Výsledky vyhledávání - "Berfin Gülave"

Nonlinear blood-brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix

Autor: Divakar Budda, Berfin Gülave, Johan G. C. van Hasselt, Elizabeth De Lange

Background & purpose Morphine is important for treatment of acute and chronic pain. However, there is high interpatient variability and often inadequate pain relief and adverse effects. To better understand variability in the dose effect relationship

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a32c97265bee61bd221a32e71142d212
https://doi.org/10.22541/au.168551715.56337335/v1

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Does nonlinear blood-brain barrier transport matter for morphine dosing strategies?

Autor: Berfin Gülave, Divakar Budda, Mohammed AA Saleh, JG Coen van Hasselt, Elizabeth CM de Lange

Morphine blood-brain barrier (BBB) transport is governed by passive diffusion, active efflux and saturable active influx. These processes may be associated with nonlinear concentration-dependencies which impact plasma and brain extracellular fluid (b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77cb0feac51a4758eec8fa26ff66fcfd
https://doi.org/10.1101/2023.03.17.533135

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The PBPK LeiCNS-PK3.0 framework predicts Nirmatrelvir (but not Remdesivir or Molnupiravir) to achieve effective concentrations against SARS-CoV-2 in human brain cells

Autor: Mohammed A.A. Saleh, Makoto Hirasawa, Ming Sun, Berfin Gülave, Jeroen Elassaiss-Schaap, Elizabeth C.M. de Lange

Publikováno v: European Journal of Pharmaceutical Sciences, 181:106345

SARS-CoV-2 was shown to infect and persist in the human brain cells up to 230 days, highlighting the need to treat the brain viral load. The CNS disposition of antiCOVID-19 drugs: Remdesivir, Molnupiravir, and Nirmatrelvir, remains, however, unexplor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012aeccf1118315f128d1a4cef45db0c
http://hdl.handle.net/1887/3502348

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Revealing the Neuroendocrine Response After Remoxipride Treatment Using Multi-Biomarker Discovery and Quantifying It by PK/PD Modeling

Autor: Piet H. van der Graaf, Elizatbeth C. M. de Lange, Yin Cheong Wong, Willem van den Brink, Berfin Gülave

Publikováno v: AAPS JOURNAL
AAPS JOURNAL, 19(1), 274–285

To reveal unknown and potentially important mechanisms of drug action, multi-biomarker discovery approaches are increasingly used. Time-course relationships between drug action and multi-biomarker profiles, however, are typically missing, while such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0b5a0003543d841dcd852a8425070d
https://doi.org/10.1208/s12248-016-0002-3

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