Assessment of the safety, pharmacokinetics and pharmacodynamics of GSK3335065, an inhibitor of kynurenine monooxygenase, in a randomised placebo-controlled first-in-human study in healthy volunteers.

Autor: Fernando D; Clinical Unit Cambridge, Addenbrookes Centre for Clinical Investigation, Cambridge, UK., Dimelow R; GlaxoSmithKline Medicines Research Centre, Stevenage, UK., Gorey C; GlaxoSmithKline Medicines Research Centre, Stevenage, UK., Zhu X; GlaxoSmithKline Medicines Research Centre, Stevenage, UK., Muya C; GlaxoSmithKline Medicines Research Centre, Stevenage, UK., Parker C; GlaxoSmithKline David Jack Centre, Ware, UK., Wright W; GlaxoSmithKline David Jack Centre, Ware, UK., Soleman S; Clinical Unit Cambridge, Addenbrookes Centre for Clinical Investigation, Cambridge, UK., Walsh S; Clinical Unit Cambridge, Addenbrookes Centre for Clinical Investigation, Cambridge, UK., Crause M; Clinical Unit Cambridge, Addenbrookes Centre for Clinical Investigation, Cambridge, UK., Vlasakakis G; GlaxoSmithKline Medicines Research Centre, Stevenage, UK., Guiney W; GlaxoSmithKline David Jack Centre, Ware, UK., Robertson N; GlaxoSmithKline David Jack Centre, Ware, UK., Bergeal M; GlaxoSmithKline David Jack Centre, Ware, UK., Cui Y; GlaxoSmithKline Medicines Research Centre, Stevenage, UK., Krug AW; Vertex Pharmaceuticals, Boston, MA, USA., Uings I; GlaxoSmithKline Medicines Research Centre, Stevenage, UK.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2022 Feb; Vol. 88 (2), pp. 865-870. Date of Electronic Publication: 2021 Aug 22.

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Autor: Walker AL; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK., Ancellin N; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Beaufils B; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Bergeal M; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK., Binnie M; Centre for Cardiovascular Science, University of Edinburgh , Edinburgh EH16 4TJ, UK., Bouillot A; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Clapham D; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK., Denis A; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Haslam CP; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK., Holmes DS; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK., Hutchinson JP; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK., Liddle J; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK., McBride A; Centre for Cardiovascular Science, University of Edinburgh , Edinburgh EH16 4TJ, UK., Mirguet O; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Mowat CG; EastChem School of Chemistry, University of Edinburgh , Edinburgh EH9 3FJ, UK., Rowland P; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK., Tiberghien N; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Trottet L; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Uings I; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK., Webster SP; Centre for Cardiovascular Science, University of Edinburgh , Edinburgh EH16 4TJ, UK., Zheng X; MRC Centre for Inflammation Research, University of Edinburgh , Edinburgh EH16 4TJ, UK., Mole DJ; MRC Centre for Inflammation Research, University of Edinburgh , Edinburgh EH16 4TJ, UK.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Apr 27; Vol. 60 (8), pp. 3383-3404. Date of Electronic Publication: 2017 Apr 11.

Cryptocephalus signatifrons Suffrian, 1847 bien présent en Belgique (Coleoptera, Chrysomelidae, Cryptocephalinae). Entretiens sur les Chrysomelidae de Belgique et des régions limitrophes 16.

Autor: Fagot, Jean¹ jean.fagot@uliege.be, Poncin, Jacky² poncinja@skynet.be

Publikováno v: Bulletin De La Societe Royale Belge d'Etomologie. 2023, Vol. 158 Issue 3, p213-220. 8p.

Interactions of IDO and the Kynurenine Pathway with Cell Transduction Systems and Metabolism at the Inflammation–Cancer Interface.

Autor: Stone, Trevor W.¹ (AUTHOR) richard.williams@kennedy.ox.ac.uk, Williams, Richard O.¹ (AUTHOR)

Publikováno v: Cancers. Jun2023, Vol. 15 Issue 11, p2895. 29p.

Past and current climate as a driver in shaping the distribution of the Longitarsus candidulus species group (Coleoptera: Chrysomelidae).

Autor: Biondi, Maurizio, D'Alessandro, Paola, Salvi, Daniele, Berrilli, Emanuele, Iannella, Mattia

Publikováno v: Journal of Insect Science; Sep2024, Vol. 24 Issue 5, p1-13, 13p