Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Beril Tutuncuoglu"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
As assembling 60S subunits transit from the nucleolus to the nucleoplasm, they undergo significant changes in protein composition and structure. Here, the authors provide a structural view of interconnected events during the middle steps of assembly
Externí odkaz:
https://doaj.org/article/611c8aa58da84f4380a6473f6b8702a1
Autor:
Beril Tutuncuoglu, Nevan J. Krogan
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with B
Externí odkaz:
https://doaj.org/article/3c032603170d412c88835f86130dc306
Autor:
Nevan J. Krogan, David E. Gordon, Manon Eckhardt, Mehdi Bouhaddou, Jyoti Batra, Merve Cakir, Beril Tutuncuoglu
Cancer drugs targeting the identified virus-host protein-protein interactions of SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11da17320ff51cdffc7c6da9c14dc8ec
https://doi.org/10.1158/2159-8290.22534991
https://doi.org/10.1158/2159-8290.22534991
Autor:
Nevan J. Krogan, David E. Gordon, Manon Eckhardt, Mehdi Bouhaddou, Jyoti Batra, Merve Cakir, Beril Tutuncuoglu
Summary:The mapping of SARS-CoV-2 human protein–protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we highlight several oncogenic pathways identified at the host–virus interface of SARS-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9df4bb7a6c1f8ee7aedfca50016bbec1
https://doi.org/10.1158/2159-8290.c.6547727.v1
https://doi.org/10.1158/2159-8290.c.6547727.v1
Autor:
Shan Wu, Beril Tutuncuoglu, John L. Woolford, Ning Gao, Daniel H. Wilson, Jelena Micic, Yu Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
The protein composition and structure of assembling 60S ribosomal subunits undergo numerous changes as pre-ribosomes transition from the nucleolus to the nucleoplasm. This includes stable anchoring of the Rpf2 subcomplex containing 5S rRNA, rpL5, rpL
Autor:
Min-Kyu Kim, Jing Chen, Fan Zheng, Keiichiro Ono, Sophie Liu, Beril Tutuncuoglu, John J. Lee, Rudolf T. Pillich, Brent M. Kuenzi, Danielle L. Swaney, Jason F. Kreisberg, J. Silvio Gutkind, Erica Silva, Nicholas Wilson, Katherine Licon, Kari A. Herrington, Stephanie I. Fraley, Nevan J. Krogan, Dexter Pratt, Marcus R. Kelly, Christopher Churas, Michael Chen, Kai Tao, Jisoo Park, Xiaolin Nan, Dana J. Ramms, Anton Kratz, Trey Ideker, Marissa L. Heintschel, Michael Ku Yu, Helene Foussard, Devin Patel
Publikováno v:
Science (New York, N.Y.), vol 374, iss 6563
Science
Science
Mapping protein interactions driving cancer Cancer is a genetic disease, and much cancer research is focused on identifying carcinogenic mutations and determining how they relate to disease progression. Three papers demonstrate how mutations are proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bdd61e6a00d9bd25a0a7555abffde9
https://escholarship.org/uc/item/9839w2n4
https://escholarship.org/uc/item/9839w2n4
Autor:
Danielle L. Swaney, Kuei Ho Chen, Alan Ashworth, Morgan E. Diolaiti, Trey Ideker, Fan Zheng, Bing Xia, Kari A. Herrington, Beril Tutuncuoglu, Michael J. McGregor, John D. Gordan, Min-Kyu Kim, Mehdi Bouhaddou, Denise P. Muñoz, Denise M. Wolf, Erica Stevenson, Nevan J. Krogan, Margaret Soucheray, Tzeh Keong Foo, Patrick O’Leary, Ajda Rojc, Maya Modak, Kyumin Kim, Laura van 't Veer, Jean-Philippe Coppe, Jason F. Kreisberg, Jisoo Park, Dominique C. Mitchell
Publikováno v:
Science
Science (New York, N.Y.), vol 374, iss 6563
Science (New York, N.Y.), vol 374, iss 6563
Mapping protein interactions driving cancer Cancer is a genetic disease, and much cancer research is focused on identifying carcinogenic mutations and determining how they relate to disease progression. Three papers demonstrate how mutations are proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375ba5ac99a6a028e92c535730897988
https://europepmc.org/articles/PMC9040556/
https://europepmc.org/articles/PMC9040556/
Autor:
Merve Cakir, David E. Gordon, Nevan J. Krogan, Manon Eckhardt, Jyoti Batra, Beril Tutuncuoglu, Mehdi Bouhaddou
Publikováno v:
Cancer discovery, vol 10, iss 7
Cancer Discovery
Cancer Discovery
Summary: The mapping of SARS-CoV-2 human protein–protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we highlight several oncogenic pathways identified at the host–virus interface of SARS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59d720a6aecd6d54eca1aaf8ed15d75
https://escholarship.org/uc/item/5230916c
https://escholarship.org/uc/item/5230916c
Autor:
Yiming Cai, Maya Modak, Sebastian Weigang, Emmie de Wit, Jean K. Lim, Alistair Dunham, Benjamin J. Polacco, Qiongyu Li, Svenja Ulferts, Gwendolyn M. Jang, Aurelien Dugourd, David E. Gordon, Jeffrey Z. Guo, Kirsten Obernier, Sophia Bouhaddou, Elizabeth R. Fischer, Anna Gaulton, Jason C.J. Chang, Bjoern Meyer, Diego Quintero, Julian Knerr, Trupti Patil, Emma J. Manners, Michael C. O’Neal, Monita Muralidharan, Joseph Hiatt, Ajda Rojc, James E. Melnyk, Tanja Kortemme, Benjamin R. tenOever, Thomas Vallet, Rémy Robinot, Cassandra Koh, Benjamin E. Nilsson-Payant, Ruth Hüttenhain, Saker Klippsten, Alicia L. Richards, Eloy Felix, Brian K. Shoichet, Beril Tutuncuoglu, Danielle L. Swaney, Veronica V. Rezelj, Jeffery R. Johnson, Margaret Soucheray, Marisa Goff, R. Dyche Mullins, Kris M. White, Erica Stevenson, Jyoti Batra, Christopher J.P. Mathy, Yuan Zhou, Minkyu Kim, Marco Vignuzzi, Claudia Hernandez-Armenta, Kevan M. Shokat, Julio Saez-Rodriguez, Jacqueline M. Fabius, Timothy McBride, Adolfo García-Sastre, Quang Dinh Tran, Alexandra Hardy, Elena Moreno, Alberto Valdeolivas, Mehdi Bouhaddou, Andrew R. Leach, Melanie Ott, Georg Kochs, Pedro Beltrao, Jiewei Xu, Robyn M. Kaake, Merve Cakir, Ying Shi, Nevan J. Krogan, Lisa Miorin, Danish Memon, David J. Broadhurst, Miguel Correa Marrero, Robert Grosse
Publikováno v:
Cell
Cell, vol 182, iss 3
Cell, Elsevier, 2020, 182, pp.685-712.e19. ⟨10.1016/j.cell.2020.06.034⟩
Cell, 2020, 182 (3), pp.685-712.e19. ⟨10.1016/j.cell.2020.06.034⟩
Cell, vol 182, iss 3
Cell, Elsevier, 2020, 182, pp.685-712.e19. ⟨10.1016/j.cell.2020.06.034⟩
Cell, 2020, 182 (3), pp.685-712.e19. ⟨10.1016/j.cell.2020.06.034⟩
Summary The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to
Autor:
Pedro Beltrao, Phillip P. Sharp, Nevan J. Krogan, Sabrina J. Fletcher, Saker Klippsten, Trey Ideker, Melanie Ott, Bryan L. Roth, Xi Liu, Devin A. Cavero, Djoshkun Shengjuler, Christopher J.P. Mathy, Jason C.J. Chang, Theodore L. Roth, Hannes Braberg, Claudia Hernandez-Armenta, Lisa Miorin, Jyoti Batra, Shizhong Dai, Maliheh Safari, Brian K. Shoichet, Danish Memon, Tia A. Tummino, Marco Vignuzzi, Mark von Zastrow, Manon Eckhardt, Alan D. Frankel, Qiongyu Li, Tanja Kortemme, Nicole A. Wenzell, Zun Zar Chi Naing, Ferdinand Roesch, Nastaran Sadat Savar, Mathieu Hubert, Xi Ping Huang, Elena Moreno, Danica Galonić Fujimori, Jeffrey Z. Guo, Natalia Jura, Kirsten Obernier, Kliment A. Verba, Harmit S. Malik, Hao-Yuan Wang, Michael McGregor, Melanie J. Bennett, Julia Noack, Gwendolyn M. Jang, Paige Haas, Alice Mac Kain, Daniel J. Saltzberg, Mehdi Bouhaddou, Ziyang Zhang, Yongfeng Liu, Inigo Barrio-Hernandez, Yiming Cai, Kris M. White, Kelsey M. Haas, Maya Modak, Stephanie A. Wankowicz, Raphael Trenker, Kevan M. Shokat, Fatima S. Ugur, Shiming Peng, Sai J. Ganesan, Shaeri Mukherjee, Yuan Zhou, Minkyu Kim, John D. Gross, Jack Taunton, Alicia L. Richards, John S. Chorba, Margaret Soucheray, Danielle L. Swaney, Benjamin J. Polacco, Alan Ashworth, Wenqi Shen, Adolfo García-Sastre, Merve Cakir, Ujjwal Rathore, Kala Bharath Pilla, Michael C. O’Neal, Ying Shi, Kevin Lou, Cassandra Koh, Stephen N. Floor, Davide Ruggero, Ilsa T Kirby, Srivats Venkataramanan, Ruth Hüttenhain, Olivier Schwartz, Beril Tutuncuoglu, Christophe d'Enfert, Jose Liboy-Lugo, David A. Agard, Charles S. Craik, Veronica V. Rezelj, Tina Perica, Matthew P. Jacobson, Lorenzo Calviello, Eric Verdin, Yizhu Lin, Jiankun Lyu, Jiewei Xu, Joseph Hiatt, Andrej Sali, Oren S. Rosenberg, Markus Bohn, David E. Gordon, James S. Fraser, Sara Brin Rosenthal, Duygu Kuzuoğlu-Öztürk, Robyn M. Kaake, Jacqueline M. Fabius, Matthew J. O’Meara, Quang Dinh Tran, Advait Subramanian, Thomas Vallet, Bjoern Meyer, James E. Melnyk, Robert M. Stroud, Helene Foussard, Rakesh Ramachandran, David J. Broadhurst, Janet M. Young, Michael Emerman
Publikováno v:
Nature
Schizophrenia Research
Schizophrenia Research
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to the death of more than 160,000 individ