Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Berhane M. Hagos"'
Autor:
Ozlen Balcioglu, Brooke L. Gates, David W. Freeman, Berhane M. Hagos, Elnaz Mirzaei Mehrabad, David Ayala-Talavera, Benjamin T. Spike
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Cell state control is crucial for normal tissue development and cancer cell mimicry of stem/progenitor states, contributing to tumor heterogeneity, therapy resistance, and progression. Here, we demonstrate that the cell surface glycoprotein
Externí odkaz:
https://doaj.org/article/d5c5ca99a1c0441b847786a473f5db05
Autor:
Ozlen Balcioglu, Richard E. Heinz, David W. Freeman, Brooke L. Gates, Berhane M. Hagos, Evan Booker, Elnaz Mirzaei Mehrabad, Hyrum T. Diesen, Kishan Bhakta, Supraja Ranganathan, Masami Kachi, Mathias Leblanc, Peter C. Gray, Benjamin T. Spike
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-14 (2020)
Abstract Background CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia
Externí odkaz:
https://doaj.org/article/c3087deb5d704acbbb79917f2e2e47ce
Autor:
Rajshekhar R. Giraddi, Chi-Yeh Chung, Richard E. Heinz, Ozlen Balcioglu, Mark Novotny, Christy L. Trejo, Christopher Dravis, Berhane M. Hagos, Elnaz Mirzaei Mehrabad, Luo Wei Rodewald, Jae Y. Hwang, Cheng Fan, Roger Lasken, Katherine E. Varley, Charles M. Perou, Geoffrey M. Wahl, Benjamin T. Spike
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
Summary: The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We ad
Externí odkaz:
https://doaj.org/article/38eeb434d83440d7b7cd474042626a72
Autor:
Ozlen Balcioglu, Brooke L. Gates, David W. Freeman, Berhane M. Hagos, Elnaz Mirzaei Mehrabad, David Ayala-Talavera, Benjamin T. Spike
Breast cancers are categorized into subtypes with distinctive therapeutic vulnerabilities based on expression of clinically targetable receptors and other genes that mimic cell types of the normal gland. Here, we tested the role of the plasma membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faa4b6a05b256ba2d587114b29ebfe43
https://doi.org/10.1101/2023.05.10.540211
https://doi.org/10.1101/2023.05.10.540211
Autor:
Xiaomeng Hou, J Hwang, Charles M. Perou, Bing Ren, Tannishtha Reya, Christy L. Trejo, Zhibo Ma, Christopher Dravis, Sebastian Preissl, Jaslem Herrera-Valdez, Benjamin T. Spike, Roger S. Lasken, Mark Novotny, Geoff Wahl, Elnaz Mirzaei Mehrabad, Berhane M. Hagos, NE Lytle, Ozlen Balcioglu, Olivier Poirion, KT Varley, Chi-Yeh Chung, Cheng Fan, Gidsela Luna, RT Giraddi, Richard E. Heinz
Publikováno v:
Cancer Research. 80:ES10-2
Parallels among embryonic development, stem cells, and cancer have long been recognized. We identified, isolated, and characterized stem cells that first become committed to a mammary fate during embryogenesis; we refer to these cells as fetal mammar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eea19019b08580e51d8685a3f9dde727
https://doi.org/10.1158/1538-7445.sabcs19-es10-2
https://doi.org/10.1158/1538-7445.sabcs19-es10-2
Publikováno v:
Cancer Research. 82:1531-1531
CD146 (Mcam; Muc18; s-endo; and gicerin) is an integral membrane glycoprotein originally identified in a human malignant melanoma, but mis-expressed in a wider variety of malignancies including breast cancer, where it has been implicated in controlli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26a87f2b15b90bf5079914059bff5034
https://doi.org/10.1158/1538-7445.am2022-1531
https://doi.org/10.1158/1538-7445.am2022-1531
Autor:
Berhane M. Hagos, Brooke L. Gates, David W. Freeman, Masami Kachi, Benjamin T. Spike, Kishan Bhakta, Elnaz Mirzaei Mehrabad, Hyrum T Diesen, Supraja Ranganathan, Mathias Leblanc, Ozlen Balcioglu, Evan Booker, Peter C. Gray, Richard E. Heinz
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-14 (2020)
Background CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia suggesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259a122931cac7e4953c13e3f9e16105
https://doi.org/10.1186/s13058-020-01361-z
https://doi.org/10.1186/s13058-020-01361-z
Autor:
Ozlen, Balcioglu, Richard E, Heinz, David W, Freeman, Brooke L, Gates, Berhane M, Hagos, Evan, Booker, Elnaz, Mirzaei Mehrabad, Hyrum T, Diesen, Kishan, Bhakta, Supraja, Ranganathan, Masami, Kachi, Mathias, Leblanc, Peter C, Gray, Benjamin T, Spike
Publikováno v:
Breast Cancer Research : BCR
Background CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia suggesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3335b4b1b36cdf76cfde38ec7c48d47
https://pubmed.ncbi.nlm.nih.gov/33187540
https://pubmed.ncbi.nlm.nih.gov/33187540
Autor:
Ozlen Balcioglu, Heinz, Richard E., Freeman, David W., Gates, Brooke L., Berhane M. Hagos, Booker, Evan, Elnaz Mirzaei Mehrabad, Hyrum T. Diesen, Bhakta, Kishan, Supraja Ranganathan, Kachi, Masami, Leblanc, Mathias, Gray, Peter C., Spike, Benjamin T.
Additional file 1: Supplemental Fig. 1. A) Schematic of a lentiviral expression vector (S14) with fluorescent luminescent markers and doxycycline-inducible ALK4L75A-Fc. (B,C) Western blot demonstrating doxycycline-dependent expression of FLAG-tagged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58121b5647c24434afcc30fadec46b43
Autor:
Christopher Dravis, Chi-Yeh Chung, Cheng Fan, Rajshekhar R. Giraddi, Mark Novotny, Benjamin T. Spike, Elnaz Mirzaei Mehrabad, Berhane M. Hagos, Ozlen Balcioglu, Roger S. Lasken, Katherine E. Varley, Richard E. Heinz, Christy L. Trejo, Luo Wei Rodewald, Charles M. Perou, Jae Y. Hwang, Geoffrey M. Wahl
Publikováno v:
Cell reports
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
SUMMARY The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf69ec6d2a34e3038c5461594a6188d1
https://pubmed.ncbi.nlm.nih.gov/30089273
https://pubmed.ncbi.nlm.nih.gov/30089273