Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Beric R. Henderson"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 19, Iss , Pp - (2019)
Beta-catenin is well-known as a key effector of Wnt signalling and aberrant expression is associated with several human cancers. Stabilisation of and atypical subcellular localisation of beta-catenin, regulated in part through specific protein-protei
Externí odkaz:
https://doaj.org/article/5da950a5f6e6443fa355400a975af773
Autor:
Beric R. Henderson
Publikováno v:
Scientifica, Vol 2012 (2012)
Inherited mutations in the BRCA1 gene predispose to a higher risk of breast/ovarian cancer. The BRCA1 tumor suppressor is a 1863 amino acid protein with multiple protein interaction domains that facilitate its roles in regulating DNA repair and maint
Externí odkaz:
https://doaj.org/article/c86ac2e94eed467b867876806c8c4bb5
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150484 (2016)
Activation of the wnt signaling pathway is a major cause of colon cancer development. Tankyrase inhibitors (TNKSi) have recently been developed to block the wnt pathway by increasing axin levels to promote degradation of the wnt-regulator β-catenin.
Externí odkaz:
https://doaj.org/article/28c5ed543ba342af96106c7672df9454
Publikováno v:
Cancer Letters. 381:149-155
We previously showed that BARD1 is a shuttling protein with pro-apoptotic activity in MCF-7 breast cancer cells. BARD1 is expressed as splice variant isoforms in breast cancer. Here we characterized YFP-tagged BARD1 splice variants (beta, omega, phi,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e5b9779375058c35e6a729a635cafd
https://doi.org/10.1016/j.canlet.2016.07.034
https://doi.org/10.1016/j.canlet.2016.07.034
Autor:
Kate M. Mills, Beric R. Henderson, Cara Jamieson, Jade K. Forwood, Crystal Semaan, Christina Lui, Manisha Sharma, Mark P. Molloy
Publikováno v:
Experimental Cell Research. 341:196-206
Beta-catenin plays a key role in transducing Wnt signals from the plasma membrane to the nucleus. Here we characterize an unusual subcellular distribution of beta-catenin in MCF-7 breast cancer cells, wherein beta-catenin localizes to the cytoplasm a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbcadb5f22951b7ae4e04ad921e4b60e
https://doi.org/10.1016/j.yexcr.2016.01.020
https://doi.org/10.1016/j.yexcr.2016.01.020
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 70:39-47
The adenomatous polyposis coli (APC) tumor suppressor is multi-functional. APC is known to localize at the centrosome, and in mitotic cells contributes to formation of the mitotic spindle. To test whether APC contributes to nascent microtubule (MT) g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ed72732559fe5d0a7e72cb31a74733
https://doi.org/10.1016/j.biocel.2015.10.028
https://doi.org/10.1016/j.biocel.2015.10.028
Autor:
David I. Yule, Russell R. Snyder, Damian B. van Rossum, Serena C. Hedgepeth, Larry E. Wagner, Kirsty M. Brodie, Ana M. Rodriguez, M. Iveth Garcia, Sree V. Chintapalli, Beric R. Henderson, Gary D.V. Hankins, Darren Boehning
Publikováno v:
Journal of Biological Chemistry. 290:7304-7313
The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitously expressed endoplasmic reticulum (ER)-resident calcium channel. Calcium release mediated by IP3Rs influences many signaling pathways, including those regulating apoptosis. IP3R activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923dfe908a636782f768d0dc88cae697
https://doi.org/10.1074/jbc.m114.611186
https://doi.org/10.1074/jbc.m114.611186
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 57:27-34
Rapid assembly of DNA damage response (DDR) proteins at nuclear "repair" foci is a hallmark response of ionizing radiation (IR)-treated cells. The ubiquitin E3 ligases RNF8 and RNF168 are critical for foci formation, and here we aim to determine thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c54b4e808246894040ad11e91712ca
https://doi.org/10.1016/j.biocel.2014.09.027
https://doi.org/10.1016/j.biocel.2014.09.027
Publikováno v:
Oncogene. 34:485-495
High expression of Ankyrin Repeat Domain 1 (ANKRD1) in ovarian carcinoma is associated with poor survival, and in ovarian cancer cell lines is associated with platinum resistance. Importantly, decreasing ANKRD1 expression using siRNA increases cispla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc98d33c2b9638d1df7793f23153ea09
https://doi.org/10.1038/onc.2013.566
https://doi.org/10.1038/onc.2013.566
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 19, Iss, Pp-(2019)
Biochemistry and Biophysics Reports, Vol 19, Iss, Pp-(2019)
Beta-catenin is well-known as a key effector of Wnt signalling and aberrant expression is associated with several human cancers. Stabilisation of and atypical subcellular localisation of beta-catenin, regulated in part through specific protein-protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0969c5f1f9803a13ae379eeafbacb319
https://doi.org/10.1016/j.bbrep.2019.100662
https://doi.org/10.1016/j.bbrep.2019.100662