Towards maximum acceleration of monoclonal antibody development: Leveraging transposase-mediated cell line generation to enable GMP manufacturing within 3 months using a stable pool.

Autor: Schmieder V; Cell Line Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Fieder J; Cell Line Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Drerup R; Early Stage Bioprocess Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Gutierrez EA; Early Stage Bioprocess Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Guelch C; Late Stage Upstream Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Stolzenberger J; Late Stage Downstream Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Stumbaum M; Early Stage Pharmaceutical Development, Pharmaceutical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Mueller VS; Early Stage Analytics, Analytical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Higel F; Early Stage Analytics, Analytical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Bergbauer M; Late Stage Analytics, Analytical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Bornhoefft K; Characterization Technologies, Analytical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Wittner M; Global CMC Experts NBE, Global Quality Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Gronemeyer P; Cell Banking & Inoculum, Focused Factory CS&T, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Braig C; CST Transfer, Focused Factory CS&T, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Huber M; Process Transfer Cell Culture, Focused Factory Drug Substance, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Reisenauer-Schaupp A; R&D PM NBE, Global R&D Project Management and Development Strategies, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Mueller MM; CMC PM Process Industrialization Germany, Global Biopharma CMC Project Mgmt&TechRA, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Schuette M; Global Technology Management, Global Innovation & Alliance Management, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Puengel S; Cell Line Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Lindner B; Cell Line Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Schmidt M; Cell Line Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Schulz P; Cell Line Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Fischer S; Cell Line Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany. Electronic address: simon.fischer@boerhinger-ingelheim.com.

Publikováno v: Journal of biotechnology [J Biotechnol] 2022 Apr 10; Vol. 349, pp. 53-64. Date of Electronic Publication: 2022 Mar 24.

Accuracy of fully automated oscillometric central aortic blood pressure measurement techniques.

Autor: Gotzmann M; University Hospital St Josef Hospital Bochum, Cardiology, Ruhr University Bochum., Hogeweg M; Department of Internal Medicine, Marien Hospital Witten, Witten., Seibert FS; University Hospital Marien Hospital Herne, Medical Department 1, Ruhr University Bochum, Herne, Germany., Rohn BJ; University Hospital Marien Hospital Herne, Medical Department 1, Ruhr University Bochum, Herne, Germany., Bergbauer M; Department of Internal Medicine, Marien Hospital Witten, Witten., Babel N; University Hospital Marien Hospital Herne, Medical Department 1, Ruhr University Bochum, Herne, Germany., Bauer F; University Hospital Marien Hospital Herne, Medical Department 1, Ruhr University Bochum, Herne, Germany., Mügge A; University Hospital St Josef Hospital Bochum, Cardiology, Ruhr University Bochum., Westhoff TH; University Hospital Marien Hospital Herne, Medical Department 1, Ruhr University Bochum, Herne, Germany.

Publikováno v: Journal of hypertension [J Hypertens] 2020 Feb; Vol. 38 (2), pp. 235-242.

Epstein–Barr Viruses: Their Immune Evasion Strategies and Implications for Autoimmune Diseases.

Autor: Zhao, Yuehong¹ (AUTHOR) yuehongzhao@link.cuhk.edu.cn, Zhang, Qi¹ (AUTHOR) qizhang7@link.cuhk.edu.cn, Zhang, Botian¹ (AUTHOR) botianzhang@link.cuhk.edu.cn, Dai, Yihao¹ (AUTHOR) yihaodai@link.cuhk.edu.cn, Gao, Yifei¹ (AUTHOR) yifeigao2@link.cuhk.edu.cn, Li, Chenzhong¹ (AUTHOR) lichenzhong@cuhk.edu.cn, Yu, Yijing¹ (AUTHOR) yuyijing@cuhk.edu.cn, Li, Conglei^1,2 (AUTHOR) yuyijing@cuhk.edu.cn

Publikováno v: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 15, p8160. 28p.

Hemodynamics of paradoxical severe aortic stenosis: insight from a pressure-volume loop analysis.

Autor: Gotzmann M; Cardiovascular Center, St. Josef Hospital Bochum, Ruhr-University Bochum, Gudrunstraße 56, 44791, Bochum, Germany. michael.gotzmann@ruhr-uni-bochum.de., Hauptmann S; Department of Cardiology, Marien Hospital Witten, Ruhr University Bochum, Witten, Germany., Hogeweg M; Cardiovascular Center, St. Josef Hospital Bochum, Ruhr-University Bochum, Gudrunstraße 56, 44791, Bochum, Germany., Choudhury DS; Department of Cardiology, Marien Hospital Witten, Ruhr University Bochum, Witten, Germany., Schiedat F; Cardiology and Angiology, Bergmannsheil, Ruhr University Bochum, Bochum, Germany., Dietrich JW; Department of Internal Medicine, Bergmannsheil, Ruhr University Bochum, Bochum, Germany., Westhoff TH; Medical Department I, University Hospital Marien Hospital Herne, Ruhr-University Bochum, Herne, Germany., Bergbauer M; Department of Cardiology, Marien Hospital Witten, Ruhr University Bochum, Witten, Germany., Mügge A; Cardiovascular Center, St. Josef Hospital Bochum, Ruhr-University Bochum, Gudrunstraße 56, 44791, Bochum, Germany.

Publikováno v: Clinical research in cardiology : official journal of the German Cardiac Society [Clin Res Cardiol] 2019 Aug; Vol. 108 (8), pp. 931-939. Date of Electronic Publication: 2019 Feb 08.

Epstein–Barr Virus DNA Exacerbates Arthritis in a Mouse Model via Toll-like Receptor 9.

Autor: Sherri, Nour¹ (AUTHOR) nas51@mail.aub.edu, Assaf, Rayan¹ (AUTHOR) ra448@aub.edu.lb, Bitar, Elio R.¹ (AUTHOR) erb07@mail.aub.edu, Znait, Sabah¹ (AUTHOR) sz60@aub.edu.lb, Borghol, Abdul Hamid¹ (AUTHOR) aib09@mail.aub.edu, Kassem, Aya¹ (AUTHOR) ak259@aub.edu.lb, Rahal, Elias A.^1,2 (AUTHOR) er00@aub.edu.lb

Publikováno v: International Journal of Molecular Sciences. May2024, Vol. 25 Issue 9, p4661. 14p.