Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Berglund, U.W."'
Autor:
Zhao, Z., Gad, H., Benitez-Buelga, C., Sanjiv, K., Xiangwei, H., Kang, H., Feng, M., Berglund, U.W., Xia, Q., Helleday, T.
Hepatocellular carcinoma (HCC) patients suffer from few treatment options and poor survival rates. Here we report that endonuclease VIII-like protein 3 (NEIL3) is overexpressed in HCC and correlates with poor survival. All six HCC cell lines investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::1ea6e060eb3e5e25009a3dd51cfeec2c
https://eprints.whiterose.ac.uk/175701/7/4079.full.pdf
https://eprints.whiterose.ac.uk/175701/7/4079.full.pdf
Autor:
Oksvold, M.P., Berglund, U.W., Gad, H., Bai, B., Stokke, T., Rein, I.D., Pham, T., Sanjiv, K., Øy, G.F., Norum, J.H., Smeland, E.B., Myklebust, J.H., Helleday, T., Våtsveen, T.K.
Publikováno v:
Scientific Reports
Chemo-immunotherapy has improved survival in B-cell lymphoma patients, but refractory/relapsed diseases still represent a major challenge, urging for development of new therapeutics. Karonudib (TH1579) was developed to inhibit MTH1, an enzyme prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f4617cebf75488557fc63de218664007
Autor:
Scaletti, E.R., Vallin, K.S., Bräutigam, L., Sarno, A., Berglund, U.W., Helleday, T., Stenmark, P., Jemth, A.-S.
MutT homologue 1 (MTH1) removes oxidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome and thereby reduces genotoxicity. We previously reported that MTH1 is an efficient catalyst of O6-methyl-dGTP hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::8c209960d08b745a4e6a805e5b544f67
https://eprints.whiterose.ac.uk/159273/8/1-s2.0-S0021925817485735-main.pdf
https://eprints.whiterose.ac.uk/159273/8/1-s2.0-S0021925817485735-main.pdf
Background: Osteosarcoma (OS) is the most common primary malignant bone tumour. Unfortunately, no new treatments are approved and over the last 30 years the survival rate remains only 30% at 5 years for poor responders justifying an urgent need of ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::a0a1eeced7c2a105a5144d049fca09c1
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3077881
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3077881
Autor:
Moukengue, B., Brown, H.K., Charrier, C., Battaglia, S., Baud'huin, M., Quillard, T., Pham, T.M., Pateras, I.S., Gorgoulis, V.G., Helleday, T., Heymann, D., Berglund, U.W., Ory, B., Lamoureux, F.
Publikováno v:
EBioMedicine
EBioMedicine, 2020, 53, pp.102704. ⟨10.1016/j.ebiom.2020.102704⟩
EBioMedicine, Elsevier, 2020, 53, pp.102704. ⟨10.1016/j.ebiom.2020.102704⟩
EBioMedicine, Vol 53, Iss, Pp-(2020)
EBioMedicine, 2020, 53, pp.102704. ⟨10.1016/j.ebiom.2020.102704⟩
EBioMedicine, Elsevier, 2020, 53, pp.102704. ⟨10.1016/j.ebiom.2020.102704⟩
EBioMedicine, Vol 53, Iss, Pp-(2020)
Background: Osteosarcoma (OS) is the most common primary malignant bone tumour. Unfortunately, no new treatments are approved and over the last 30 years the survival rate remains only 30% at 5 years for poor responders justifying an urgent need of ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ed3180a13c71245eb176c5b269295c64
https://www.hal.inserm.fr/inserm-02529640
https://www.hal.inserm.fr/inserm-02529640
Autor:
Visnes, T., Benítez-Buelga, C., Cázares-Körner, A., Sanjiv, K., Hanna, B.M.F., Mortusewicz, O., Rajagopal, V., Albers, J.J., Hagey, D.W., Bekkhus, T., Eshtad, S., Baquero, J.M., Masuyer, G., Wallner, O., Müller, S., Pham, T., Göktürk, C., Rasti, A., Suman, S., Torres-Ruiz, R., Sarno, A., Wiita, E., Homan, E.J., Karsten, S., Marimuthu, K., Michel, M., Koolmeister, T., Scobie, M., Loseva, O., Almlöf, I., Unterlass, J.E., Pettke, A., Boström, J., Pandey, M., Gad, H., Herr, P., Jemth, A.-S., El Andaloussi, S., Kalderén, C., Rodriguez-Perales, S., Benítez, J., Krokan, H.E., Altun, M., Stenmark, P., Berglund, U.W., Helleday, T.
Publikováno v:
12234-12251
Nucleic Acids Research
Nucleic Acids Research
Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7fd8ce19837332df7926ecb7122c0d29
https://hdl.handle.net/11250/2788132
https://hdl.handle.net/11250/2788132
Background and Purpose: Small cell lung cancer (SCLC) is an aggressive disease with median survival of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::58e8336c963eb91ec312282ebaf7482a
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3021376
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3021376
Background: Previously, we showed cancer cells rely on the MTH1 protein to prevent incorporation of otherwise deadly oxidised nucleotides into DNA and we developed MTH1 inhibitors which selectively kill cancer cells. Recently, several new and potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::d4f7d594efd5579161a344606ec92d1b
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3100649
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3100649
Autor:
Das, I., Gad, H., Bräutigam, L., Pudelko, L., Tuominen, R., Höiom, V., Almlöf, I., Hansson, J., Helleday, T., Brage, S.E., Berglund, U.W.
Publikováno v:
In Annals of Oncology November 2019 30 Supplement 7:vii8-vii8
Akademický článek
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