Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues.

Autor: Carneiro VM; Institute of Chemistry, University of Campinas, UNICAMP, C.P. 6154, 13084-971 Campinas, SP, Brazil., Trivella DB; National Center for Research in Energy and Material, Brazilian Biosciences National Laboratory, 13083-100 Campinas, SP, Brazil., Scorsato V; Institute of Chemistry, University of Campinas, UNICAMP, C.P. 6154, 13084-971 Campinas, SP, Brazil., Beraldo VL; National Center for Research in Energy and Material, Brazilian Biosciences National Laboratory, 13083-100 Campinas, SP, Brazil., Dias MP; Institute of Chemistry, University of Campinas, UNICAMP, C.P. 6154, 13084-971 Campinas, SP, Brazil., Sobreira TJ; National Center for Research in Energy and Material, Brazilian Biosciences National Laboratory, 13083-100 Campinas, SP, Brazil., Aparicio R; Institute of Chemistry, University of Campinas, UNICAMP, C.P. 6154, 13084-971 Campinas, SP, Brazil., Pilli RA; Institute of Chemistry, University of Campinas, UNICAMP, C.P. 6154, 13084-971 Campinas, SP, Brazil. Electronic address: pilli@iqm.unicamp.br.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2015 Jun 05; Vol. 97, pp. 42-54. Date of Electronic Publication: 2015 Apr 20.