Heterogeneity of treatment effect of higher dose dexamethasone by geographic region (Europe vs. India) in patients with COVID-19 and severe hypoxemia – a post hoc evaluation of the COVID STEROID 2 trial

Autor: Munch, Marie W., Myatra, Sheila N., Tirupakuzhi Vijayaraghavan, Bharath Kumar, Saseedharan, Sanjith, Benfield, Thomas, Wahlin, Rebecka R., Rasmussen, Bodil S., Andreasen, Anne Sofie, Poulsen, Lone M., Cioccari, Luca, Khan, Mohd S., Kapadia, Farhad, Divatia, Jigeeshu V., Brøchner, Anne C., Bestle, Morten H., Helleberg, Marie, Michelsen, Jens, Padmanaban, Ajay, Bose, Neeta, Møller, Anders, Borawake, Kapil, Kristiansen, Klaus T., Shukla, Urvi, Chew, Michelle S., Dixit, Subhal, Ulrik, Charlotte S., Amin, Pravin R., Chawla, Rajesh, Wamberg, Christian A., Shah, Mehul S., Darfelt, Iben S., Jørgensen, Vibeke L., Smitt, Margit, Granholm, Anders, Kjær, Maj-Brit N., Møller, Morten H., Meyhoff, Tine S., Vesterlund, Gitte K., Hammond, Naomi E., Micallef, Sharon, Bassi, Abhinav, John, Oommen, Jha, Anubhuti, Cronhjort, Maria, Jakob, Stephan M., Gluud, Christian, Lange, Theis, Kadam, Vaijayanti, Marcussen, Klaus V., Hollenberg, Jacob, Hedman, Anders, Nielsen, Henrik, Schjørring, Olav L., Jensen, Marie Q., Leistner, Jens W., Jonassen, Trine B., Kristensen, Camilla M., Clapp, Esben C., Hjortsø, Carl J.S., Jensen, Thomas S., Halstad, Liv S., Bak, Emilie R.B., Zaabalawi, Reem, Metcalf-Clausen, Matias, Abdi, Suhayb, Hatley, Emma V., Aksnes, Tobias S., Gleipner-Andersen, Emil, Alarcón, A.Felix, Yamin, Gabriel, Heymowski, Adam, Berggren, Anton, la Cour, Kirstine, Weihe, Sarah, Pind, Alison H., Engstrøm, Janus, Jha, Vivekanand, Venkatesh, Balasubramanian, Perner, Anders, Hammond, Naomi, Munch, Marie Warrer, Møller, Morten Hylander

Publikováno v: In The Lancet Regional Health - Southeast Asia January 2024 20

Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia:The COVID STEROID 2 Randomized Trial

Autor: Munch, Marie W, Myatra, Sheila N, Vijayaraghavan, Bharath Kumar Tirupakuzhi, Saseedharan, Sanjith, Benfield, Thomas, Wahlin, Rebecka R, Rasmussen, Bodil S, Andreasen, Anne Sofie, Poulsen, Lone M, Cioccari, Luca, Khan, Mohd S, Kapadia, Farhad, Divatia, Jigeeshu V, Br��chner, Anne C, Bestle, Morten H, Helleberg, Marie, Michelsen, Jens, Padmanaban, Ajay, Bose, Neeta, M��ller, Anders, Borawake, Kapil, Kristiansen, Klaus T, Shukla, Urvi, Chew, Michelle S, Dixit, Subhal, Ulrik, Charlotte S, Amin, Pravin R, Chawla, Rajesh, Wamberg, Christian A, Shah, Mehul S, Darfelt, Iben S, J��rgensen, Vibeke L, Smitt, Margit, Granholm, Anders, Kj��r, Maj-Brit N, M��ller, Morten H, Meyhoff, Tine S, Vesterlund, Gitte K, Hammond, Naomi E, Micallef, Sharon, Bassi, Abhinav, John, Oommen, Jha, Anubhuti, Cronhjort, Maria, Jakob, Stephan M, Gluud, Christian, Lange, Theis, Kadam, Vaijayanti, Marcussen, Klaus V, Hollenberg, Jacob, Hedman, Anders, Nielsen, Henrik, Schj��rring, Olav L, Jensen, Marie Q, Leistner, Jens W, Jonassen, Trine B, Kristensen, Camilla M, Clapp, Esben C, Hjorts��, Carl J S, Jensen, Thomas S, Halstad, Liv S, Bak, Emilie R B, Zaabalawi, Reem, Metcalf-Clausen, Matias, Abdi, Suhayb, Hatley, Emma V, Aksnes, Tobias S, Gleipner-Andersen, Emil, Alarc��n, Arif F, Yamin, Gabriel, Heymowski, Adam, Berggren, Anton, La Cour, Kirstine, Weihe, Sarah, Pind, Alison H, Engstr��m, Janus, Jha, Vivekanand, Venkatesh, Balasubramanian, Perner, Anders

Publikováno v: COVID STEROID 2 Trial Group, Rasmussen, B S, Nielsen, H & Schjørring, O L 2021, ' Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia : The COVID STEROID 2 Randomized Trial ', JAMA: The Journal of the American Medical Association, vol. 326, no. 18, pp. 1807-1817 . https://doi.org/10.1001/jama.2021.18295
Munch, M W, Myatra, S N, Vijayaraghavan, B K T, Saseedharan, S, Benfield, T, Wahlin, R R, Rasmussen, B S, Andreasen, A S, Poulsen, L M, Cioccari, L, Khan, M S, Kapadia, F, Divatia, J V, Brochner, A C, Bestle, M H, Helleberg, M, Michelsen, J, Padmanaban, A, Bose, N, Møller, A, Borawake, K, Kristiansen, K T, Shukla, U, Chew, M S, Dixit, S, Ulrik, C S, Amin, P R, Chawla, R, Wamberg, C A, Shah, M S, Darfelt, I S, Jorgensen, V L, Smitt, M, Granholm, A, Kjær, M-B N, Møller, M H, Meyhoff, T S, Vesterlund, G K, Hammond, N E, Micallef, S, Bassi, A, John, O, Jha, A, Cronhjort, M, Jakob, S M, Gluud, C, Lange, T, Kadam, V, Marcussen, K V, Hollenberg, J, Hedman, A, Nielsen, H, Schjorring, O L, Jensen, M Q, Leistner, J W, Jonassen, T B, Kristensen, C M, Clapp, E C, Hjortso, C J S, Jensen, T S, Halstad, L S, Bak, E R B, Zaabalawi, R, Metcalf-Clausen, M, Abdi, S, Hatley, E V, Aksnes, T S, Gleipner-Andersen, E, Alarcon, A F, Yamin, G, Heymowski, A, Berggren, A, La Cour, K, Weihe, S, Pind, A H, Engstrom, J, Jha, V, Venkatesh, B & Perner, A 2021, ' Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia The COVID STEROID 2 Randomized Trial ', J A M A: The Journal of the American Medical Association, vol. 326, no. 18, pp. 1807-1817 . https://doi.org/10.1001/jama.2021.18295
COVID STEROID 2 Trial Group 2021, ' Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia : The COVID STEROID 2 Randomized Trial ', JAMA: The Journal of the American Medical Association, vol. 326, no. 18, pp. 1807-1817 . https://doi.org/10.1001/jama.2021.18295
The COVID STEROID 2 Trial Group 2021, ' Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive without Life Support in Adults with COVID-19 and Severe Hypoxemia : The COVID STEROID 2 Randomized Trial ', JAMA-Journal of the American Medical Association, vol. 326, no. 18, pp. 1807-1817 . https://doi.org/10.1001/jama.2021.18295

Importance A daily dose with 6 mg of dexamethasone is recommended for up to 10 days in patients with severe and critical COVID-19, but a higher dose may benefit those with more severe disease. Objective To assess the effects of 12 mg/d vs 6 mg/d of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adc4ced93a6a128adc2824e55d4fc00
https://vbn.aau.dk/da/publications/04a329c2-9c2e-411e-8d5b-9bf36f405df6

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