Updated assessment of risks and benefits of dolutegravir versus efavirenz in new antiretroviral treatment initiators in sub-Saharan Africa: modelling to inform treatment guidelines

Autor: Francois Venter, Loveleen Bansi-Matharu, Ruanne V. Barnabas, Tsitsi Apollo, Juliana Almeida da Silva, Silvia Bertagnolio, Owen Mugurungi, Andrew N. Phillips, Ravindra K. Gupta, Annemarie M. J. Wensing, Andreas Jahn, Elliot Raizes, Valentina Cambiano, George K. Siberry, Jennifer Cohn, Daniel R. Kuritzkes, Deenan Pillay, Alexandra Calmy, David Ripin, Anton Pozniak, Nathan Ford, John W. Mellors, Paul Revill, Jens D Lundgren, Diane V. Havlir

Publikováno v: The Lancet. HIV
The Lancet HIV, Vol. 7, No 3 (2020) pp. e193-e200
Phillips, A N, Bansi-Matharu, L, Venter, F, Havlir, D, Pozniak, A, Kuritzkes, D R, Wensing, A, Lundgren, J D, Pillay, D, Mellors, J, Cambiano, V, Jahn, A, Apollo, T, Mugurungi, O, Ripin, D, Da Silva, J, Raizes, E, Ford, N, Siberry, G K, Gupta, R K, Barnabas, R, Revill, P, Cohn, J, Calmy, A & Bertagnolio, S 2020, ' Updated assessment of risks and benefits of dolutegravir versus efavirenz in new antiretroviral treatment initiators in sub-Saharan Africa : modelling to inform treatment guidelines ', The Lancet HIV, vol. 7, no. 3, pp. e193-e200 . https://doi.org/10.1016/S2352-3018(19)30400-X

BACKGROUND: The integrase inhibitor dolutegravir is being considered in several countries in sub-Saharan Africa instead of efavirenz for people initiating antiretroviral therapy (ART) because of superior tolerability and a lower risk of resistance em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc92a4b1f277e8a737e130ba54367a1
https://www.repository.cam.ac.uk/handle/1810/303518

Dietary exposure to benzoxazinoids enhances bacteria-induced monokine responses by peripheral blood mononuclear cells

Autor: Yaseelan Palarasah, Michael Friberg Bruun Nielsen, Claus Henrik Nielsen, Lars K. Poulsen, Heidi J. Schnoor, Khem B. Adhikari, Inge S. Fomsgaard, Nanna Juel-Berg, Dres Damgaard, Bettina M. Jensen

Publikováno v: Damgaard, D, Jensen, B M, Palarasah, Y, Nielsen, M F B, Adhikari, K B, Schnoor, H J, Juel-Berg, N, Poulsen, L K, Fomsgaard, I S & Nielsen, C H 2015, ' Dietary exposure to benzoxazinoids enhances bacteria-induced monokine responses by peripheral blood mononuclear cells ', Molecular Nutrition & Food Research, vol. 59, no. 11, pp. 2190-2198 . https://doi.org/10.1002/mnfr.201500151

SCOPE: To examine potentially immunomodulating effects of dietary benzoxazinoids (BXs), present in cereal grains.METHODS AND RESULTS: Nineteen healthy volunteers were randomly distributed into two groups, who received diets with high or low content o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4c7cc4e09e009b184ae6b4b95ab12b
https://doi.org/10.1002/mnfr.201500151

Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals

Autor: Chantal Csajka, Amalio Telenti, Rubin Lubomirov, Laurent A. Decosterd, J. Di Iulio, Matthias Cavassini, Thierry Buclin, Margalida Rotger, Chin B. Eap, A Fayet, M. Arab-Alameddine, Jérôme Biollaz

Publikováno v: Clinical pharmacology and therapeutics
Europe PubMed Central
Clinical Pharmacology and Therapeutics, Vol. 85, No 5 (2009) pp. 485-494

Besides CYP2B6, other polymorphic enzymes contribute to efavirenz (EFV) interindividual variability. This study was aimed at quantifying the impact of multiple alleles on EFV disposition. Plasma samples from 169 human immunodeficiency virus (HIV) pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e83a2266557bd84e99ebd1bd9ade31d

Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid

Autor: Alexia, Cusini, Pietro L, Vernazza, Sabine, Yerly, Laurent A, Decosterd, Bruno, Ledergerber, Christoph A, Fux, Janine, Rohrbach, Nicolas, Widmer, Bernhard, Hirschel, Roman, Gaudenz, Matthias, Cavassini, Thomas, Klimkait, Franziska, Zenger, Chistine, Gutmann, Milos, Opravil, Huldyrich F, Günthard, S, Yerly

Publikováno v: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 62, No 1 (2013) pp. 28-35

Objectives: To determine HIV-1 RNA in cerebrospinal fluid (CSF) of successfully treated patients and to evaluate if combination antiretroviral treatments with higher central nervous system penetration-effectiveness (CPE) achieve better CSF viral supp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69ea5966e74f36ca5a297559404ddb2
https://pubmed.ncbi.nlm.nih.gov/24135736

Virological and immunological responses to efavirenz or boosted lopinavir as first-line therapy for patients with HIV

Autor: James Young, Pietro Vernazza, Huldrych F. Guenthard, Heiner C. Bucher, Christoph A Fux, Enos Bernasconi, Matthias Cavassini, Martin Rickenbach, Bernard Hirschel, Manuel Battegay

Publikováno v: Antiviral Therapy, Vol. 14, No 6 (2009) pp. 771-779

Background Efavirenz and lopinavir boosted with ritonavir are both recommended as first-line therapies for patients with HIV when combined with two nucleoside reverse transcriptase inhibitors. It is uncertain which therapy is more effective for patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70445a6ba1e1fd9b2d76126c8725d007
https://pubmed.ncbi.nlm.nih.gov/19812439