Computational Microbiome Pharmacology Analysis Elucidates the Anti-Cancer Potential of Vaginal Microbes and Metabolites.

Autor: Lawore DC, Jena S, Berard AR, Birse K, Lamont A, Mackelprang RD, Noel-Romas L, Perner M, Hou X, Irungu E, Mugo N, Knodel S, Muwonge TR, Katabira E, Hughes SM, Levy C, Calienes FL, Hladik F, Lingappa JR, Burgener AD, Green LN, Brubaker DK

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.

Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus.

Autor: Farr Zuend C; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, USA. christina.farr@case.edu., Lamont A; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada., Noel-Romas L; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, USA.; Department of Obstetrics, Gynecology & Reproductive Sciences, University of Manitoba, Winnipeg, Canada., Knodel S; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, USA.; Department of Obstetrics, Gynecology & Reproductive Sciences, University of Manitoba, Winnipeg, Canada., Birse K; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, USA.; Department of Obstetrics, Gynecology & Reproductive Sciences, University of Manitoba, Winnipeg, Canada., Kratzer K; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada., McQueen P; JC Wilt Infectious Disease Research Centre, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada., Perner M; JC Wilt Infectious Disease Research Centre, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada., Ayele H; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, USA.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada., Mutch S; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada., Berard AR; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, USA.; Department of Obstetrics, Gynecology & Reproductive Sciences, University of Manitoba, Winnipeg, Canada., Schellenberg JJ; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada., Senturk F; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, USA., McCorrister S; JC Wilt Infectious Disease Research Centre, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada., Westmacott G; JC Wilt Infectious Disease Research Centre, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada., Mulhall F; Health Sciences Centre, Winnipeg, Canada., Sandberg B; Health Sciences Centre, Winnipeg, Canada., Yu A; Department of Obstetrics, Gynecology & Reproductive Sciences, University of Manitoba, Winnipeg, Canada., Burnett M; Department of Obstetrics, Gynecology & Reproductive Sciences, University of Manitoba, Winnipeg, Canada., Poliquin V; Department of Obstetrics, Gynecology & Reproductive Sciences, University of Manitoba, Winnipeg, Canada., Burgener AD; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, USA. adam.burgener@case.edu.; Department of Obstetrics, Gynecology & Reproductive Sciences, University of Manitoba, Winnipeg, Canada. adam.burgener@case.edu.; Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden. adam.burgener@case.edu.

Publikováno v: Microbiome [Microbiome] 2023 Jul 25; Vol. 11 (1), pp. 159. Date of Electronic Publication: 2023 Jul 25.

Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling.

Autor: Berard AR; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Brubaker DK; Weldon School of Biomedical Engineering and Regenstrief Center for Healthcare Engineering, Purdue University, West Lafayette, IN 47907, USA., Birse K; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Lamont A; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada., Mackelprang RD; Department of Global Health, University of Washington, Seattle, WA 98105, USA., Noël-Romas L; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Perner M; Medical Microbiology and Infectious Disease University of Manitoba, Winnipeg, MB R3E 0J9, Canada., Hou X; Department of Global Health, University of Washington, Seattle, WA 98105, USA., Irungu E; Partners in Health Research and Development, Kenya Medical Research Institute, Mbagathi Road, Nairobi, Kenya., Mugo N; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Partners in Health Research and Development, Kenya Medical Research Institute, Mbagathi Road, Nairobi, Kenya., Knodel S; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Muwonge TR; Infectious Disease Institute, Makerere University, Makerere, Kampala, Uganda., Katabira E; Infectious Disease Institute, Makerere University, Makerere, Kampala, Uganda., Hughes SM; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA., Levy C; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA., Calienes FL; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Lauffenburger DA; Department of Biological Engineering, MIT, Cambridge, MA 02142, USA., Baeten JM; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Gilead Sciences, Foster City, CA 94404, USA., Celum C; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA., Hladik F; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Lingappa J; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA., Burgener AD; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Medicine Solna, Karolinska Institutet, Framstegsgatan, 171 64 Solna, Sweden. Electronic address: adam.burgener@case.edu.

Publikováno v: Cell reports [Cell Rep] 2023 May 30; Vol. 42 (5), pp. 112474. Date of Electronic Publication: 2023 May 06.

Simian Immunodeficiency Virus Susceptibility, Immunology, and Microbiome in the Female Genital Tract of Adolescent Versus Adult Pigtail Macaques.

Autor: Berard AR; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, Canada., Miller C; Department of Pediatrics, University of Miami, Miami, Florida, USA.; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA., Araínga M; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, Louisiana, USA., Broedlow CA; Department of Pediatrics, University of Miami, Miami, Florida, USA.; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA., Noël-Romas L; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, Canada., Schifanella L; Division of Surgical Outcomes and Precision Medicine Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA., Hensley-McBain T; Department of Pediatrics, University of Miami, Miami, Florida, USA.; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA., Roederer A; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA., Driscoll CB; Department of Pediatrics, University of Miami, Miami, Florida, USA.; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA., Coronado E; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA., Manuzak J; Department of Pediatrics, University of Miami, Miami, Florida, USA.; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA., McKinnon LR; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada., Villinger F; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, Louisiana, USA., Hope TJ; Department of Cell & Molecular Biology, Northwestern University, Chicago, Illinois, USA., Burgener AD; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, Canada.; Center for Global Health and Disease, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Klatt NR; Department of Pediatrics, University of Miami, Miami, Florida, USA.; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.; Division of Surgical Outcomes and Precision Medicine Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.

Publikováno v: AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2021 Jul; Vol. 37 (7), pp. 510-522. Date of Electronic Publication: 2021 Jun 22.

Treatment with Commonly Used Antiretroviral Drugs Induces a Type I/III Interferon Signature in the Gut in the Absence of HIV Infection.

Autor: Hughes SM; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA., Levy CN; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA., Calienes FL; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Stekler JD; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Pandey U; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA., Vojtech L; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA., Berard AR; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada., Birse K; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA., Noël-Romas L; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA., Richardson B; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Golden JB; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Cartwright M; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Collier AC; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA., Stevens CE; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA., Curlin ME; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.; Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand.; Department of Medicine, Division of Infectious Diseases, Oregon Health and Sciences University, Portland, OR, USA., Holtz TH; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.; Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand., Mugo N; Partners in Health Research and Development, Kenya Medical Research Institute, Thika, Kenya.; Center for Clinical Research (CCR), Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.; Department of Global Health, University of Washington, Seattle, WA, USA., Irungu E; Partners in Health Research and Development, Kenya Medical Research Institute, Thika, Kenya., Katabira E; Infectious Disease Institute, Makerere University, Kampala, Uganda., Muwonge T; Infectious Disease Institute, Makerere University, Kampala, Uganda., Lama JR; Asociación Civil Impacta Salud y Educación, Lima, Peru., Baeten JM; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Burgener A; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA.; Departments of Obstetrics & Gynecology and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.; Unit of Infectious Diseases, Department of Medicine Solna, Centre for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden., Lingappa JR; Department of Pediatrics, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Mackelprang R; Department of Global Health, University of Washington, Seattle, WA, USA., McGowan I; Orion Biotechnology, Ottawa, ON, Canada.; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Cranston RD; Department of Infectious Diseases and Dermatology, University of Barcelona, Barcelona, Spain., Cameron MJ; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Hladik F; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2020 Sep 22; Vol. 1 (6), pp. 100096. Date of Electronic Publication: 2020 Sep 22.