases Discovery, Janssen Research and Development, Jinchuang Mansion, Pudong, Shanghai, China., Zhang K; Infectious Diseases Discovery, Janssen Research and Development, Jinchuang Mansion, Pudong, Shanghai, China., Conceição-Neto N; Infectious Diseases Discovery, Infectious Diseases and Vaccines, Janssen Research and Development, Turnhoutseweg, Beerse, Belgium., Blázquez Moreno A; Infectious Diseases Biomarkers, Infectious Diseases and Vaccines, Janssen Research and Development, Turnhoutseweg, Beerse, Belgium., Kong D; Infectious Diseases Discovery, Janssen Research and Development, Jinchuang Mansion, Pudong, Shanghai, China., Kukolj G; Infectious Diseases Discovery, Janssen Research and Development, Brisbane, California, USA., Li C; Infectious Diseases Discovery, Janssen Research and Development, Brisbane, California, USA., Zhu R; Infectious Diseases Discovery, Janssen Research and Development, Jinchuang Mansion, Pudong, Shanghai, China., Nájera I; Infectious Diseases Discovery, Janssen Research and Development, Brisbane, California, USA., Pauwels F; Infectious Diseases Discovery, Infectious Diseases and Vaccines, Janssen Research and Development, Turnhoutseweg, Beerse, Belgium.

Publikováno v: Journal of virology [J Virol] 2024 Mar 19; Vol. 98 (3), pp. e0150223. Date of Electronic Publication: 2024 Feb 05.

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Akademický článek

Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR.

Autor: Lecoq L; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Brigandat L; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Huber R; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Fogeron ML; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Wang S; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Dujardin M; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Briday M; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Wiegand T; Physical Chemistry, ETH Zurich, 8093, Zurich, Switzerland.; Max-Planck-Institute for Chemical Energy Conversion, Stiftstr. 34-36, 45470, Mülheim an der Ruhr, Germany.; Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074, Aachen, Germany., Callon M; Physical Chemistry, ETH Zurich, 8093, Zurich, Switzerland., Malär A; Physical Chemistry, ETH Zurich, 8093, Zurich, Switzerland., Durantel D; Centre de recherche en cancérologie de Lyon (CRCL), UMR 5286, Centre Léon Bérard, 69373, Lyon, France., Burdette D; Gilead Sciences, Foster, CA, USA., Berke JM; Janssen Pharmaceutica N.V, Beerse, Belgium., Meier BH; Physical Chemistry, ETH Zurich, 8093, Zurich, Switzerland. beme@ethz.ch., Nassal M; Dept. of Medicine II/Molecular Biology, University of Freiburg, Freiburg, Germany. michael.nassal@uniklinik-freiburg.de., Böckmann A; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France. a.bockmann@ibcp.fr.

Publikováno v: Nature communications [Nat Commun] 2023 Jan 28; Vol. 14 (1), pp. 471. Date of Electronic Publication: 2023 Jan 28.

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Akademický článek

Development of a cellular high-content, immunofluorescent HBV core assay to identify novel capsid assembly modulators that induce the formation of aberrant HBV core structures.

Autor: Sauviller S; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Vergauwen K; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Jaensch S; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Gustin E; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Peeters D; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Vermeulen P; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Wuyts D; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Vandyck K; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Pauwels F; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Berke JM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium. Electronic address: jberke@its.jnj.com.

Publikováno v: Journal of virological methods [J Virol Methods] 2021 Jul; Vol. 293, pp. 114150. Date of Electronic Publication: 2021 Apr 08.

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Akademický článek

Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy.

Autor: Verbinnen T; Janssen Research & Development, Beerse, Belgium., Hodari M; Janssen Research & Development, Beerse, Belgium., Talloen W; Janssen Research & Development, Beerse, Belgium., Berke JM; Janssen Research & Development, Beerse, Belgium., Blue D; Janssen Biopharma Inc, South San Francisco, CA, USA., Yogaratnam J; Janssen Biopharma Inc, South San Francisco, CA, USA., Vandenbossche J; Janssen Research & Development, Beerse, Belgium., Shukla U; Janssen Pharmaceuticals Research & Development, Titusville, FL, USA., De Meyer S; Janssen Research & Development, Beerse, Belgium., Lenz O; Janssen Research & Development, Beerse, Belgium.

Publikováno v: Journal of viral hepatitis [J Viral Hepat] 2020 Nov; Vol. 27 (11), pp. 1127-1137. Date of Electronic Publication: 2020 Jul 20.

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Akademický článek

Anti-HBV activity of the HBV capsid assembly modulator JNJ-56136379 across full-length genotype A-H clinical isolates and core site-directed mutants in vitro.

Autor: Verbinnen T; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Tan Y; Janssen China Research & Development Center, 5F North Building #1 Jinchuang Mansion, 4560 Jinke Road, Shanghai 201210, China., Wang G; Janssen China Research & Development Center, 5F North Building #1 Jinchuang Mansion, 4560 Jinke Road, Shanghai 201210, China., Dehertogh P; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Vergauwen K; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Neefs JM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Jacoby E; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Lenz O; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Berke JM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2020 Sep 01; Vol. 75 (9), pp. 2526-2534.

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Akademický článek

Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379.

Autor: Berke JM; Janssen Research and Development, Beerse, Belgium jberke@its.jnj.com., Dehertogh P; Janssen Research and Development, Beerse, Belgium., Vergauwen K; Janssen Research and Development, Beerse, Belgium., Mostmans W; Janssen Research and Development, Beerse, Belgium., Vandyck K; Janssen Research and Development, Beerse, Belgium., Raboisson P; Janssen Research and Development, Beerse, Belgium., Pauwels F; Janssen Research and Development, Beerse, Belgium.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Apr 21; Vol. 64 (5). Date of Electronic Publication: 2020 Apr 21 (Print Publication: 2020).

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