DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

Autor: Georgiadis, P, Gavriil, M, Rantakokko, P, Ladoukakis, E, Botsivali, M, Kelly, RS, Bergdahl, IA, Kiviranta, H, Vermeulen, RCH, Spaeth, F, Hebbels, DGAJ, Kleinjans, JCS, de Kok, TMCM, Palli, D, Vineis, P, Kyrtopoulos, SA, Gottschalk, R, van Leeuwen, D, Timmermans, L, Bendinelli, B, Portengen, L, Saberi-Hosnijeh, F, Melin, B, Hallmans, G, Lenner, P, Keun, HC, Siskos, A, Athersuch, TJ, Kogevinas, M, Stephanou, EG, Myridakis, A, Fazzo, L, De Santis, M, Comba, P, Airaksinen, R, Ruokojärvi, P, Gilthorpe, M, Fleming, S, Fleming, T, Tu, Y-K, Jonsson, B, Lundh, T, Chen, WJ, Lee, W-C, Hsiao, CK, Chien, K-L, Kuo, P-H, Hung, H, Liao, S-F, EnviroGenomarkers consortium

Objectives: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma. Methods: We conducted an epige

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::49e1f1ab4e00a199669c2f90a8538980
https://eprints.whiterose.ac.uk/145459/1/1-s2.0-S0160412018325868-main.pdf

Performance in Omics Analyses of Blood Samples in Long-Term Storage: Opportunities for the Exploitation of Existing Biobanks in Environmental Health Research

Autor: Hebels DG, Georgiadis P, Keun HC, Athersuch TJ, Vineis P, Vermeulen R, Portengen L, Bergdahl IA, Hallmans G, Palli D, Bendinelli B, Krogh V, Tumino R, Sacerdote C, Kleinjans JC, de Kok TM, Smith MT, Kyrtopoulos SA, EnviroGenomarkers Project Consortium, PANICO, SALVATORE

Publikováno v: Environmental Health Perspectives
Environmental Health Perspectives, 121(4), 480-487. U.S. Department of Health and Human Services; National Institute of Environmental Health Sciences

Background: The suitability for omic analysis of biosamples collected in previous decades and currently stored in biobanks is unknown. Objectives: We evaluated the influence of handling and storage conditions of blood-derived biosamples on transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8604e52b0a7687ac082b0221ff197395
https://cris.maastrichtuniversity.nl/en/publications/5d1dbaf8-357e-4918-87c7-b44a1853f60d

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

Autor: Chatziioannou, A, Georgiadis, P, Hebels, DG, Liampa, I, Valavanis, I, Bergdahl, IA, Johansson, A, Palli, D, Chadeau-Hyam, M, Siskos, AP, Keun, H, Botsivali, M, De Kok, TMCM, Pérez, AE, Kleinjans, JCS, Vineis, P, Kyrtopoulos, SA, Gottschalk, R, Van Leeuwen, D, Timmermans, L, Bendinelli, B, Kelly, R, Vermeulen, R, Portengen, L, Saberi-Hosnijeh, F, Melin, B, Hallmans, G, Lenner, P, Athersuch, TJ, Kogevinas, M, Stephanou, EG, Myridakis, A, Fazzo, L, De Santis, M, Comba, P, Kiviranta, H, Rantakokko, P, Airaksinen, R, Ruokojarvi, P, Gilthorpe, M, Fleming, S, Fleming, T, Tu, YK, Jonsson, B, Lundh, T, Chen, WJ, Lee, WC, Hsiao, CK, Chien, KL, Kuo, PH, Hung, H, Liao, SF

We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2472b31c101ca8b17d3508f56399b761
https://dspace.library.uu.nl/handle/1874/361035

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.