Chalcone-based benzenesulfonamides as potent and selective inhibitors for human carbonic anhydrase II: Design, synthesis, in vitro, and in silico studies.

Autor: Lee HY; BK21 FOUR Team and Integrated Research, Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea., Elkamhawy A; Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Al-Karmalawy AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt., Nada H; BK21 FOUR Team and Integrated Research, Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea., Giovannuzzi S; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy., Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy., Lee K; BK21 FOUR Team and Integrated Research, Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Nov; Vol. 357 (11), pp. e2400069. Date of Electronic Publication: 2024 Sep 06.

Biophysical insight into the interaction mechanism of 4-bromo-N-(thiazol-2-yl)benzenesulfonamide and human serum albumin using multi-spectroscopic and computational studies.

Autor: Ayimbila F; Center for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700 Thailand., Phopin K; Center for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700 Thailand; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700 Thailand., Ruankham W; Center for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700 Thailand., Pingaew R; Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110 Thailand., Prachayasittikul S; Center for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700 Thailand., Prachayasittikul V; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700 Thailand., Tantimongcolwat T; Center for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700 Thailand. Electronic address: tanawut.tan@mahidol.ac.th.

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Jan 01; Vol. 204, pp. 106961. Date of Electronic Publication: 2024 Nov 09.

Novel benzenesulfonamide derivatives as potential selective carbonic anhydrase IX, XII inhibitors with anti-proliferative activity: Design, synthesis and in silico studies.

Autor: Fadaly WAA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt., Mohamed FEA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt., Nemr MTM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street, 11562 Cairo, Egypt. Electronic address: Mohamed.nemr@pharma.cu.edu.eg., Sayed AM; Department of Pharmacognosy, Collage of Pharmacy, Almaaqal University, 61014 Basrah, Iraq., Khalil RG; Immunology Division, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt., Zidan TH; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Dec; Vol. 153, pp. 107881. Date of Electronic Publication: 2024 Oct 10.

4-(Pyrazolyl)benzenesulfonamide Ureas as Carbonic Anhydrases Inhibitors and Hypoxia-Mediated Chemo-Sensitizing Agents in Colorectal Cancer Cells.

Autor: Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia Street, Alexandria 21648, Egypt., Fares M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, Egypt.; Sydney Pharmacy School, The University of Sydney, Sydney, New South Wales 2006, Australia., Bonardi A; Department NEUROFARBA─Pharmaceutical and Nutraceutical Section, University of Firenze, via Ugo Schiff 6, Sesto Fiorentino I-50019, Firenze, Italy., Avgenikos M; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale) D-06120, Germany., Baselious F; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale) D-06120, Germany., Schmidt M; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale) D-06120, Germany., Al-Warhi T; Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia., Abdel-Aziz HA; Applied Organic Chemistry Department, National Research Center, Dokki, Giza 12622, Cairo, Egypt., Rennert R; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale) D-06120, Germany., Peat TS; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia., Supuran CT; Department NEUROFARBA─Pharmaceutical and Nutraceutical Section, University of Firenze, via Ugo Schiff 6, Sesto Fiorentino I-50019, Firenze, Italy., Wessjohann LA; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale) D-06120, Germany., Ibrahim HS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, Egypt.; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale) D-06120, Germany.; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale) D-06120, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Nov 28; Vol. 67 (22), pp. 20438-20454. Date of Electronic Publication: 2024 Nov 17.

Targeting Periplakin of Novel Benzenesulfonamides as Highly Selective Agonists for the Treatment of Vitiligo.

Autor: Zhong H; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Li P; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Yan Q; School of Engineering, China Pharmaceutical University, Nanjing 211198, China., Xia Y; School of Engineering, China Pharmaceutical University, Nanjing 211198, China., Zhang X; School of Engineering, China Pharmaceutical University, Nanjing 211198, China., Lai Y; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Li L; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Wang F; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Shang J; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Zha X; School of Engineering, China Pharmaceutical University, Nanjing 211198, China.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Nov 14; Vol. 67 (21), pp. 19323-19341. Date of Electronic Publication: 2024 Nov 01.