Nucleus-cytoplasm cross-talk in the aging brain.

Autor: Benvegnù S; Department of Molecular Neuropathology, Centro de Biología Molecular 'Severo Ochoa', CSIC-UAM, Madrid, Spain.

Publikováno v: Journal of neuroscience research [J Neurosci Res] 2020 Feb; Vol. 98 (2), pp. 247-261. Date of Electronic Publication: 2019 May 26.

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Autor: Willis NJ; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K., Mahy W; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K., Sipthorp J; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K.; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, U.K., Zhao Y; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, U.K., Woodward HL; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K., Atkinson BN; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K., Bayle ED; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K.; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, U.K., Svensson F; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K.; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, U.K., Frew S; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K., Jeganathan F; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K., Monaghan A; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K., Benvegnù S; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K., Jolly S; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K., Vecchia L; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, U.K., Ruza RR; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, U.K., Kjær S; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, U.K., Howell S; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, U.K., Snijders AP; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, U.K., Bictash M; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K., Salinas PC; Department of Cell and Developmental Biology, Laboratory for Molecular and Cellular Biology, University College London, London WC1E 6BT, U.K., Vincent JP; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, U.K., Jones EY; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, U.K., Whiting P; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K., Fish PV; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, U.K.; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 May 26; Vol. 65 (10), pp. 7212-7230. Date of Electronic Publication: 2022 May 10.

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Epigenome‐wide analysis of frailty: Results from two European twin cohorts.

Autor: Mak, Jonathan K. L.^1,2 (AUTHOR) jonathan.mak@ki.se, Skovgaard, Asmus Cosmos³ (AUTHOR), Nygaard, Marianne³ (AUTHOR), Kananen, Laura^1,4 (AUTHOR), Reynolds, Chandra A.^5,6 (AUTHOR), Wang, Yunzhang^1,7 (AUTHOR), Kuja‐Halkola, Ralf¹ (AUTHOR), Karlsson, Ida K.¹ (AUTHOR), Pedersen, Nancy L.¹ (AUTHOR), Hägg, Sara¹ (AUTHOR), Soerensen, Mette^3,8 (AUTHOR), Jylhävä, Juulia^1,4 (AUTHOR)

Publikováno v: Aging Cell. Jun2024, Vol. 23 Issue 6, p1-11. 11p.