A BRISC-SHMT Complex Deubiquitinates IFNAR1 and Regulates Interferon Responses

Autor: Hui Zheng, Vibhor Gupta, Jeffrey Patterson-Fortin, Sabyasachi Bhattacharya, Kanstantsin Katlinski, Junmin Wu, Bentley Varghese, Christopher J. Carbone, Bernadette Aressy, Serge Y. Fuchs, Roger A. Greenberg

Publikováno v: Cell Reports, Vol 5, Iss 1, Pp 180-193 (2013)

Lysine63-linked ubiquitin (K63-Ub) chains represent a particular ubiquitin topology that mediates proteasome-independent signaling events. The deubiquitinating enzyme (DUB) BRCC36 segregates into distinct nuclear and cytoplasmic complexes that are sp

Externí odkaz: https://doaj.org/article/14bca6ce80054c20bd1f9fedc711dd5e

Data from Impaired Turnover of Prolactin Receptor Contributes to Transformation of Human Breast Cells

Autor: Serge Y. Fuchs, Hallgeir Rui, Chengbao Liu, Thai H. Tran, Bentley Varghese, Alexandr Plotnikov

Signaling by polypeptide hormone prolactin (PRL) is mediated by its cognate receptor (PRLr). PRLr is commonly stabilized in human breast cancer due to decreased phosphorylation of residue Ser349, which when phosphorylated recruits the βTrcp E3 ubiqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e319455332f1795c1750ec0a8a443c2
https://doi.org/10.1158/0008-5472.c.6499520.v1

Prolactin stimulates ubiquitination, initial internalization, and degradation of its receptor via catalytic activation of Janus kinase 2

Autor: Christopher J. Carbone, Stuart J. Frank, Alexander Plotnikov, Charles V. Clevenger, K.G. Suresh Kumar, Vincent Goffin, Elizabeth M. Jablonski, Serge Y. Fuchs, Bentley Varghese, Luqin Deng, Chellappagounder Thangavel, Gayathri Swaminathan

Publikováno v: Journal of Endocrinology. 196:R1-R7

Prolactin (PRL) activates its receptor to initiate signal transduction pathways (including activation of Janus kinases, Jak) but also stimulates downregulation of this receptor to limit the magnitude and duration of signaling. Degradation of the long

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24711ab050811f90bebac081e55eabf
https://doi.org/10.1677/joe-07-0554

Ligand-Stimulated Downregulation of the Alpha Interferon Receptor: Role of Protein Kinase D2▿ §

Autor: Darren P. Baker, Serge Y. Fuchs, Juan Qian, Bentley Varghese, Hui Zheng

Alpha interferon (IFN-α) controls homeostasis of hematopoietic stem cells, regulates antiviral resistance, inhibits angiogenesis, and suppresses tumor growth. This cytokine is often used to treat cancers and chronic viral infections. The extent of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245ca131e97919cba039b52bf8c05d50
https://europepmc.org/articles/PMC3028644/

Basal Ubiquitin-independent Internalization of Interferon α Receptor Is Prevented by Tyk2-mediated Masking of a Linear Endocytic Motif*

Autor: K.G. Suresh Kumar, Bentley Varghese, Stefan N. Constantinescu, Serge Y. Fuchs, Sandra Pellegrini, Darren P. Baker, Anamika Banerjee

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 283 (27), pp.18566-72. ⟨10.1074/jbc.M800991200⟩
Journal of Biological Chemistry, 2008, 283 (27), pp.18566-72. ⟨10.1074/jbc.M800991200⟩

International audience; Linear endocytic motifs of signaling receptors as well as their ubiquitination determine the rate of ligand-induced endocytosis that mediates down-regulation of these receptors and restricts the magnitude and duration of their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3794a7f107868f74c531c1231d0ad47e
https://europepmc.org/articles/PMC2441555/