Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Benton S. Purnell"'
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106058- (2023)
The epilepsies are a diverse spectrum of disease states characterized by spontaneous seizures and associated comorbidities. Neuron-focused perspectives have yielded an array of widely used anti-seizure medications and are able to explain some, but no
Externí odkaz:
https://doaj.org/article/a9f57acfcf684ef5a89bdeabb0c62cd0
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related death in patients with refractory epilepsy. Convergent lines of evidence suggest that SUDEP occurs due to seizure induced perturbation of respiratory, cardiac, and e
Externí odkaz:
https://doaj.org/article/78a6528bbe044932ae1aa4bb6c2a225c
Autor:
Dong-Suk Kim, Isaac N Pessah, Cristina M Santana, Benton S Purnell, Rui Li, Gordon F Buchanan, Wilson K Rumbeiha
Publikováno v:
Toxicological Sciences. 192:247-264
Acute exposure to high concentrations of hydrogen sulfide (H2S) leads to sudden death and, if survived, lingering neurological disorders. Clinical signs include seizures, loss of consciousness, and dyspnea. The proximate mechanisms underlying H2S-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27800b0f45eef6c29bf7305c667a0d39
https://doi.org/10.1093/toxsci/kfad022
https://doi.org/10.1093/toxsci/kfad022
Publikováno v:
J Physiol
KEY POINTS Sudden unexpected death in epilepsy (SUDEP) is the leading cause of premature death in patients with refractory epilepsy. SUDEP typically occurs during the night, although the reason for this is unclear. We found that, in normally entraine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083ae73cebf1e9bac495df6cd96690c4
https://doi.org/10.1113/jp280856
https://doi.org/10.1113/jp280856
Autor:
Koichi Kaneko, Brandon A. Toth, Kasra Zarei, Uday Singh, Masaaki Iwata, Kalvon T. Steffen, Gordon F. Buchanan, Huxing Cui, Gen Shinozaki, Benton S. Purnell, Hyunkeun Ryan Cho, Rui Li, Shelley Lee, Michael E. Dailey, Johnny R. Malicoat, Kenji Saito, Annice Najafi, Takehiko Yamanashi
Publikováno v:
Journal of Psychiatric Research. 133:205-211
Most of the animal studies using inflammation-induced cognitive change have relied on behavioral testing without objective and biologically solid methods to quantify the severity of cognitive disturbances. We have developed a bispectral EEG (BSEEG) m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718519713012c3b7de422d81fcc06da5
https://doi.org/10.1016/j.jpsychires.2020.12.036
https://doi.org/10.1016/j.jpsychires.2020.12.036
Publikováno v:
Brain communications. 4(5)
Sudden unexpected death in epilepsy is the leading cause of epilepsy related death. Currently, there are no reliable methods for preventing sudden unexpected death in epilepsy. The precise pathophysiology of sudden unexpected death in epilepsy is unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21dbd2781b26c25b8f779007a74a62e0
https://pubmed.ncbi.nlm.nih.gov/36196086
https://pubmed.ncbi.nlm.nih.gov/36196086
Autor:
Benton S. Purnell, Sydney Thompson, Tenise Bowman, Jayant Bhasin, Steven George, Brian Rust, Madhuvika Murugan, Denise Fedele, Detlev Boison
Publikováno v:
Neuropharmacology. 222:109296
Alcohol-related poisoning is the foremost cause of death resulting from excessive acute alcohol consumption. Respiratory failure is crucial to the pathophysiology of fatal alcohol poisoning. Alcohol increases accumulation of extracellular adenosine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e77f1b7dc47126d4bd66bb7180e868
https://doi.org/10.1016/j.neuropharm.2022.109296
https://doi.org/10.1016/j.neuropharm.2022.109296
Autor:
Denise Fedele, Vineet C. Chitravanshi, Madhuvika Murugan, Detlev Boison, Trong Huynh, Benton S. Purnell, Omar Ashraf
Publikováno v:
Neuropharmacology
Sudden unexpected death in epilepsy (SUDEP) is a leading cause of death in patients with refractory epilepsy. Centrally-mediated respiratory dysfunction has been identified as one of the principal mechanisms responsible for SUDEP. Seizures generate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f75eb7b3d514b44446edf4838ca1c88
https://pubmed.ncbi.nlm.nih.gov/33212114
https://pubmed.ncbi.nlm.nih.gov/33212114
Autor:
Benton S. Purnell, Gordon F. Buchanan
Publikováno v:
J Appl Physiol (1985)
It is widely agreed that breathing is subject to circadian regulation. Circadian differences in respiratory physiology significantly impact a number of diseases including sleep apnea, asthma, and seizure-induced death. The effect of time of day on br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71786aa1ba8ab7e1285724ac3e8c4d6
https://europepmc.org/articles/PMC7469233/
https://europepmc.org/articles/PMC7469233/
Autor:
Benton S. Purnell, Stephanie L. Alberico, Nicole Leibold, Cornelius Gross, Haleigh R. Smith, Callie M. Ginapp, Enrica Audero, Gordon F. Buchanan, Daniel A. Rappoport, Nicole M. Bode, Youngcho Kim
Publikováno v:
Journal of Neuroscience, 38(8), 1915-1925. Society for Neuroscience
Arousal from sleep in response to CO2is a critical protective phenomenon. Dysregulation of CO2-induced arousal contributes to morbidity and mortality from prevalent diseases, such as obstructive sleep apnea and sudden infant death syndrome. Despite t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90377fd8b92d754852445328ed4cb976
https://doi.org/10.1523/jneurosci.2182-17.2018
https://doi.org/10.1523/jneurosci.2182-17.2018