Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Beren Aylan"'
Publikováno v:
FEBS Open Bio, Vol 13, Iss 7, Pp 1204-1217 (2023)
Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) have evolved diverse strategies to counteract macrophage defence mechanisms including phagolysosomal biogenesis. Within macrophages, Mtb initially resides inside membrane‐bound phagos
Externí odkaz:
https://doaj.org/article/48ccaad7467f4b5b89f634f0ce83e8fc
Autor:
Claudio Bussi, Tiaan Heunis, Enrica Pellegrino, Elliott M. Bernard, Nourdine Bah, Mariana Silva Dos Santos, Pierre Santucci, Beren Aylan, Angela Rodgers, Antony Fearns, Julia Mitschke, Christopher Moore, James I. MacRae, Maria Greco, Thomas Reinheckel, Matthias Trost, Maximiliano G. Gutierrez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Extensive lysosomal damage can result in cell death but how limited protease leakage affects cytoplasmic organelles in viable cells is not well understood. Here the authors show that limited lysosomal damage leads to changes in the mitochondrial prot
Externí odkaz:
https://doaj.org/article/1b0eea4b126e4d9fbd71cb879e06a954
Autor:
Melissa Bedard, Sanne van der Niet, Elliott M. Bernard, Gregory Babunovic, Tan-Yun Cheng, Beren Aylan, Anita E. Grootemaat, Sahadevan Raman, Laure Botella, Eri Ishikawa, Mary P. O’Sullivan, Seónadh O’Leary, Jacob A. Mayfield, Jeffrey Buter, Adriaan J. Minnaard, Sarah M. Fortune, Leon O. Murphy, Daniel S. Ory, Joseph Keane, Sho Yamasaki, Maximiliano G. Gutierrez, Nicole van der Wel, D. Branch Moody
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche. Here, we show that a terpenyl
Externí odkaz:
https://doaj.org/article/66ad604010504fdab74173379c2c7ca6
Autor:
Pierre Santucci, Beren Aylan, Laure Botella, Elliott M. Bernard, Claudio Bussi, Enrica Pellegrino, Natalia Athanasiadi, Maximiliano G. Gutierrez
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Mycobacterium tuberculosis segregates within multiple subcellular niches with different biochemical and biophysical properties that, upon treatment, may impact antibiotic distribution, accumulation, and efficacy. However, it remains unclear
Externí odkaz:
https://doaj.org/article/2c0c7d95b85240ef84d2a4ae39af13bd
Autor:
Beren Aylan, Elliott M. Bernard, Enrica Pellegrino, Laure Botella, Antony Fearns, Natalia Athanasiadi, Claudio Bussi, Pierre Santucci, Maximiliano G. Gutierrez
Autophagy is a cellular innate-immune defence mechanism against intracellular microorganisms, including Mycobacterium tuberculosis (Mtb). How canonical and non-canonical autophagy function to control Mtb infection in phagosomes and the cytosol remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3369f69bc5356a8f9ecc6f3169a84ecb
Autor:
Pierre Santucci, Beren Aylan, Laure Botella, Elliott M. Bernard, Claudio Bussi, Enrica Pellegrino, Natalia Athanasiadi, Maximiliano G. Gutierrez
SummaryThe intracellular population of Mycobacterium tuberculosis (Mtb) is dynamically segregated within multiple subcellular niches with different biochemical and biophysical properties that, upon treatment, may impact antibiotic distribution, accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61abd354a72ed6233087d8bb6399f46b
https://doi.org/10.1101/2021.12.20.473466
https://doi.org/10.1101/2021.12.20.473466