Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Benzilylcholine mustard"'
Autor:
Stanislav Tuček, Jan Jakubík
Publikováno v:
Scopus-Elsevier
We have found earlier that the neuromuscular blocker alcuronium binds to cardiac muscarinic receptors simultaneously with their specific antagonist [3H]methyl-N-scopolamine ([3H]NMS) and allosterically increases their affinity to this ligand. Nothing
Publikováno v:
Journal of Biological Chemistry. 275:18836-18844
After short preincubations with N-[(3)H]methylscopolamine ([(3)H]NMS) or R(-)-[(3)H]quinuclidinyl benzilate ([(3)H]QNB), radioligand dissociation from muscarinic M(1) receptors in Chinese hamster ovary cell membranes was fast, monoexponential, and in
Autor:
Jan Jakubík, Stanislav Tuček
1 By measuring the binding of N-[3H-methyl]-scopolamine ([3H]-NMS) and of unlabelled subtype-specific muscarinic antagonists, two populations of muscarinic binding sites can be distinguished in the membranes of cardiac ventricles taken from 1-day-old
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d2c72a2d01cb31fd244dd65b779fee
https://europepmc.org/articles/PMC1510540/
https://europepmc.org/articles/PMC1510540/
Publikováno v:
European journal of pharmacology. 187(2)
The aim of this study was to characterize muscarinic receptors of the bovine coronary artery by means of a combination of mechanical relaxation and contraction responses and radioligand binding data. Fresh helical strips of bovine coronary artery wit
Autor:
Jonas B. Galper, B T Liang
Publikováno v:
Journal of Biological Chemistry. 262:2494-2501
We have previously demonstrated that during embryonic development of the chick heart between days 2 1/2 and 10 days in ovo, muscarinic cholinergic inhibition of isoproterenol-stimulated adenylate cyclase activity increased 4-fold, and the sensitivity
Publikováno v:
Neurourology and Urodynamics. 2:317-321
In a recent study by Anderson and Marks [1982], indirect evidence was presented for the existence of “150-fold muscarinic receptor excess” in the rabbit urinary bladder. This conclusion was based on the quantitative comparison of the ability of c
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 67:331-343
The relationship between ion movements (sodium uptake and potassium release) and agonist-induced contractile responses or muscarinic receptor binding was investigated in the guinea pig ileal longitudinal muscle (GPLM). Sodium uptake and potassium rel
Autor:
B.A. Ger, Ella V. Zeimal
Publikováno v:
Brain Research. 121:131-149
Completely isolated identified neurones (LPed-2 and LPed-3) of the left pedal ganglion of Planorbarius corneus were shown to have two kinds of cholinoreceptors (ChR) on their membrane. One kind of ChR is a classical nicotinic receptor which is sensit
Publikováno v:
Journal of Pharmacy and Pharmacology. 24:950-954
Seven homologues of the alkylating muscarinic antagonist benzilylcholine mustard (BCM) have been prepared. The rate of reaction of the aziridinium ion derivatives with water is largely independent of the structure, whereas the rate of reaction with t
Autor:
J.M. Young, P. G. Reasbeck
Publikováno v:
British Journal of Pharmacology. 48:148-155
1. The histamine receptors of longitudinal muscle strips from guinea-pig ileum were inactivated on extended exposure to concentrations of benzilylcholine mustard (BCM) above 10(-6)M. These concentrations are 3 orders of magnitude greater than those r