A genomic infection control study for Staphylococcus aureus in two Ghanaian hospitals

Autor: Donkor ES, Jamrozy D, Mills RO, Dankwah T, Amoo PK, Egyir B, Badoe EV, Twasam J, Bentley SD

Publikováno v: Infection and Drug Resistance, Vol Volume 11, Pp 1757-1765 (2018)

Eric S Donkor,1 Dorota Jamrozy,2 Richael O Mills,3,4 Thomas Dankwah,3 Philip K Amoo,5 Beverly Egyir,6 Ebenezer V Badoe,7 Joana Twasam,8 Stephen D Bentley2 1Department of Medical Microbiology, School of Biomedical and Allied Health Sciences, College o

Externí odkaz: https://doaj.org/article/3b5b54ed526d45198dfc8c3957ab2802

Excision-reintegration at a pneumococcal phase-variable restriction-modification locus drives within- and between-strain epigenetic differentiation and inhibits gene acquisition

Autor: Kwun MJ, Oggioni MR, De Ste Croix M, Bentley SD, Croucher NJ

Phase-variation of Type I restriction-modification systems can rapidly alter the sequence motifs they target, diversifying both the epigenetic patterns and endonuclease activity within clonally descended populations. Here, we characterize the Strepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4094::800ab6970053d4a61931122bafe09378
http://hdl.handle.net/11585/798239

On the evolutionary ecology of multidrug resistance in bacteria

Autor: Lehtinen, S, Blanquart, F, Lipsitch, M, Fraser, C, Bentley, SD, Croucher, NJ, Lees, JA, Turner, P

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2019, 15 (5), pp.e1007763. ⟨10.1371/journal.ppat.1007763⟩
PLoS Pathogens, Vol 15, Iss 5, p e1007763 (2019)

Resistance against different antibiotics appears on the same bacterial strains more often than expected by chance, leading to high frequencies of multidrug resistance. There are multiple explanations for this observation, but these tend to be specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7954d9e6b3777007da63077bd3a34fe7
https://hal.archives-ouvertes.fr/hal-02347472

Defining the estimated core genome of bacterial populations using a Bayesian decision model

Autor: Van Tonder, AJ, Mistry, S, Bray, JE, Hill, DMC, Cody, AJ, Farmer, CL, Klugman, KP, Von Gottberg, A, Bentley, SD, Parkhill, J, Jolley, KA, Maiden, MCJ, Brueggemann, AB

Publikováno v: PLoS Computational Biology, Vol 10, Iss 8, p e1003788 (2014)
PLoS Computational Biology

The bacterial core genome is of intense interest and the volume of whole genome sequence data in the public domain available to investigate it has increased dramatically. The aim of our study was to develop a model to estimate the bacterial core geno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dad9e65f9e9335899be57676c8502bb8
https://doi.org/10.1371/journal.pcbi.1003788

Evidence of antimicrobial resistance-conferring genetic elements among pneumococci isolated prior to 1974

Autor: Wyres, KL, van Tonder, A, Lambertsen, LM, Hakenbeck, R, Parkhill, J, Bentley, SD, Brueggemann, AB

BACKGROUND: Antimicrobial resistance among pneumococci has greatly increased over the past two to three decades. Resistance to tetracycline (tet(M)), chloramphenicol (cat) and macrolides (erm(B) and/or mef(A/E)) is generally conferred by acquisition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d378bb587591ab8068d6d2cccc4ad326
https://doi.org/10.1186/1471-2164-14-500