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Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

Publikováno v: Annals of Neurology. 65:304-315

Objective Repair of demyelinated axons in diseases such as multiple sclerosis requires activation of the myelination program in existing or newly recruited oligodendrocyte precursor cells (OPCs). The control of OPC differentiation and initiation of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef0f95d07e69d6d7400f38f6358e713
https://doi.org/10.1002/ana.21581

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LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

Autor: Benxiu Ji, R. Blake Pepinsky, Bryan Sands, Xinhua Lee, Richard L. Cate, Zhaohui Shao, Greg Thill, Norm Allaire, Melissa Levesque, Sha Mi, Thomas Crowell, Steve Perrin, Jane K. Relton, John M. Mccoy

Publikováno v: Nature Neuroscience. 7:221-228

Axon regeneration in the adult CNS is prevented by inhibitors in myelin. These inhibitors seem to modulate RhoA activity by binding to a receptor complex comprising a ligand-binding subunit (the Nogo-66 receptor NgR1) and a signal transducing subunit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8300b0fe1c1dc93c06f9bc7d69d48d53
https://doi.org/10.1038/nn1188

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Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration

Autor: Werner Meier, Ellen Garber, Zhaohui Shao, Lee Walus, R. Blake Pepinsky, Christilyn Graff, Benxiu Ji, Yinghui Hu, Qin Wang, Gym Meng, Sha Mi, Xinhua Lee

Publikováno v: The Journal of pharmacology and experimental therapeutics. 339(2)

LINGO-1 (leucine-rich repeat and Ig domain containing NOGO receptor interacting protein-1) is a negative regulator of myelination and repair of damaged axons in the central nervous system (CNS). Blocking LINGO-1 function leads to robust remyelination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a7f291caf2e129fa80a6b4c20e054a
https://pubmed.ncbi.nlm.nih.gov/21807883

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Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo

Autor: Daniel J. Apicco, Yinghui Hu, Sha Mi, Xinhua Lee, Kevin Guckian, R. Blake Pepinsky, Benxiu Ji, Robert H. Miller

Publikováno v: Molecular and cellular neurosciences. 48(1)

The sphingosine 1-phosphate (S1P) receptor modulators have emerged as a new therapeutic opportunity paradigm for the treatment of immune-mediated demyelinating diseases such as multiple sclerosis (MS). The S1P analog fingolimod (FTY720) has been show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a670d0323626b8c73643d7e7956373
https://pubmed.ncbi.nlm.nih.gov/21740973

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Production of a PEGylated Fab' of the anti-LINGO-1 Li33 antibody and assessment of its biochemical and functional properties in vitro and in a rat model of remyelination

Autor: Benxiu Ji, Xinhua Lee, Ellen Garber, Lee Walus, Sheng Gu, Dingyi Wen, Yaping Sun, R. Blake Pepinsky, Sha Mi, Qin Wang, Zhaohui Shao

Publikováno v: Bioconjugate chemistry. 22(2)

The use of LINGO-1 antagonists to promote repair of damaged myelin is an emerging therapeutic opportunity for treatment of CNS diseases caused by demyelination such as multiple sclerosis. The Li33 anti-LINGO-1 antibody is a potent inducer of myelinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f7e937df83a64045e8fb2a2abbbad6
https://pubmed.ncbi.nlm.nih.gov/21254764

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Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination

Autor: Lee Walus, Yinghui Hu, R. Blake Pepinsky, Guanrong Huang, Zhaohui Shao, Xinhua Lee, Bang Jian Gong, Robert H. Miller, Sha Mi, Benxiu Ji, Weixing Yang, Kenneth J. Rhodes

Publikováno v: Nature medicine. 17(7)

Survival and differentiation of oligodendrocytes are important for the myelination of central nervous system (CNS) axons during development and crucial for myelin repair in CNS demyelinating diseases such as multiple sclerosis. Here we show that deat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3063e6ed7a2341b544445e04c4a7433
https://pubmed.ncbi.nlm.nih.gov/21792216

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Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury

Autor: Benxiu Ji, Xinhua Lee, Martin L. Scott, Lauren Case, Zhaohui Shao, Zhongshu Yang, Jane K. Relton, Joy Wang, Tim Tian, Sha Mi, Zhigang He, Svetlana Shulga-Morskaya, Kai Liu

Publikováno v: Molecular and cellular neurosciences. 39(2)

Oligodendrocyte-myelin glycoprotein (OMgp) is a myelin component that has been shown in vitro to inhibit neurite outgrowth by binding to the Nogo-66 receptor (NgR1)/Lingo-1/Taj (TROY)/p75 receptor complex to activate the RhoA pathway. To investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10883f85554803cc3174365e908358a3
https://pubmed.ncbi.nlm.nih.gov/18692574

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LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury

Autor: Mingwei Li, Xinhua Lee, Kwok-Fai So, R. Blake Pepinsky, Zhaohui Shao, Joy Wang, Wutian Wu, John M. Mccoy, Benxiu Ji, Jane K. Relton, Leung-Wah Yick, Sha Mi

Publikováno v: Molecular and cellular neurosciences. 33(3)

LINGO-1 is a CNS-specific protein and a functional component of the NgR1/p75/LINGO-1 and NgR1/TAJ(TROY)/LINGO-1 signaling complexes that mediate inhibition of axonal outgrowth. These receptor complexes mediate the axonal growth inhibitory effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0f9b1031cca9912f97736e311fdb7c
https://pubmed.ncbi.nlm.nih.gov/17011208

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Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury

Autor: Stephane Budel, R. Blake Pepinsky, Jane K. Relton, Stephen M. Strittmatter, Lee Walus, Thomas Engber, Benxiu Ji, Mingwei Li

Publikováno v: The European journal of neuroscience. 22(3)

Methylprednisolone (MP) is a synthetic glucocorticoid used for the treatment of spinal cord injury (SCI). Soluble Nogo-66 receptor (NgR) ectodomain is a novel experimental therapy for SCI that promotes axonal regeneration by blocking the growth inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c556712a143fd8f328c2a3cbb75e6e03
https://pubmed.ncbi.nlm.nih.gov/16101740

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Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury

Autor: Benxiu Ji, Shuxin Li, Adrienna Jirik, Weiwei Li, Dinah W. Y. Sah, Stephane Budel, Lee Walus, Daniel Lee, Rabacchi Sylvia A, Stephen M. Strittmatter, Jane K. Relton, Mingwei Li, Pepinsky R Blake, Dane S. Worley, Eugene Choi, Betty P. Liu

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(46)

The growth of injured axons in the adult mammalian CNS is limited after injury. Three myelin proteins, Nogo, MAG (myelin-associated glycoprotein), and OMgp (oligodendrocyte myelin glycoprotein), bind to the Nogo-66 receptor (NgR) and inhibit axonal g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f7ed441fa9448d3915d486cfc493f2
https://pubmed.ncbi.nlm.nih.gov/15548666

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