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Akademický článek

Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7.

Autor: Yaoqing Chen, Luyang Cao, Maohua Zhong, Yan Zhang, Chen Han, Qiaoli Li, Jingyi Yang, Dihan Zhou, Wei Shi, Benxia He, Fang Liu, Jie Yu, Ying Sun, Yuan Cao, Yaoming Li, Wenxin Li, Deying Guo, Zhijian Cao, Huimin Yan

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34947 (2012)

For over 30 years, HIV/AIDS has wreaked havoc in the world. In the absence of an effective vaccine for HIV, development of new anti-HIV agents is urgently needed. We previously identified the antiviral activities of the scorpion-venom-peptide-derived

Externí odkaz: https://doaj.org/article/512a5111e47e45cab10a46a5c9612cd3

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Akademický článek

Unpolarized release of vaccinia virus and HIV antigen by colchicine treatment enhances intranasal HIV antigen expression and mucosal humoral responses.

Autor: Yan Zhang, Jingyi Yang, Rong Bao, Yaoqing Chen, Dihan Zhou, Benxia He, Maohua Zhong, Yaoming Li, Fang Liu, Qiaoli Li, Yi Yang, Chen Han, Ying Sun, Yuan Cao, Huimin Yan

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24296 (2011)

The induction of a strong mucosal immune response is essential to building successful HIV vaccines. Highly attenuated recombinant HIV vaccinia virus can be administered mucosally, but even high doses of immunization have been found unable to induce s

Externí odkaz: https://doaj.org/article/14f8ae6cbe724ca69b5741980be6bd4c

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Flagellins of Salmonella Typhi and Nonpathogenic Escherichia coli Are Differentially Recognized through the NLRC4 Pathway in Macrophages

Autor: Benxia He, Fang Liu, Huimin Yan, Yang Xiao, Yaoqing Chen, Jingyi Yang, Dihan Zhou, Ying Sun, Yi Yang, Yuan Cao, Ejuan Zhang, Yaoming Li, Maohua Zhong, Mengji Lu, Yan Zhang

Publikováno v: Journal of Innate Immunity. 6:47-57

Flagellin is recognized by both Toll-like receptor (TLR)5 and NAIP5/NLRC4 inflammasome receptors. We hypothesized that the flagellins derived from different bacteria might differentially activate TLR5 and/or NAIP5/NLRC4 signal pathways. To test this,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91c59eb6a2b52c1363e9b3117b4cb118
https://doi.org/10.1159/000351476

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Antigen replacement of domains D2 and D3 in flagellin promotes mucosal IgA production and attenuates flagellin-induced inflammatory response after intranasal immunization

Autor: Jingyi Yang, Ying Sun, Ejuan Zhang, Yuan Cao, Huimin Yan, Jie Yu, Benxia He, Dihan Zhou, Yi Yang, Maohua Zhong, Yaoqing Chen, Yan Zhang, Yaoming Li

Publikováno v: Human Vaccines & Immunotherapeutics

Targeting early infection in mucosal sites is one of the primary goals for mucosal vaccines so as to prevent pathogen mucosal transmission and infection. The TLR5 agonist flagellin was deemed to be a mucosal adjuvant candidate for clinical usage. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41105b54255c064db1484f88fb17ee79
https://doi.org/10.4161/hv.23809

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Flagellin-PAc Fusion Protein is a High-efficacy Anti-caries Mucosal Vaccine

Autor: Maohua Zhong, Jie Yu, Benxia He, Wei-Qun Shi, Wei Li, Jingyi Yang, Yihua Sun, Yong Yang, Huimin Yan, Yuan Cao, Yang Xiao, Yaoqing Chen, Dihan Zhou, Yan Li, Mingwen Fan, Yongwang Li, Yan Zhang

Publikováno v: Journal of Dental Research. 91:941-947

We previously demonstrated that an anti-caries DNA vaccine intranasally administered with recombinant flagellin protein as a mucosal adjuvant enhanced salivary IgA response and conferred better protection against caries. However, the relatively weak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdfba19ab6f41971008f3b1d5794ada
https://doi.org/10.1177/0022034512457684

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Flagellin Enhances Saliva IgA Response and Protection of Anti-caries DNA Vaccine

Autor: Fei Liu, Jingyi Yang, Dihan Zhou, Wei-Qun Shi, Yaoqing Chen, Charles C. Han, Yong Yang, Yuhong Li, Mingwen Fan, Yan Zhang, Huimin Yan, Benxia He

Publikováno v: Journal of Dental Research. 91:249-254

We and others have shown that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. However, challenges remain because of the low immunogenicity of DNA vaccines. In this study, we used recombinant flagellin prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81c2fa88f1c512b185427f864df9780
https://doi.org/10.1177/0022034511424283

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