Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer's disease continuum.

Autor: Wen J; Laboratory of AI and Biomedical Science (LABS), University of Southern California, Los Angeles, CA, USA. Junhao.wen89@gmail.com., Yang Z; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nasrallah IM; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cui Y; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Erus G; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Srinivasan D; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Abdulkadir A; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Research Lab in Neuroimaging of the Department of Clinical Neurosciences at Lausanne University Hospital, Lausanne, Switzerland., Mamourian E; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hwang G; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Singh A; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bergman M; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bao J; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Varol E; Department of Statistics, Center for Theoretical Neuroscience, Zuckerman Institute, Columbia University, New York, NY, USA., Zhou Z; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Boquet-Pujadas A; Laboratory of AI and Biomedical Science (LABS), University of Southern California, Los Angeles, CA, USA., Chen J; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Toga AW; Laboratory of NeuroImaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Saykin AJ; Radiology and Imaging Sciences, Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana Alzheimer's Disease Research Center and the Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Vanderbilt Genetics Institute, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA., Villeneuve S; Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada., Gollub R; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Sotiras A; Department of Radiology and Institute for Informatics, Washington University School of Medicine, St. Louis, MO, USA., Wittfeld K; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Tosun D; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA., Bilgel M; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD, USA., An Y; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD, USA., Marcus DS; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA., LaMontagne P; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Benzinger TL; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Heckbert SR; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA., Austin TR; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA., Launer LJ; Neuroepidemiology Section, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA., Espeland M; Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA., Masters CL; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Maruff P; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Fripp J; CSIRO Health and Biosecurity, Australian e-Health Research Centre CSIRO, Brisbane, QLD, Australia., Johnson SC; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Morris JC; Knight Alzheimer Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA., Albert MS; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bryan RN; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Resnick SM; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD, USA., Ferrucci L; Translational Gerontology Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, MedStar Harbor Hospital, 3001 S. Hanover Street, Baltimore, MD, 21225, USA., Fan Y; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Habes M; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Wolk D; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Neurology and Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA., Shen L; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Shou H; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Davatzikos C; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Christos.Davatzikos@pennmedicine.upenn.edu.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2024 Oct 05; Vol. 14 (1), pp. 420. Date of Electronic Publication: 2024 Oct 05.

Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease.

Autor: Millar PR; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA. pmillar@wustl.edu., Gordon BA; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA., Wisch JK; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Schultz SA; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., Benzinger TL; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA., Cruchaga C; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA., Hassenstab JJ; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Ibanez L; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.; NeuroGenomics & Informatics Center, Washington University in St. Louis, St. Louis, MO, USA., Karch C; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA., Llibre-Guerra JJ; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Morris JC; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Perrin RJ; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.; Department of Pathology & Immunology, Washington University in St. Louis, St. Louis, MO, USA., Supnet-Bell C; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Xiong C; Department of Biostatistics, Washington University in St. Louis, St. Louis, MO, USA., Allegri RF; Instituto Neurológico Fleni, Buenos Aires, Argentina., Berman SB; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Chhatwal JP; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., Chrem Mendez PA; Instituto Neurológico Fleni, Buenos Aires, Argentina., Day GS; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Hofmann A; German Center for Neurodegenerative Diseases (DZNE), 72076, Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076, Tübingen, Germany., Ikeuchi T; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan., Jucker M; German Center for Neurodegenerative Diseases (DZNE), 72076, Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076, Tübingen, Germany., Lee JH; Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Levin J; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Lopera F; Universidad de Antioquia, Medellín, Colombia., Niimi Y; Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Bunkyo-Ku, Tokyo, Japan., Sánchez-González VJ; Departamento de Clínicas, CUALTOS, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México., Schofield PR; Neuroscience Research Australia, Sydney, NSW, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia., Sosa-Ortiz AL; Instituto Nacional de Neurologia y Neurocirugía MVS, CDMX, Ciudad de México, Mexico., Vöglein J; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany., Bateman RJ; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Ances BM; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA., McDade EM; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2023 Dec 19; Vol. 18 (1), pp. 98. Date of Electronic Publication: 2023 Dec 19.

Brain aerobic glycolysis and resilience in Alzheimer disease.

Autor: Goyal MS; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.; Neuroimaging Labs Research Center, Washington University School of Medicine, St. Louis, MO 63110.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108.; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110., Blazey T; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.; Neuroimaging Labs Research Center, Washington University School of Medicine, St. Louis, MO 63110., Metcalf NV; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.; Neuroimaging Labs Research Center, Washington University School of Medicine, St. Louis, MO 63110., McAvoy MP; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.; Neuroimaging Labs Research Center, Washington University School of Medicine, St. Louis, MO 63110.; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63108., Strain JF; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.; Neuroimaging Labs Research Center, Washington University School of Medicine, St. Louis, MO 63110., Rahmani M; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.; Neuroimaging Labs Research Center, Washington University School of Medicine, St. Louis, MO 63110., Durbin TJ; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.; Neuroimaging Labs Research Center, Washington University School of Medicine, St. Louis, MO 63110., Xiong C; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108., Benzinger TL; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.; Neuroimaging Labs Research Center, Washington University School of Medicine, St. Louis, MO 63110.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108., Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108., Raichle ME; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.; Neuroimaging Labs Research Center, Washington University School of Medicine, St. Louis, MO 63110.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108.; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110.; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO 63130.; Department of Psychology & Brain Science, Washington University School of Medicine, St. Louis, MO 63130., Vlassenko AG; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.; Neuroimaging Labs Research Center, Washington University School of Medicine, St. Louis, MO 63110.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Feb 14; Vol. 120 (7), pp. e2212256120. Date of Electronic Publication: 2023 Feb 06.

Quantitative Gradient Echo MRI Identifies Dark Matter as a New Imaging Biomarker of Neurodegeneration that Precedes Tisssue Atrophy in Early Alzheimer's Disease.

Autor: Kothapalli SVVN; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA., Benzinger TL; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA., Aschenbrenner AJ; Knight Alzheimer Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Perrin RJ; Knight Alzheimer Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA.; The Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, USA., Hildebolt CF; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA., Goyal MS; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA.; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Fagan AM; Knight Alzheimer Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.; The Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, USA., Raichle ME; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA.; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.; The Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, USA., Morris JC; Knight Alzheimer Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Yablonskiy DA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA.; Knight Alzheimer Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA.; The Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, USA.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2022; Vol. 85 (2), pp. 905-924.

Falls: a marker of preclinical Alzheimer disease: a cohort study protocol.

Autor: Bollinger RM; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, Missouri, USA., Keleman A; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, Missouri, USA., Thompson R; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Westerhaus E; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Fagan AM; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Benzinger TL; Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA., Schindler SE; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Xiong C; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA., Balota D; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri, USA., Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Ances BM; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Stark SL; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, Missouri, USA sstark@wustl.edu.

Publikováno v: BMJ open [BMJ Open] 2021 Sep 15; Vol. 11 (9), pp. e050820. Date of Electronic Publication: 2021 Sep 15.