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Vtc5 Is Localized to the Vacuole Membrane by the Conserved AP-3 Complex to Regulate Polyphosphate Synthesis in Budding Yeast

Autor: Amanda Bentley-DeSousa, Michael Downey

Publikováno v: mBio, Vol 12, Iss 5 (2021)

Long polymers of inorganic phosphates called polyphosphates are ubiquitous across biological kingdoms. From bacteria to humans, they have diverse functions related to protein homeostasis, energy metabolism, and cell signaling.

Externí odkaz: https://doaj.org/article/d96b9f6c7b5f43e89cc2ba12583efb3f

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C.

Autor: Wang X, Xu P, Bentley-DeSousa A, Hancock-Cerutti W, Cai S, Johnson BT, Tonelli F, Talaia G, Alessi DR, Ferguson SM, De Camilli P

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 08. Date of Electronic Publication: 2024 Jun 08.

Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition.

Autor: Talaia G; Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Wu Tsai Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Bentley-DeSousa A; Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Wu Tsai Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Ferguson SM; Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Wu Tsai Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 17. Date of Electronic Publication: 2023 Dec 17.

Proteins required for vacuolar function are targets of lysine polyphosphorylation in yeast

Autor: Alix Denoncourt, Yi-Chieh Tseng, Liam McCarthy, Michael Downey, Matthew Gabriel, Amanda Bentley-DeSousa

Publikováno v: FEBS Letters. 594:21-30

Polyphosphates (polyP) are long chains of inorganic phosphates that can be attached to lysine residues of target proteins as a non-enzymatic post-translational modification. This modification, termed polyphosphorylation, may be particularly prevalent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2bd5c9bb0a27edc1dd60070ec84034
https://doi.org/10.1002/1873-3468.13588