Insights into the biased activity of dextromethorphan and haloperidol towards SARS-CoV-2 NSP6: in silico binding mechanistic analysis

Autor: Vijay Kumar, Preeti Pandey, Amresh Prakash, Kartikay Prasad

Publikováno v: Journal of Molecular Medicine
Journal of Molecular Medicine (Berlin, Germany)

The outbreak of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus continually led to infect a large population worldwide. SARS-CoV-2 utilizes its NSP6 and Orf9c proteins to interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f1fd09afbafdbae1a0443c8831604a
https://doi.org/10.1007/s00109-020-01980-1

The Opiate Receptor: A Model Explaining Structure-Activity Relationships of Opiate Agonists and Antagonists

Autor: Feinberg, Andrew P., Creese, Ian, Snyder, Solomon H.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1976 Nov 01. 73(11), 4215-4219.

Externí odkaz: https://www.jstor.org/stable/66486

Asymmetric synthesis of (1R, 5S)-2-methyl-6, 7-benzomorphan via Aza-Prins reaction

Autor: María D. Díaz-de-Villegas, Ramón Badorrey, José A. Gálvez, Alejandro Mahía

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
Universitat Politècnica de Catalunya (UPC)
Digital.CSIC. Repositorio Institucional del CSIC
instname

(1R,5S)-2-Methyl-6,7-benzomorphan has been synthesised from (R)-(benzyloxy)(phenyl)acetaldehyde. On a 2-mmol scale Bi (OTf)3 promoted Aza-Prins reaction with N-tosylhomoallylamine afforded an 88/12 mixture of 6-oxa-2-azabicyclo[3.2.1]octanes. Major d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d00fc917e869816ffae52d7e116ddc
http://zaguan.unizar.es/record/117942

Synthesis and Structure-Activity Relationships of (−)-cis-N-Normetazocine-Based LP1 Derivatives

Autor: Rita Turnaturi, Girolamo Calo, Lucia Montenegro, Emanuela Arena, Emanuele Amata, Carmela Parenti, Lorella Pasquinucci, Valeria Camarda, Zafiroula Georgoussi, Paschalina Pallaki

Publikováno v: Pharmaceuticals; Volume 11; Issue 2; Pages: 40

(−)-cis-N-Normetazocine represents a rigid scaffold able to mimic the tyramine moiety of endogenous opioid peptides, and the introduction of different N-substituents influences affinity and efficacy of respective ligands at MOR (mu opioid receptor)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef17583ca4af7df71536f53b7af1466d

((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist

Autor: Giulia Russo, Carmela Parenti, Orazio Prezzavento, Lucia Montenegro, Santina Chiechio, Federica Ferrari, Emanuela Arena, Rita Turnaturi, Francesco Pappalardo, Lorella Pasquinucci, Girolamo Calo

The pivotal role of the stereocenter at the N-substituent of the 6,7-benzomorphan scaffold was investigated combining synthetic and pharmacological approaches. 2R- and 2S-diastereoisomers of the multitarget MOR/DOR antinociceptive ligand LP2 (1) were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b24f10e23ad7e99956e65444db13514
http://hdl.handle.net/20.500.11769/360728