Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2 ^R47H Alzheimer's risk gene mutation.

Autor: Johnston KG; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, 92697, USA., Berackey BT; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, 92697, USA.; Department of Biomedical Engineering, University of California, Irvine, CA, 92697, USA., Tran KM; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, 92697, USA., Gelber A; Department of Cognitive Science, University of California, San Diego, CA, 92037, USA., Yu Z; Department of Statistics, School of Computer and Information Science, University of California, Irvine, CA, 92697, USA.; Center for Neural Circuit Mapping, University of California, Irvine, CA, 92697, USA., MacGregor GR; Department of Developmental and Cell Biology, University of California, Irvine, CA, 92697, USA.; Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, USA., Mukamel EA; Department of Cognitive Science, University of California, San Diego, CA, 92037, USA., Tan Z; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, 92697, USA.; Center for Neural Circuit Mapping, University of California, Irvine, CA, 92697, USA.; Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, USA.; Department of Molecular Biology and Biochemistry School of Biological Sciences, University of California, Irvine, CA, 92697, USA., Green KN; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, 92697, USA.; Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, USA., Xu X; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, 92697, USA. xiangmix@uci.edu.; Department of Biomedical Engineering, University of California, Irvine, CA, 92697, USA. xiangmix@uci.edu.; Center for Neural Circuit Mapping, University of California, Irvine, CA, 92697, USA. xiangmix@uci.edu.; Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, USA. xiangmix@uci.edu.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2024 Aug 05. Date of Electronic Publication: 2024 Aug 05.