Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Berhane Ghebrehiwet"'
Autor:
Berhane Ghebrehiwet, Michal Zaniewski, Audrey Fernandez, Mathew DiGiovanni, Tiana N. Reyes, Ping Ji, Anne G. Savitt, Jennie L. Williams, Markus A. Seeliger, Ellinor I. B. Peerschke
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Understanding at the molecular level of the cell biology of tumors has led to significant treatment advances in the past. Despite such advances however, development of therapy resistance and tumor recurrence are still unresolved major challenges. Thi
Externí odkaz:
https://doaj.org/article/9414afff38834c27959bcaf27d0e7a86
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
Anaphylaxis is a potentially life-threatening multi-system allergic reaction to a biological trigger resulting in the release of potent inflammatory mediators from mast cells and basophils and causing symptoms in at least two organ systems that gener
Externí odkaz:
https://doaj.org/article/5b816c69547f4f77a9e26d65ceb4782f
Autor:
Andrea Balduit, Romana Vidergar, Paola Zacchi, Alessandro Mangogna, Chiara Agostinis, Micaela Grandolfo, Cristina Bottin, Francesco Salton, Paola Confalonieri, Andrea Rocca, Fabrizio Zanconati, Marco Confalonieri, Uday Kishore, Berhane Ghebrehiwet, Roberta Bulla
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Complement component C1q can act as a pro-tumorigenic factor in the tumor microenvironment (TME). The TME in malignant pleural mesothelioma (MPM) is rich in C1q and hyaluronic acid (HA), whose interaction enhances adhesion, migration and proliferatio
Externí odkaz:
https://doaj.org/article/9a6b8f6959214d31bd734cc79ae1ce91
Publikováno v:
Immunity, Inflammation and Disease, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract Background Vascular diseases are highly associated with inflammation and thrombosis. Elucidating links between these two processes may provide a clearer understanding of these diseases, allowing for the design of more effective treatments. T
Externí odkaz:
https://doaj.org/article/5bee9b5090324b00b2abbf82805c6dbc
Publikováno v:
Frontiers in Allergy, Vol 3 (2022)
Human high molecular weight kininogen (HK) is the substrate from which bradykinin is released as a result of activation of the plasma “contact” system, a cascade that includes the intrinsic coagulation pathway, and a fibrinolytic pathway leading
Externí odkaz:
https://doaj.org/article/b1aa9628f73b48829891e5d82ff78e5b
Autor:
Ying Zhang, Alexander J. Vontz, Ethan M. Kallenberger, Xin Xu, Nicoleta T. Ploscariu, Kasra X. Ramyar, Brandon L. Garcia, Berhane Ghebrehiwet, Brian V. Geisbrecht
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The protein gC1qR/C1qBP/HABP-1 plays an essential role in mitochondrial biogenesis, but becomes localized at the cellular surface in numerous pathophysiological states. When this occurs on endothelial cells, surface-exposed gC1qR activates the classi
Externí odkaz:
https://doaj.org/article/6319831229a44600b3b02d903db4aafb
Autor:
Julien Pothlichet, Annalisa Meola, Florence Bugault, Louise Jeammet, Anne G. Savitt, Berhane Ghebrehiwet, Lhousseine Touqui, Philippe Pouletty, Frédéric Fiore, Alain Sauvanet, Jacques Thèze
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The origin of the impaired CD4 T-cell response and immunodeficiency of HIV-infected patients is still only partially understood. We recently demonstrated that PLA2G1B phospholipase synergizes with the HIV gp41 envelope protein in HIV viremic plasma t
Externí odkaz:
https://doaj.org/article/b03bd2678ba64c0090485102c4cbf5f9
Autor:
Annika Sünderhauf, Maren Hicken, Heidi Schlichting, Kerstin Skibbe, Mohab Ragab, Annika Raschdorf, Misa Hirose, Holger Schäffler, Arne Bokemeyer, Dominik Bettenworth, Anne G. Savitt, Sven Perner, Saleh Ibrahim, Ellinor I. Peerschke, Berhane Ghebrehiwet, Stefanie Derer, Christian Sina
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 229-250 (2021)
Background & Aims: Cell differentiation in the colonic crypt is driven by a metabolic switch from glycolysis to mitochondrial oxidation. Mitochondrial and goblet cell dysfunction have been attributed to the pathology of ulcerative colitis (UC). We hy
Externí odkaz:
https://doaj.org/article/3c9778069d6f49cc96087014960b017d
Autor:
Anne G. Savitt, Samantha Manimala, Tiara White, Marina Fandaros, Wei Yin, Huiquan Duan, Xin Xu, Brian V. Geisbrecht, David A. Rubenstein, Allen P. Kaplan, Ellinor I. Peerschke, Berhane Ghebrehiwet
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Infection with SARS-CoV-2 triggers the simultaneous activation of innate inflammatory pathways including the complement system and the kallikrein-kinin system (KKS) generating in the process potent vasoactive peptides that contribute to severe acute
Externí odkaz:
https://doaj.org/article/6770e2f74e8948b8a62d2b8fa28fe7c4
Autor:
Annika Raschdorf, Annika Sünderhauf, Kerstin Skibbe, Berhane Ghebrehiwet, Ellinor I. Peerschke, Christian Sina, Stefanie Derer
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Rapid proliferation of cancer cells is enabled by favoring aerobic glycolysis over mitochondrial oxidative phosphorylation (OXPHOS). P32 (C1QBP/gC1qR) is essential for mitochondrial protein translation and thus indispensable for OXPHOS activity. It i
Externí odkaz:
https://doaj.org/article/c0e6039d992e48e782be4ae85be3b831