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Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.

Autor: Rasooly D; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA. drasooly@bwh.harvard.edu.; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA. drasooly@bwh.harvard.edu., Peloso GM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave Crosstown Centre, Boston, MA, 02118, USA., Pereira AC; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, Av Dr Eneas de Carvalho Aguiar 54, São Paulo, 5403000, Brazil.; Genetics Department, Harvard Medical School, Harvard University, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA., Dashti H; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA.; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA, 02142, USA., Giambartolomei C; Health Data Science Centre, Human Technopole, V.le Rita Levi-Montalcini, 1, Milan, 20157, Italy.; Central RNA Lab, Non-coding RNAs and RNA-based Therapeutics, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy., Wheeler E; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Addenbrookes Hospital, IMS, Box 285, Cambridge, CB2 0QQ, UK., Aung N; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, UK., Ferolito BR; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA., Pietzner M; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Addenbrookes Hospital, IMS, Box 285, Cambridge, CB2 0QQ, UK.; Computational Medicine, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Kapelle Ufer 2, Berlin, 10117, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Farber-Eger EH; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA., Wells QS; Vanderbilt University Med. Ctr., Departments of Medicine (Cardiology), Biomedical Informatics, and Pharmacology, Nashville, TN, USA., Kosik NM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA., Gaziano L; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK., Posner DC; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA., Bento AP; Department of Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK., Hui Q; Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30322, USA.; Atlanta VA Health Care System, 1670 Clairmont Road, Decatur, GA, 30033, USA., Liu C; Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30322, USA., Aragam K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA, 02142, USA.; Massachusetts General Hospital, Boston, MA, 02114, USA., Wang Z; Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30322, USA., Charest B; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA., Huffman JE; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA., Wilson PWF; Atlanta VA Health Care System, 1670 Clairmont Road, Decatur, GA, 30033, USA.; Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1639 Pierce Dr NE, Atlanta, GA, 30322, USA., Phillips LS; Atlanta VA Health Care System, 1670 Clairmont Road, Decatur, GA, 30033, USA.; Division of Endocrinology, Emory University, 101 Woodruff Circle, WMRB 1027, Atlanta, GA, 30322, USA., Whittaker J; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, United Kingdom., Munroe PB; William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; National Institute for Health Research, Barts Biomedical Research Centre, Queen Mary University of London, London, UK., Petersen SE; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, UK.; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, EC1M 68Q, UK., Cho K; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA.; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA., Leach AR; Department of Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK., Magariños MP; Department of Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK., Gaziano JM; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA.; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Addenbrookes Hospital, IMS, Box 285, Cambridge, CB2 0QQ, UK.; Computational Medicine, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Kapelle Ufer 2, Berlin, 10117, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30322, USA.; Atlanta VA Health Care System, 1670 Clairmont Road, Decatur, GA, 30033, USA.; Department of Biomedical Informatics, Emory University School of Medicine, 1639 Pierce Dr NE, Atlanta, GA, 30332, USA., Joseph J; Cardiology Section, VA Providence Healthcare System, 830 Chalkstone Avenue, Providence, RI, 02908, USA. jacob.joseph@va.gov.; Department of Medicine, Warren Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI, 02903, USA. jacob.joseph@va.gov., Casas JP; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA.; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.

Publikováno v: Nature communications [Nat Commun] 2023 Jul 10; Vol. 14 (1), pp. 3826. Date of Electronic Publication: 2023 Jul 10.

COVID-19 and the elaboration of personal plans in + 50: a Brazilian experience.

Autor: Garcia KR; Postgraduate Programme in Health Sciences and Technologies (PGCTS), University of Brasilia, Faculty of Ceilândia (FCE) Campus Universitário - Centro Metropolitano, Ceilândia Sul, CEP:, 72220-275, Brasília - DF, Brasil. kerolynramos@gmail.com.; University of Envelhecer (UniSER) of University of Brasilia, Brasilia, Brazil. kerolynramos@gmail.com., Bento AP; Postgraduate Programme in Health Sciences and Technologies (PGCTS), University of Brasilia, Faculty of Ceilândia (FCE) Campus Universitário - Centro Metropolitano, Ceilândia Sul, CEP:, 72220-275, Brasília - DF, Brasil.; University of Envelhecer (UniSER) of University of Brasilia, Brasilia, Brazil., de Oliveira AG; University of Envelhecer (UniSER) of University of Brasilia, Brasilia, Brazil., da Silva RA; University of Envelhecer (UniSER) of University of Brasilia, Brasilia, Brazil., Chiarello MD; University of Envelhecer (UniSER) of University of Brasilia, Brasilia, Brazil.; Support Centre for Technological Development (CDT) of University of Brasilia, Brasilia, Brazil., Chariglione IPFS; Post-Graduate Program in Developmental and School Psychology, University of Brasilia, Brasilia, Brazil., Karnikowski MGO; Postgraduate Programme in Health Sciences and Technologies (PGCTS), University of Brasilia, Faculty of Ceilândia (FCE) Campus Universitário - Centro Metropolitano, Ceilândia Sul, CEP:, 72220-275, Brasília - DF, Brasil.; University of Envelhecer (UniSER) of University of Brasilia, Brasilia, Brazil.

Publikováno v: BMC public health [BMC Public Health] 2023 Feb 01; Vol. 23 (1), pp. 221. Date of Electronic Publication: 2023 Feb 01.

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.

Autor: Gaziano L; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Giambartolomei C; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Pereira AC; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.; Genetics Department, Harvard Medical School, Harvard University, Boston, MA, USA., Gaulton A; Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Posner DC; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Swanson SA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ho YL; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Iyengar SK; Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University and Louis Stoke, Cleveland VA, Cleveland, OH, USA., Kosik NM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Vujkovic M; The Corporal Michael J. Crescenz VA Medical Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Gagnon DR; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Biostatistics, School of Public Health, Boston University, Boston, MA, USA., Bento AP; Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Barrio-Hernandez I; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Rönnblom L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Hagberg N; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Lundtoft C; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Langenberg C; Berlin Institute of Health, Charité University Medicine Berlin, Berlin, Germany.; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Pietzner M; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Valentine D; Institute of Health Informatics, University College London, London, UK.; Health Data Research, University College London, London, UK., Gustincich S; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy., Tartaglia GG; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy., Allara E; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Surendran P; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Burgess S; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Zhao JH; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Peters JE; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College, London, UK., Prins BP; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK., Angelantonio ED; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Devineni P; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Shi Y; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Lynch KE; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Department of Internal Medicine, Epidemiology, University of Utah, Salt Lake City, UT, USA., DuVall SL; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Department of Internal Medicine, Epidemiology, University of Utah, Salt Lake City, UT, USA., Garcon H; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Thomann LO; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Zhou JJ; Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA.; Phoenix VA Health Care System, Phoenix, AZ, USA., Gorman BR; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Huffman JE; Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., O'Donnell CJ; Cardiology, VA Boston Healthcare System, Boston, MA, USA.; Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Tsao PS; Epidemiology Research and Information Center (ERIC), VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA., Beckham JC; MIRECC, Durham VA Medical Center, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA., Pyarajan S; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Muralidhar S; Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA., Huang GD; Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA., Ramoni R; Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA., Beltrao P; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Danesh J; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Hung AM; VA Tennessee Valley Healthcare System, Nashville, TN, USA.; Nephrology & Hypertension, Vanderbilt University, Nashville, TN, USA., Chang KM; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Sun YV; Atlanta VA Health Care System, Decatur, GA, USA.; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA., Joseph J; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Medicine, Cardiovascular, VA Boston Healthcare System and Brigham & Women's Hospital, Boston, MA, USA., Leach AR; Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Edwards TL; Department of Veterans Affairs, Tennessee Valley Healthcare System, Vanderbilt University, Nashville, TN, USA.; Medicine, Epidemiology, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Gaziano JM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Butterworth AS; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK. asb38@medschl.cam.ac.uk., Casas JP; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA. jpcasasromero@bwh.harvard.edu.; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jpcasasromero@bwh.harvard.edu.

Publikováno v: Nature medicine [Nat Med] 2021 Apr; Vol. 27 (4), pp. 668-676. Date of Electronic Publication: 2021 Apr 09.